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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Clostridium botulinum
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotationSAAS annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotationSAAS annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route).UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation, Multifunctional enzymeUniRule annotationSAAS annotation, TransferaseUniRule annotationSAAS annotationImported
Biological processPurine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayi
UPA00074;UER00133

UPA00074;UER00135

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
ORF Names:ADT22_05355Imported
OrganismiClostridium botulinumImported
Taxonomic identifieri1491 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000037363 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 128MGSInterPro annotationAdd BLAST115

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di3.40.140.20, 2 hits
3.40.50.1380, 1 hit
HAMAPiMF_00139 PurH, 1 hit
InterProiView protein in InterPro
IPR024051 AICAR_Tfase_dup_dom_sf
IPR016193 Cytidine_deaminase-like
IPR011607 MGS-like_dom
IPR036914 MGS-like_dom_sf
IPR002695 PurH-like
PANTHERiPTHR11692 PTHR11692, 1 hit
PfamiView protein in Pfam
PF01808 AICARFT_IMPCHas, 1 hit
PF02142 MGS, 1 hit
PIRSFiPIRSF000414 AICARFT_IMPCHas, 1 hit
SMARTiView protein in SMART
SM00798 AICARFT_IMPCHas, 1 hit
SM00851 MGS, 1 hit
SUPFAMiSSF52335 SSF52335, 1 hit
SSF53927 SSF53927, 1 hit
TIGRFAMsiTIGR00355 purH, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0M1LX65-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKRALISVF NKDGVLDFAK FLVSKDIEIV STGGTYKYLK ENGIDVIEIN
60 70 80 90 100
EVTNFPEMLD GRVKTLHPLV HAGILAIRDN KEHMKVLEER EIHTIDYVVV
110 120 130 140 150
NLYPFFEKVK EDLTFEEKVE FIDIGGPTML RAAAKNFQDV VVISNINDYE
160 170 180 190 200
VVKSEIENHG QVSLKTKKKL AGKVFNLMSA YDGAIANFML ADEEEYPEYL
210 220 230 240 250
SVSYKKMQNL RYGENSHQSA AVYSSTMVDG AMNTFETLNG KELSYNNFKD
260 270 280 290 300
VDIAWKCANE FDEPACCALK HNTPCGVATG ENSYEAYMKA YEVDPTSIFG
310 320 330 340 350
GIIGFNRKVD KKTAEEMVKI FLEVIAAPDY DEDALEVLKT KKNLRVLKFH
360 370 380 390 400
NTPKAEKCMV TVDGAILVQD EDNKLIDEIK VVTEKKPSDE EMEDLLFGMK
410 420 430 440 450
VVKYVKSNAI VVAHNGIALG IGGGQVNRIW PTEDALRRGK GATILASDAF
460 470 480 490 500
FPFRDVVDKA AEGGIKAIIQ PGGSMRDQES IDACNEHGIA MVFTGFRHFK

H
Length:501
Mass (Da):56,054
Last modified:November 11, 2015 - v1
Checksum:i1892FB053EDB914A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LHUM01000023 Genomic DNA Translation: KOR61965.1
RefSeqiWP_053342334.1, NZ_NPMY01000016.1

Genome annotation databases

EnsemblBacteriaiKOR61965; KOR61965; ADT22_05355
PATRICifig|1491.443.peg.1677

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LHUM01000023 Genomic DNA Translation: KOR61965.1
RefSeqiWP_053342334.1, NZ_NPMY01000016.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiKOR61965; KOR61965; ADT22_05355
PATRICifig|1491.443.peg.1677

Enzyme and pathway databases

UniPathwayi
UPA00074;UER00133

UPA00074;UER00135

Family and domain databases

Gene3Di3.40.140.20, 2 hits
3.40.50.1380, 1 hit
HAMAPiMF_00139 PurH, 1 hit
InterProiView protein in InterPro
IPR024051 AICAR_Tfase_dup_dom_sf
IPR016193 Cytidine_deaminase-like
IPR011607 MGS-like_dom
IPR036914 MGS-like_dom_sf
IPR002695 PurH-like
PANTHERiPTHR11692 PTHR11692, 1 hit
PfamiView protein in Pfam
PF01808 AICARFT_IMPCHas, 1 hit
PF02142 MGS, 1 hit
PIRSFiPIRSF000414 AICARFT_IMPCHas, 1 hit
SMARTiView protein in SMART
SM00798 AICARFT_IMPCHas, 1 hit
SM00851 MGS, 1 hit
SUPFAMiSSF52335 SSF52335, 1 hit
SSF53927 SSF53927, 1 hit
TIGRFAMsiTIGR00355 purH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0M1LX65_CLOBO
AccessioniPrimary (citable) accession number: A0A0M1LX65
Entry historyiIntegrated into UniProtKB/TrEMBL: November 11, 2015
Last sequence update: November 11, 2015
Last modified: June 20, 2018
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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