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Protein

Crossover junction endodeoxyribonuclease RuvC

Gene

ruvC

Organism
Acinetobacter sp. C15
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8MagnesiumUniRule annotation1
Metal bindingi67MagnesiumUniRule annotation1
Metal bindingi139MagnesiumUniRule annotation1
Metal bindingi142MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, NucleaseUniRule annotationSAAS annotation
Biological processDNA damage, DNA recombinationUniRule annotationSAAS annotation, DNA repairUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvCUniRule annotationSAAS annotation (EC:3.1.22.4UniRule annotationSAAS annotation)
Alternative name(s):
Holliday junction nuclease RuvCUniRule annotation
Holliday junction resolvase RuvCUniRule annotation
Gene namesi
Name:ruvCUniRule annotation
ORF Names:ABW55_14540Imported
OrganismiAcinetobacter sp. C15Imported
Taxonomic identifieri1661746 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
Proteomesi
  • UP000050666 Componenti: Unassembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00034 RuvC, 1 hit
InterProiView protein in InterPro
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR020563 X-over_junc_endoDNase_Mg_BS
IPR002176 X-over_junc_endoDNase_RuvC
PANTHERiPTHR30194 PTHR30194, 1 hit
PfamiView protein in Pfam
PF02075 RuvC, 1 hit
PRINTSiPR00696 RSOLVASERUVC
SUPFAMiSSF53098 SSF53098, 1 hit
TIGRFAMsiTIGR00228 ruvC, 1 hit
PROSITEiView protein in PROSITE
PS01321 RUVC, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0M1HV58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLIIGIDPG SRLTGYGIIE KNGNDLRFID AGTIRTETQG MPERLKRIFA
60 70 80 90 100
GVERIVKFHG PTEAAVEQVF MAQNPDSALK LGQARGAAIA ALVNLDLDVA
110 120 130 140 150
EYTARQIKQS VVGYGAADKE QVQMMVMRIL SLTIKPQADA ADALAAAICH
160 170 180
AHASGNMSKF AVLNALGGMA RGRSRYSSRR R
Length:181
Mass (Da):19,468
Last modified:November 11, 2015 - v1
Checksum:i4A313CBA3EFB4E94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LDWD01000086 Genomic DNA Translation: KOR12370.1
RefSeqiWP_025095186.1, NZ_LDWD01000086.1

Genome annotation databases

EnsemblBacteriaiKOR12370; KOR12370; ABW55_14540
GeneIDi31754771
PATRICifig|1661746.3.peg.2741

Similar proteinsi

Entry informationi

Entry nameiA0A0M1HV58_9GAMM
AccessioniPrimary (citable) accession number: A0A0M1HV58
Entry historyiIntegrated into UniProtKB/TrEMBL: November 11, 2015
Last sequence update: November 11, 2015
Last modified: May 23, 2018
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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