Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

5-demethoxyubiquinone hydroxylase, mitochondrial

Gene
N/A
Organism
Strongyloides papillosus (Intestinal threadworm)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.UniRule annotation

Cofactori

Fe cationUniRule annotationNote: Binds 2 iron ions per subunit.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron 1UniRule annotation1
Metal bindingi89Iron 1UniRule annotation1
Metal bindingi89Iron 2UniRule annotation1
Metal bindingi92Iron 1UniRule annotation1
Metal bindingi141Iron 2UniRule annotation1
Metal bindingi177Iron 1UniRule annotation1
Metal bindingi177Iron 2UniRule annotation1
Metal bindingi180Iron 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenaseUniRule annotation, Oxidoreductase
Biological processUbiquinone biosynthesisUniRule annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
5-demethoxyubiquinone hydroxylase, mitochondrialUniRule annotation (EC:1.14.13.-UniRule annotation)
Short name:
DMQ hydroxylaseUniRule annotation
Alternative name(s):
Ubiquinone biosynthesis monooxygenase COQ7UniRule annotation
OrganismiStrongyloides papillosus (Intestinal threadworm)Imported
Taxonomic identifieri174720 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaTylenchidaPanagrolaimomorphaStrongyloidoideaStrongyloididaeStrongyloides
Proteomesi
  • UP000046392 Componenti: Genome Assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the COQ7 family.UniRule annotation

Family and domain databases

CDDicd01042 DMQH, 1 hit
HAMAPiMF_01658 COQ7, 1 hit
InterProiView protein in InterPro
IPR009078 Ferritin-like_SF
IPR011566 Ubq_synth_Coq7
PANTHERiPTHR11237 PTHR11237, 1 hit
PfamiView protein in Pfam
PF03232 COQ7, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0N5BXS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLLKHTFIK NQFVSNITIR MLSADSSMPK KTAFERTPLS DEERKKLIQK
60 70 80 90 100
ILRVDHMGEL AADRIYAGQL SILKGSSVSS VIQHMWKDEK HHLDTFERLI
110 120 130 140 150
EKKNMNSTVL APILSAVAFG LGAGTAMISK EAAMACTIAV EELIVKHYND
160 170 180 190 200
QIKELVADDP VVHADLLKTI SKFRDEELEH HDTGIKFDGL TTPGYNILKG
210
IIQNGCKAAI WVSEKI
Length:216
Mass (Da):24,177
Last modified:December 9, 2015 - v1
Checksum:iE49C0541275EC218
GO

Genome annotation databases

WBParaSiteiSPAL_0001059100.1; SPAL_0001059100.1; SPAL_0001059100

Similar proteinsi

Entry informationi

Entry nameiA0A0N5BXS1_STREA
AccessioniPrimary (citable) accession number: A0A0N5BXS1
Entry historyiIntegrated into UniProtKB/TrEMBL: December 9, 2015
Last sequence update: December 9, 2015
Last modified: March 28, 2018
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health