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Entry version 40 (13 Nov 2019)
Sequence version 1 (11 Nov 2015)
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Protein
Submitted name:

clade A/E 93TH057 HIV-1 gp120 core

Gene

HIV-1 Env

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processFusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
clade A/E 93TH057 HIV-1 gp120 coreImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:HIV-1 EnvImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman immunodeficiency virus 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri11676 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesOrterviralesRetroviridaeOrthoretrovirinaeLentivirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

MembraneSAAS annotation, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi11 ↔ 31Combined sources
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi45N-linked (GlcNAc...) asparagineCombined sources1
Disulfide bondi76 ↔ 89Combined sources
Disulfide bondi102 ↔ 131Combined sources
Disulfide bondi112 ↔ 123Combined sources
Glycosylationi118N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi125N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi146N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi160N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi173N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi179N-linked (GlcNAc...) asparagineCombined sources1
Disulfide bondi180 ↔ 199Combined sources
Glycosylationi202N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi223N-linked (GlcNAc...) asparagineCombined sources1
Disulfide bondi245 ↔ 306Combined sources
Disulfide bondi252 ↔ 279Combined sources
Glycosylationi253N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi259N-linked (GlcNAc...) asparagineCombined sources1
Disulfide bondi262 ↔ 271Combined sources
Glycosylationi272N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi309N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi322N-linked (GlcNAc...) asparagineCombined sources1

Keywords - PTMi

Disulfide bondSAAS annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 80GP120InterPro annotationAdd BLAST80
Domaini82 – 353GP120InterPro annotationAdd BLAST272

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili43 – 63Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.170.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036377 Gp120_core_sf
IPR000777 HIV1_Gp120

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00516 GP120, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56502 SSF56502, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0M3KKW9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VWKDADTTLF CASDAKAHET EVHNVWATHA CVPTDPNPQE IHLENVTENF
60 70 80 90 100
NMWKNNMVEQ MQEDVISLWD QSLQPCVKLT GGSVIKQACP KISFDPIPIH
110 120 130 140 150
YCTPAGYVIL KCNDKNFNGT GPCKNVSSVQ CTHGIKPVVS TQLLLNGSLA
160 170 180 190 200
EEEIIIRSEN LTNNAKTIIV HLNKSVEINC TRPSNGGSGS GGDIRKAYCE
210 220 230 240 250
INGTKWNKVL KQVTEKLKEH FNNKTIIFQP PSGGDLEITM HHFNCRGEFF
260 270 280 290 300
YCNTTQLFNN TCIGNETMKG CNGTITLPCK IKQIINMWQG TGQAMYAPPI
310 320 330 340 350
DGKINCVSNI TGILLTRDGG ANNTSNETFR PGGGNIKDNW RSELYKYKVV

QIE
Length:353
Mass (Da):39,169
Last modified:November 11, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE65E0E30AFE2A5C
GO

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3U7YX-ray2.45G1-80[»]
G83-185[»]
G192-353[»]
4DKUX-ray2.49A/B1-80[»]
A/B83-185[»]
A/B192-353[»]
4DKVX-ray2.18A/B1-80[»]
A/B83-185[»]
A/B192-353[»]
4DVSX-ray2.10A/B1-353[»]
4DVTX-ray2.40A/B1-353[»]
4DVVX-ray1.94A/B1-353[»]
4DVWX-ray2.20A/B1-353[»]
4DVXX-ray2.40A/B1-353[»]
4RZ8X-ray1.90A/B/C/D1-80[»]
A/B/C/D83-185[»]
A/B/C/D192-353[»]
4S1QX-ray2.40G1-353[»]
4S1RX-ray3.21G1-353[»]
4S1SX-ray3.39G1-353[»]
4YBLX-ray3.10A/G1-141[»]
4YC2X-ray3.02A/G1-141[»]
5CD5X-ray3.40A1-353[»]
5F96X-ray2.24G1-353[»]
5F9OX-ray1.86G1-352[»]
5F9WX-ray2.89A/G1-353[»]
5FCUX-ray1.85G1-140[»]
5KJRX-ray2.98G1-353[»]
5TE6X-ray2.40G1-353[»]
5U6EX-ray2.10A/B1-353[»]
5UEMX-ray2.70G1-353[»]
5UWEX-ray3.19G1-353[»]
5W4LX-ray2.92A/G1-353[»]
5WB9X-ray2.40G1-353[»]
6BCKX-ray2.70G1-353[»]
6MFPX-ray3.00A/G1-353[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Family and domain databases

Gene3Di2.170.40.20, 1 hit
InterProiView protein in InterPro
IPR036377 Gp120_core_sf
IPR000777 HIV1_Gp120
PfamiView protein in Pfam
PF00516 GP120, 2 hits
SUPFAMiSSF56502 SSF56502, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0M3KKW9_9HIV1
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0M3KKW9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 11, 2015
Last sequence update: November 11, 2015
Last modified: November 13, 2019
This is version 40 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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