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Entry version 37 (12 Aug 2020)
Sequence version 1 (09 Dec 2015)
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Protein

Ribosomal RNA large subunit methyltransferase H

Gene

rlmH

Organism
Bifidobacterium longum
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei76S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei108S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferaseUniRule annotationImported, Transferase
Biological processrRNA processingUniRule annotation
LigandS-adenosyl-L-methionineUniRule annotation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
GCF_000185665-HMP:HMPREF0177_RS03150-MONOMER
GCF_001546275-HMP:HMPREF3231_RS09055-MONOMER
GCF_001719085:B624_RS08690-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase HUniRule annotation (EC:2.1.1.177UniRule annotation)
Alternative name(s):
23S rRNA (pseudouridine1915-N3)-methyltransferaseUniRule annotation
23S rRNA m3Psi1915 methyltransferaseUniRule annotation
rRNA (pseudouridine-N3-)-methyltransferase RlmHUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rlmHUniRule annotationImported
ORF Names:APC1462_1821Imported, APC1476_1911Imported, APC1503_1882Imported, APS65_05030Imported, BBG7_1893Imported, Blongum51A_1680Imported, CYJ39_07500Imported, DPC6316_1782Imported, DPC6317_1804Imported, DW237_09610Imported, DWV47_08800Imported, DWV59_06775Imported, DWV93_09090Imported, DWZ73_08300Imported, DXC63_07480Imported, GBB58_06700Imported, GBC33_07335Imported, GBI83_03735Imported, GBJ99_07370Imported, HMPREF0177_01386Imported, HMPREF3231_02048Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBifidobacterium longumImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri216816 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaBifidobacterialesBifidobacteriaceaeBifidobacterium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000075407 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000265775 Componenti: Unassembled WGS sequence
  • UP000431047 Componenti: Unassembled WGS sequence
  • UP000284732 Componenti: Unassembled WGS sequence
  • UP000283551 Componenti: Unassembled WGS sequence
  • UP000232402 Componenti: Unassembled WGS sequence
  • UP000265840 Componenti: Unassembled WGS sequence
  • UP000234964 Componenti: Unassembled WGS sequence
  • UP000432196 Componenti: Unassembled WGS sequence
  • UP000232637 Componenti: Unassembled WGS sequence
  • UP000286333 Componenti: Unassembled WGS sequence
  • UP000055147 Componenti: Chromosome
  • UP000232654 Componenti: Unassembled WGS sequence
  • UP000429539 Componenti: Unassembled WGS sequence
  • UP000003025 Componenti: Unassembled WGS sequence
  • UP000261288 Componenti: Unassembled WGS sequence
  • UP000070323 Componenti: Unassembled WGS sequence
  • UP000297677 Componenti: Chromosome
  • UP000429224 Componenti: Unassembled WGS sequence
  • UP000232439 Componenti: Unassembled WGS sequence
  • UP000232554 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

UniRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni127 – 132S-adenosyl-L-methionine bindingUniRule annotation6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNA methyltransferase RlmH family.UniRule annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_100552_0_0_11

KEGG Orthology (KO)

More...
KOi
K00783

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1280.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00658, 23SrRNA_methyltr_H, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029028, Alpha/beta_knot_MTases
IPR003742, RlmH-like
IPR029026, tRNA_m1G_MTases_N

The PANTHER Classification System

More...
PANTHERi
PTHR33603, PTHR33603, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02590, SPOUT_MTase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF004505, MT_bac, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF75217, SSF75217, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00246, tRNA_RlmH_YbeA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0M4N4V6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQIDIIAPGR VKERYLRDAI DEYSKRLSRY CKLNIIEVAD EKTPDHASEG
60 70 80 90 100
VDRQIKAREG ERIAKHLKDG AFVIALAING KQLSSEELAA KINDLGLRGT
110 120 130 140 150
SHIQLVIGGS IGLDDAILRR ADFLLSFSKM TFPHQLMRVI LLEQIYRAYK

INAGEPYHK
Length:159
Mass (Da):17,973
Last modified:December 9, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9B57213F36FB68C9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP010453 Genomic DNA Translation: ALE37080.1
ADCN01000033 Genomic DNA Translation: EFV37012.1
WDZR01000015 Genomic DNA Translation: KAB6909281.1
WDWL01000004 Genomic DNA Translation: KAB7073910.1
WDUC01000011 Genomic DNA Translation: KAB7200641.1
WDQS01000016 Genomic DNA Translation: KAB7382012.1
LRPQ01000089 Genomic DNA Translation: KWZ87081.1
LKUQ01000020 Genomic DNA Translation: KYJ81362.1
PJDQ01000014 Genomic DNA Translation: PKC81429.1
PJDR01000019 Genomic DNA Translation: PKC83077.1
PJDT01000028 Genomic DNA Translation: PKC87163.1
PJDY01000026 Genomic DNA Translation: PKC97938.1
PJEF01000014 Genomic DNA Translation: PKD10604.1
PKGP01000007 Genomic DNA Translation: PKY76639.1
CP026999 Genomic DNA Translation: QCH31267.1
QSRZ01000007 Genomic DNA Translation: RGL48485.1
QRZU01000011 Genomic DNA Translation: RGW05507.1
QSAR01000006 Genomic DNA Translation: RGW64310.1
QSAY01000006 Genomic DNA Translation: RGW82270.1
QRIW01000011 Genomic DNA Translation: RHG88203.1
QRPR01000006 Genomic DNA Translation: RHM27484.1

NCBI Reference Sequences

More...
RefSeqi
WP_007053094.1, NZ_WOWU01000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ALE37080; ALE37080; BBG7_1893
AOL11097; AOL11097; B624_1653
EFV37012; EFV37012; HMPREF0177_01386
KWZ87081; KWZ87081; HMPREF3231_02048
KYJ81362; KYJ81362; APS65_05030

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
blx:GS08_09655

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|216816.111.peg.1956

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP010453 Genomic DNA Translation: ALE37080.1
ADCN01000033 Genomic DNA Translation: EFV37012.1
WDZR01000015 Genomic DNA Translation: KAB6909281.1
WDWL01000004 Genomic DNA Translation: KAB7073910.1
WDUC01000011 Genomic DNA Translation: KAB7200641.1
WDQS01000016 Genomic DNA Translation: KAB7382012.1
LRPQ01000089 Genomic DNA Translation: KWZ87081.1
LKUQ01000020 Genomic DNA Translation: KYJ81362.1
PJDQ01000014 Genomic DNA Translation: PKC81429.1
PJDR01000019 Genomic DNA Translation: PKC83077.1
PJDT01000028 Genomic DNA Translation: PKC87163.1
PJDY01000026 Genomic DNA Translation: PKC97938.1
PJEF01000014 Genomic DNA Translation: PKD10604.1
PKGP01000007 Genomic DNA Translation: PKY76639.1
CP026999 Genomic DNA Translation: QCH31267.1
QSRZ01000007 Genomic DNA Translation: RGL48485.1
QRZU01000011 Genomic DNA Translation: RGW05507.1
QSAR01000006 Genomic DNA Translation: RGW64310.1
QSAY01000006 Genomic DNA Translation: RGW82270.1
QRIW01000011 Genomic DNA Translation: RHG88203.1
QRPR01000006 Genomic DNA Translation: RHM27484.1
RefSeqiWP_007053094.1, NZ_WOWU01000001.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiALE37080; ALE37080; BBG7_1893
AOL11097; AOL11097; B624_1653
EFV37012; EFV37012; HMPREF0177_01386
KWZ87081; KWZ87081; HMPREF3231_02048
KYJ81362; KYJ81362; APS65_05030
KEGGiblx:GS08_09655
PATRICifig|216816.111.peg.1956

Phylogenomic databases

HOGENOMiCLU_100552_0_0_11
KOiK00783

Enzyme and pathway databases

BioCyciGCF_000185665-HMP:HMPREF0177_RS03150-MONOMER
GCF_001546275-HMP:HMPREF3231_RS09055-MONOMER
GCF_001719085:B624_RS08690-MONOMER

Family and domain databases

Gene3Di3.40.1280.10, 1 hit
HAMAPiMF_00658, 23SrRNA_methyltr_H, 1 hit
InterProiView protein in InterPro
IPR029028, Alpha/beta_knot_MTases
IPR003742, RlmH-like
IPR029026, tRNA_m1G_MTases_N
PANTHERiPTHR33603, PTHR33603, 1 hit
PfamiView protein in Pfam
PF02590, SPOUT_MTase, 1 hit
PIRSFiPIRSF004505, MT_bac, 1 hit
SUPFAMiSSF75217, SSF75217, 1 hit
TIGRFAMsiTIGR00246, tRNA_RlmH_YbeA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0M4N4V6_BIFLN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0M4N4V6
Secondary accession number(s): E5XZI1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 9, 2015
Last sequence update: December 9, 2015
Last modified: August 12, 2020
This is version 37 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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