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Protein

Cytochrome c oxidase subunit 1

Gene

cox1

Organism
Pinus strobus (Eastern white pine)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transport, Respiratory chainUniRule annotation, Transport
LigandCopperUniRule annotationSAAS annotation, HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:cox1Imported
Encoded oniMitochondrionImported
OrganismiPinus strobus (Eastern white pine)Imported
Taxonomic identifieri3348 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaPinidaePinalesPinaceaePinusStrobus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 38HelicalSequence analysisAdd BLAST19
Transmembranei185 – 208HelicalSequence analysisAdd BLAST24
Transmembranei245 – 261HelicalSequence analysisAdd BLAST17
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Transmembranei308 – 327HelicalSequence analysisAdd BLAST20
Transmembranei339 – 360HelicalSequence analysisAdd BLAST22
Transmembranei380 – 396HelicalSequence analysisAdd BLAST17
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Transmembranei457 – 481HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 519COX1InterPro annotationAdd BLAST519

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

CDDicd01663 Cyt_c_Oxidase_I, 1 hit
Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR033944 Cyt_c_oxase_su1_dom
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0N7AKF1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNLVRWPFP TNHKDIGTPH SIFGAIAGVM GTCFSVPIRM ELAQPGDQIL
60 70 80 90 100
GGNHQPHNVS ITAHASPMIP FMVMPAVIGG SGNWSVPIPI XXXXAFPRLN
110 120 130 140 150
NIPSRLLPPS LLLPLSPASV EVGSGTGWTV YPPLSGITSH SGGAADPAIS
160 170 180 190 200
SPHLTGVSSI SGAINFITTI PNMRGPGMTM HRSPLFVRSV PVTAFLLLSS
210 220 230 240 250
LPVPAGAITM LSTDRSFNTT FFDPAGGGDP ILYQHLFRFS GHPEVYIPIL
260 270 280 290 300
PGFGIISHIV STFSGKPVFG YPGMVYAMIS IGVPGFLVRA HHMFTVGSDV
310 320 330 340 350
DTRAHSTAAT MIIAVPTGIK ISSRIATMWG GSIRYKTPML SAAGSIFPST
360 370 380 390 400
IGGLTGIVLA NPGLDIALHD THYVVAHSHY VLSMGAVSAS SAGFHFRVGK
410 420 430 440 450
IPGRTYPETL GQIHLRITLF GVNSTFFPMH FLGLSGMPRR IPDYPDAYAG
460 470 480 490 500
WNALSSFGPY VSVVGIFRFF VVVTITLGGG YNKRCAPSPR AVEHNPTTPE
510 520
WMVQSPPALH TPEELPAIKE TL
Length:522
Mass (Da):55,466
Last modified:January 20, 2016 - v1
Checksum:i6A7C9A643F85972A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KM672417 Genomic DNA Translation: AJP33532.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KM672417 Genomic DNA Translation: AJP33532.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00705

Family and domain databases

CDDicd01663 Cyt_c_Oxidase_I, 1 hit
Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR033944 Cyt_c_oxase_su1_dom
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0N7AKF1_PINST
AccessioniPrimary (citable) accession number: A0A0N7AKF1
Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: January 20, 2016
Last modified: November 7, 2018
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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