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UniProtKB - A0A0M4CXX7 (A0A0M4CXX7_SPHS1)

Entry version 16 (07 Oct 2020)
Sequence version 1 (09 Dec 2015)
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Protein
Submitted name:

Phosphomevalonate kinase

Gene

LH20_17920

Organism
Sphingopyxis sp. (strain 113P3)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseImported, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Phosphomevalonate kinaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:LH20_17920Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSphingopyxis sp. (strain 113P3)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri292913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Alphaproteobacteria › Sphingomonadales › Sphingomonadaceae › Sphingopyxis ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000061305 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 135LPD22InterPro annotationAdd BLAST97
Domaini845 – 925MuF_CInterPro annotationAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni939 – 983DisorderedSequence analysisAdd BLAST45

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili515 – 549Sequence analysisAdd BLAST35
Coiled coili1183 – 1203Sequence analysisAdd BLAST21
Coiled coili1410 – 1437Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		142817at2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040738, LPD22
IPR041131, MuF_C

Pfam protein domain database

More...Pfami		View protein in Pfam
PF18834, LPD22, 1 hit
PF18819, MuF_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0M4CXX7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPPLPGLDY YDQRFRSRPA NEPVARIDPI EAEMRRERDR QTRLDLLLSA 
        60         70         80         90        100
SPDTVGRATT IAKEIGVPPM HVEDRLAEAE KGRHVRRFMS VAERYPAIGK 
       110        120        130        140        150
WAVTQPRGAA AASDDWDSLS LLGKTWRSTR EVATGIFPSL SSGLFTMAEN 
       160        170        180        190        200
VEGAIGAVSD TLDAIDPMPA VAGIFSDLIG TYTGYNPRWD KSFAANQRIQ 
       210        220        230        240        250
REARAKRQAE LAREAEDWRP KSTSWIAREL LAGTESIPMS AAALITRDPK 
       260        270        280        290        300
QAAGVFGTLT GAGEYQKARD AGLDLGSSLA YGARQGAVEA LTEHIPAAKL 
       310        320        330        340        350
LGDIAARSPL GKMLLNQLVR EVPGEQVATL LQDFDQWVTL NPDKTLGEFI 
       360        370        380        390        400
AERPDAARQT LLGTIGAVGT TTAVVRATQK VAEGSAMIAA RRGEADRALR 
       410        420        430        440        450
EGDILAKAGA AAEKSKLRER DPEAFAALMR ELAEDSGATD VYIPAEAIQQ 
       460        470        480        490        500
YMQSDGFDPD SWAEFEEESL EAMATGGDVV MPVERVLTAF PGTPAWEALR 
       510        520        530        540        550
DHMRLSPGGM SRFEAESFNL EVAELRQTME EQAAAVEEYD REMMEAREAL 
       560        570        580        590        600
LTDVTEKLQT AGYTPSVART QAELLAARYE TRAMRKGQRL TGREFADVDV 
       610        620        630        640        650
VQILPEKLAL RQKNDGLDRV IDAMRRGTEG AKRGPSLLEF ISKRGGIDDV 
       660        670        680        690        700
GGDIASMGGD KWHRSAPFRK RLTRSVDKGQ ASMLSAAASD TAPEDVFRAA 
       710        720        730        740        750
ISAGYFPELA GREEGTYDDA LDNRMLLDAI GEELRGNARY AEEVDTTLTD 
       760        770        780        790        800
AAQELATLLA NEGLDPASAT RKQIRDAIAA YSARNANEGR GYLQAGLRDD 
       810        820        830        840        850
IQAAWSGTKT RGFIDLGPVP QALVDFGLPA GKLQIGRGKI NAIANKHDLE 
       860        870        880        890        900
VGDVASLAAM LEQPWAIYPT TLKDSNRVVV ALPVRDRNGD PILCVIEPNG 
       910        920        930        940        950
KVATVTSVYG KKGRGSVTGD DTIRAAIANA RAKGLEVFEG APPARDPEPV 
       960        970        980        990       1000
SGIMPEKRRR PILSLPQNGK PTSLEQSGDE KAPRGRIVFP SEEFTGAALI 
      1010       1020       1030       1040       1050
ELFKSRNLST FLHETGHLWL EELRYDALSE DATNRLKDDW ATVQDWFAAN 
      1060       1070       1080       1090       1100
GHPIENGVIP VEAHEMWARG VEQYLMEGKA PVPALRSIFE QFRAWLTSIY 
      1110       1120       1130       1140       1150
RSVKALRSPL TPEIRRVMDR LIATDDDIAL ASREQSVQPL LTDGTDMTKA 
      1160       1170       1180       1190       1200
EWEAYQRLTA DARIEARGQL LDKTVRDVRA RNTKKYREMA AELREEIEAS 
      1210       1220       1230       1240       1250
VDERPAFRAI AAMRAQPIDR RWVVNMMGEE AAAYMPRGVP PLMRNGGVHP 
      1260       1270       1280       1290       1300
DTIAEQSGFA TAYEMIEALT ELEIAHRTAR EEGDQRGLRE RIIEEELDIM 
      1310       1320       1330       1340       1350
MRDRYGEPLT DGSIEREAIA AVHNDLQGEV IAAEVRVLGR KAGEPPTPYS 
      1360       1370       1380       1390       1400
AAQEWARQKI RSGKVSVEAM PGALQRYARA SKRAAREAEA AYLERNIEGA 
      1410       1420       1430       1440       1450
FRAKQQQMLN NALYSEAKKA HEEVEAARQR LNKIASKRVM KSVDQEYLEQ 
      1460       1470       1480       1490       1500
AQALLEAVDI KRRTQKGITR QGKWEEWSQQ RQAEGYDIVV PSSFEATIGK 
      1510       1520       1530       1540       1550
ENWTRLTVEH FLGLDEAVRQ IIHLGRLKRE LQDGQDKREF ELTVTQAVQA 
      1560       1570       1580       1590       1600
VAKLPQRPPS DLMEPSRWDA IKSKVAAADA ALLKMETVFD WLDSGDSNGI 
      1610       1620       1630       1640       1650
FNRIVFRPLV DAQENERIRM NDILGQLRAA LEKVPADTLK RWSDKITAPE 
      1660       1670       1680       1690       1700
LINRETGNPF VMTREMVIAI ALNTGNSGNY EKLLGGYGWS ATGVEAMLAR 
      1710       1720       1730       1740       1750
VMTQEEWAYV QEVWDIINSL WPDIEAMEKR VNDIAPEKVE ARPVQTKWGV 
      1760       1770       1780       1790       1800
LKGGYYPVVY DPRRNYESES YAAKGDSLFE GIYTRATTPK GFTKERTNVE 
      1810       1820       1830       1840       1850
RPIHLSLGVI HRHVGEVIHD LTHREAIMQA DKFLQARPVM KAVDDSLGPE 
      1860       1870       1880       1890       1900
VRKQFRPWLQ RIANEWAYDR AGQAGVEGFV KKARLNATIV GMGFRATTIL 
      1910       1920       1930       1940       1950
LQAAGYSNSF ETVGLRWVSR RLKDVGNPEA WNFVLEKSKE VRARMDTLDR 
      1960       1970       1980       1990       2000
DIRDNVRKAA GQRNLSAIKK FAFHGIGYMD RVVVIPTWLG AYDKAIAEGM 
      2010       2020       2030       2040       2050
SEDDAVYAAD KAVRQSQGAG AAKDLAAIQS GRGTFGEAAK LLTMFYSYMS 
      2060       2070       2080       2090       2100
AFYQRQRSFA RDVRAAKLSD GPGLLARAWW LFIVPPLLSE LLAGRTPDDD 
      2110       2120       2130       2140       2150
DDESWAEWAL SNIIFQIFGP VPVLRDIGPT LWAKATDRPT FGYRFTPAQG 
      2160       2170       2180       2190       2200
GVESIINVGS DLGKIWRGEE TKRATRNAIE TTGYFTGLTT GQMAVAAQFL 
      2210       2220 
VDVGSGDANP DGIGEWWRGL TTGKTD
Length:2,226
Mass (Da):246,318
Last modified:December 9, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C9DAA87CD4DAD3F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CP009452 Genomic DNA Translation: ALC13838.1

NCBI Reference Sequences

More...RefSeqi		WP_053555339.1, NZ_CP009452.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		ALC13838; ALC13838; LH20_17920

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sphp:LH20_17920

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|292913.6.peg.3643

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009452 Genomic DNA Translation: ALC13838.1
RefSeqiWP_053555339.1, NZ_CP009452.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiALC13838; ALC13838; LH20_17920
KEGGisphp:LH20_17920
PATRICifig|292913.6.peg.3643

Phylogenomic databases

OrthoDBi142817at2

Family and domain databases

InterProiView protein in InterPro
IPR040738, LPD22
IPR041131, MuF_C
PfamiView protein in Pfam
PF18834, LPD22, 1 hit
PF18819, MuF_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0M4CXX7_SPHS1
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0M4CXX7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 9, 2015
Last sequence update: December 9, 2015
Last modified: October 7, 2020
This is version 16 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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