UniProtKB - A0A0N4SV35 (A0A0N4SV35_MOUSE)
Protein
Submitted name:
E3 ubiquitin-protein ligase MARCHF8
Gene
Marchf8
Organism
Mus musculus (Mouse)
Status
Names & Taxonomyi
Protein namesi | Submitted name: E3 ubiquitin-protein ligase MARCHF8Imported |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1919029, Marchf8 |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 433 – 455 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 475 – 495 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSMUSG00000025702, Expressed in blood and 261 other tissues |
ExpressionAtlasi | A0A0N4SV35, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 350 – 411 | RING-CH-typeInterPro annotationAdd BLAST | 62 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 23 – 64 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 542 – 561 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 37 – 64 | PolarSequence analysisAdd BLAST | 28 | |
Compositional biasi | 544 – 560 | PolarSequence analysisAdd BLAST | 17 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000158282 |
OrthoDBi | 1222747at2759 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR011016, Znf_RING-CH IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF12906, RINGv, 1 hit |
SMARTi | View protein in SMART SM00744, RINGv, 1 hit |
PROSITEi | View protein in PROSITE PS51292, ZF_RING_CH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
A0A0N4SV35-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSMPLHQISA IPSQDAISAR VYRSKTKDKE QNEKTLGHSM SHPSNISKAG
60 70 80 90 100
SSPPSTTAPV SAFSRTSVTP SNQDICSSSA VFSECCHFSP VQSAVVLKAP
110 120 130 140 150
PCQSSLTQGL TVTVLCKDTL QASKKNPFGS DWDQVLTPAK NTKTRRALRF
160 170 180 190 200
SKSLSDVGEK TQESLESFDY MERTCSEGKL VLPQGSSLKK NRLRHKEKRA
210 220 230 240 250
EHCPPLSHSK HSPILSLSTN HSAVSKREAG KGSVRIPLLE EKADGEARLR
260 270 280 290 300
SQRLLRYLFS LSRGSSASSL HRFHELESHA SHLHTAKSSS WLAGSMDFCS
310 320 330 340 350
DEMGDDDVFE DTSSAKLKNR VLRAPLCSVE KDSDLDCPSL LSEKCTPISP
360 370 380 390 400
VSTSGDACRI CHCEGDDESP LITPCHCTGS LHFVHQACLQ QWIKSSDTRC
410 420 430 440 450
CELCKYEFIM ETKLKPLRKW EKLQMTASER RKIMCSVTFH VIAITCVVWS
460 470 480 490 500
LYVLIDRTAE EIKQGQVTGI LEWPFWTKLV VVAIGFTGGL LFMYVQCKVY
510 520 530 540 550
LQLWKRLKAY NRVIYVQNCP ETSKKNIFEK SALTEPTLEN KEGHGMCHST
560
TNSSCTEPED TGAEIINV
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9DBD2 | MARH8_MOUSE | E3 ubiquitin-protein ligase MARCHF8 | Marchf8 March8, Mir | 286 | Annotation score: | ||
A0A0N4SVK0 | A0A0N4SVK0_MOUSE | E3 ubiquitin-protein ligase MARCHF8 | Marchf8 March8 | 247 | Annotation score: | ||
A0A0N4SW32 | A0A0N4SW32_MOUSE | E3 ubiquitin-protein ligase MARCHF8 | Marchf8 March8 | 176 | Annotation score: | ||
F6THH9 | F6THH9_MOUSE | E3 ubiquitin-protein ligase MARCHF8 | Marchf8 March8 | 232 | Annotation score: | ||
A0A0N4SVT6 | A0A0N4SVT6_MOUSE | E3 ubiquitin-protein ligase MARCHF8 | Marchf8 March8 | 45 | Annotation score: | ||
A0A0N4SVD9 | A0A0N4SVD9_MOUSE | E3 ubiquitin-protein ligase MARCHF8 | Marchf8 March8 | 79 | Annotation score: | ||
A0A0N4SVD4 | A0A0N4SVD4_MOUSE | E3 ubiquitin-protein ligase MARCHF8 | Marchf8 March8 | 31 | Annotation score: | ||
A0A0N4SVW5 | A0A0N4SVW5_MOUSE | E3 ubiquitin-protein ligase MARCHF8 | Marchf8 March8 | 10 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC123548 Genomic DNA No translation available. |
RefSeqi | XP_006506701.1, XM_006506638.3 XP_006506702.1, XM_006506639.3 XP_006506703.1, XM_006506640.3 XP_006506704.1, XM_006506641.3 XP_006506705.1, XM_006506642.1 |
Genome annotation databases
Ensembli | ENSMUST00000123405; ENSMUSP00000144936; ENSMUSG00000025702 |
GeneIDi | 71779 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC123548 Genomic DNA No translation available. |
RefSeqi | XP_006506701.1, XM_006506638.3 XP_006506702.1, XM_006506639.3 XP_006506703.1, XM_006506640.3 XP_006506704.1, XM_006506641.3 XP_006506705.1, XM_006506642.1 |
3D structure databases
SMRi | A0A0N4SV35 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 3041, 161 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000123405; ENSMUSP00000144936; ENSMUSG00000025702 |
GeneIDi | 71779 |
Organism-specific databases
CTDi | 220972 |
MGIi | MGI:1919029, Marchf8 |
Phylogenomic databases
GeneTreei | ENSGT00940000158282 |
OrthoDBi | 1222747at2759 |
Miscellaneous databases
BioGRID-ORCSi | 71779, 2 hits in 15 CRISPR screens |
ChiTaRSi | March8, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025702, Expressed in blood and 261 other tissues |
ExpressionAtlasi | A0A0N4SV35, baseline and differential |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR011016, Znf_RING-CH IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF12906, RINGv, 1 hit |
SMARTi | View protein in SMART SM00744, RINGv, 1 hit |
PROSITEi | View protein in PROSITE PS51292, ZF_RING_CH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0N4SV35_MOUSE | |
Accessioni | A0A0N4SV35Primary (citable) accession number: A0A0N4SV35 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 9, 2015 |
Last sequence update: | December 9, 2015 | |
Last modified: | December 2, 2020 | |
This is version 31 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |