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UniProtKB - A0A0N4SW93 (A0A0N4SW93_MOUSE)

Entry version 39 (19 Jan 2022)
Sequence version 1 (09 Dec 2015)
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Protein
Submitted name:

C2 domain-containing protein 5

Gene

C2cd5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
C2 domain-containing protein 5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C2cd5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1921991, C2cd5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000030279

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		A0A0N4SW93

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A0A0N4SW93

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		359883

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000030279, Expressed in embryo and 262 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A0A0N4SW93, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A0A0N4SW93

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 109C2InterPro annotationAdd BLAST109

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni638 – 670DisorderedSequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi655 – 670Basic and acidic residuesSequence analysisAdd BLAST16

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000212

Identification of Orthologs from Complete Genome Data

More...OMAi		NHLVAPE

Database of Orthologous Groups

More...OrthoDBi		266134at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd08688, C2_KIAA0528-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037785, C2_C2CD5
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR038983, C2CD5

The PANTHER Classification System

More...PANTHERi		PTHR37412, PTHR37412, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00168, C2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00239, C2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49562, SSF49562, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

A0A0N4SW93-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGKLKVKIV AGRHLPVMDR ASDLTDAFVE VKFGNTTFKT DVYLKSLNPQ 
        60         70         80         90        100
WNSEWFKFEV DDEDLQDEPL QITVLDHDTY SANDAIGKVY IDIDPLLYSE 
       110        120        130        140        150
AATVISGWFP IYDTIHGIRG EINVVVKVDL FNDSNRFRQS SCGVKFFCTT 
       160        170        180        190        200
SIPKCYRAVV IHGFVEELVV NEDPEYQWID RIRTPRASNE ARQRLISLMS 
       210        220        230        240        250
GELQRKIGLK VLEMRGNAVV GYLQCFDLEG ESGLVVRAIG TACTLDKLSS 
       260        270        280        290        300
PAAFLPACSS PSRELKESPL VHPPSHGCRS THNSPIHTAT GSRLTQNFSV 
       310        320        330        340        350
SVPTLIYTGM GSGSAGKEGG PFKALLRQQT QSALEQRGGS PHRFCRRREF 
       360        370        380        390        400
PFLTLTAFPP GLLVHVGGVV SARSVKLLDR IHNPDEPETR DAWWAEIRQE 
       410        420        430        440        450
IKSHAKALGC HAVVGYSEST SICEEVCILS ASGTAAVLNP RFLQEGTVEG 
       460        470        480        490        500
CLEQRIEENL PVGCGFCHIP YDELNMPFPA HLTYCYNCRK QKVPDVLFTT 
       510        520        530        540        550
IDLPTDAVVV GKGCLIQARL CRLKKKAQAE ANATAISNLL PFMEYEVHTQ 
       560        570        580        590        600
LMNKLKLKGM NALFGLRIQI TVGETMLMGL ASATGVYLAA LPTPGGIQIA 
       610        620        630        640        650
GKTPNDGSYE QHISHMQKRI NDTIAKNKEL YEITPPEVSE EMIGSPIPEP 
       660        670        680        690        700
RQRSRLLRSQ SESSDEVTEL DLSHGKKDAF VLEIDDTDAM EDVHSLLTDA 
       710        720        730        740        750
PPPSGFYSCN TEIMPGINNW TSEIQMFTSV RVVRLSSLNL TNQALNKNFN 
       760        770        780        790        800
GLCENLLKSL YFKLRSMTPC CLCHVNFTVS LPEDELIQVT VTAVAITFDK 
       810        820        830        840        850
NQALQTTKPH VEKSLQRAST DNEELLQFPL ELCSDSLPPH PFPAAKEHLE 
       860        870        880        890        900
SANSNSGIPA AQRATSVDYS SFADRCSSWI ELIRLKAQTI RRGSIKTTVT 
       910        920        930        940        950
VEKASAMGDG NFRNRSAPPC ASPTVGVVKM TPLSFIPGAK ITKYLGIINM 
       960        970        980        990       1000
FFIRETTSLR EEGGVSGFLH AFIAEVFAMV RAHVAALGGN AVVSYIMKQC 
      1010       1020       1030       1040       1050
VFMENPSKNQ AQCLINVSGD AVVFVRDSDL EVMSSQQPAA NCQPSCTGEV 

TT
Length:1,052
Mass (Da):115,814
Last modified:December 9, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F7CB7BBB0800941
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7TPS5C2CD5_MOUSE
C2 domain-containing protein 5
C2cd5 Cdp138, Kiaa0528
1,016Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q026E9Q026_MOUSE
C2 domain-containing protein 5
C2cd5 5730419I09Rik
999Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SVN0A0A0N4SVN0_MOUSE
C2 domain-containing protein 5
C2cd5
232Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SW69A0A0N4SW69_MOUSE
C2 domain-containing protein 5
C2cd5
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SW58A0A0N4SW58_MOUSE
C2 domain-containing protein 5
C2cd5
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_017177289.1, XM_017321800.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000203673; ENSMUSP00000145425; ENSMUSG00000030279

Database of genes from NCBI RefSeq genomes

More...GeneIDi		74741

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_017177289.1, XM_017321800.1

3D structure databases

SMRiA0A0N4SW93
ModBaseiSearch...

Proteomic databases

EPDiA0A0N4SW93
jPOSTiA0A0N4SW93
ProteomicsDBi359883

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24138, 50 antibodies from 19 providers

The DNASU plasmid repository

More...DNASUi		74741

Genome annotation databases

EnsembliENSMUST00000203673; ENSMUSP00000145425; ENSMUSG00000030279
GeneIDi74741

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9847
MGIiMGI:1921991, C2cd5
VEuPathDBiHostDB:ENSMUSG00000030279

Phylogenomic databases

GeneTreeiENSGT00390000000212
OMAiNHLVAPE
OrthoDBi266134at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		74741, 5 hits in 64 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		C2cd5, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000030279, Expressed in embryo and 262 other tissues
ExpressionAtlasiA0A0N4SW93, baseline and differential

Family and domain databases

CDDicd08688, C2_KIAA0528-like, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR037785, C2_C2CD5
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR038983, C2CD5
PANTHERiPTHR37412, PTHR37412, 1 hit
PfamiView protein in Pfam
PF00168, C2, 1 hit
SMARTiView protein in SMART
SM00239, C2, 1 hit
SUPFAMiSSF49562, SSF49562, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0N4SW93_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0N4SW93
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 9, 2015
Last sequence update: December 9, 2015
Last modified: January 19, 2022
This is version 39 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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