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Protein

DNA polymerase III subunit epsilon

Gene

dnaQ

Organism
Buchnera aphidicola (Aphis glycines)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.UniRule annotation

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

Cofactori

Protein has several cofactor binding sites:

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-directed DNA polymeraseUniRule annotation, ExonucleaseUniRule annotation, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA replicationUniRule annotation
LigandMagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase III subunit epsilonUniRule annotation (EC:2.7.7.7UniRule annotation)
Gene namesi
Name:dnaQUniRule annotation
ORF Names:IX46_01305Imported
OrganismiBuchnera aphidicola (Aphis glycines)Imported
Taxonomic identifieri1265350 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000066321 Componenti: Chromosome

Interactioni

Subunit structurei

The DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha,epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 185ExonucleaseInterPro annotationAdd BLAST178

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili205 – 225Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KOiK02342

Family and domain databases

CDDicd06131 DNA_pol_III_epsilon_Ecoli_like, 1 hit
Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR006054 DnaQ
IPR006309 DnaQ_proteo
IPR013520 Exonuclease_RNaseT/DNA_pol3
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF00929 RNase_T, 1 hit
SMARTiView protein in SMART
SM00479 EXOIII, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
TIGRFAMsiTIGR00573 dnaq, 1 hit
TIGR01406 dnaQ_proteo, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0M5JV78-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNNEKKRII VLDTETTGIN NFGKSCINHR IIEIGAIEII NRHFTGNNFH
60 70 80 90 100
VYIQPNRPID PEAIKIHGIT NNFLLDKPLF KHIAQKFFKY IQNTQLVIHN
110 120 130 140 150
ASFDVGFINQ EFSLLKNKTI DISNFCSIID TLKIARKLFP GKKNTLDALC
160 170 180 190 200
NRYKIKNSHR VLHGALLDSF LLGKLYLLMT SGQESMSFCN NIEHGNNYTS
210 220 230 240
FSKWIKNKKK SLKILKANVE ELTLHEKYIN HIKDIKKNNF TN
Length:242
Mass (Da):28,031
Last modified:December 9, 2015 - v1
Checksum:i05B8872A17E363BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009253 Genomic DNA Translation: ALD15203.1
RefSeqiWP_053940211.1, NZ_CP009253.1

Genome annotation databases

EnsemblBacteriaiALD15203; ALD15203; IX46_01305
KEGGibaph:IX46_01305
PATRICifig|1265350.3.peg.243

Similar proteinsi

Entry informationi

Entry nameiA0A0M5JV78_9GAMM
AccessioniPrimary (citable) accession number: A0A0M5JV78
Entry historyiIntegrated into UniProtKB/TrEMBL: December 9, 2015
Last sequence update: December 9, 2015
Last modified: December 20, 2017
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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