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Entry version 37 (03 Jul 2019)
Sequence version 1 (11 Nov 2015)
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Protein

Peptide chain release factor 1

Gene

prfA

Organism
Salmonella enterica (Salmonella choleraesuis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein biosynthesisUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptide chain release factor 1UniRule annotation
Short name:
RF-1UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:prfAUniRule annotationImported
ORF Names:A7D45_13800Imported, A7E06_04090Imported, A7K84_10675Imported, A7S51_02480Imported, AL463_18570Imported, ASQ14_17125Imported, BA086_20270Imported, BUJ17_0000685Imported, BUJ19_004285Imported, C4860_10875Imported, CHC34_13525Imported, CHE19_11385Imported, CRE05_14850Imported, D6N55_03735Imported, D9762_17550Imported, D9O31_11870Imported, DMT70_06115Imported, DTA53_20420Imported, EAK82_19590Imported, ED033_22735Imported, ED173_19290Imported, EEM47_18295Imported, EEN88_19870Imported, IN95_16280Imported, KO51_01550Imported, NCTC10252_03016Imported, NCTC6385_02496Imported, NCTC9854_02011Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmonella enterica (Salmonella choleraesuis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28901 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000053698 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000245285 Componenti: Unassembled WGS sequence
  • UP000271210 Componenti: Unassembled WGS sequence
  • UP000254463 Componenti: Unassembled WGS sequence
  • UP000266289 Componenti: Unassembled WGS sequence
  • UP000279984 Componenti: Unassembled WGS sequence
  • UP000279951 Componenti: Unassembled WGS sequence
  • UP000282157 Componenti: Unassembled WGS sequence
  • UP000055793 Componenti: Chromosome
  • UP000276644 Componenti: Unassembled WGS sequence
  • UP000277926 Componenti: Unassembled WGS sequence
  • UP000260687 Componenti: Unassembled WGS sequence
  • UP000254597 Componenti: Unassembled WGS sequence
  • UP000179758 Componenti: Unassembled WGS sequence
  • UP000215575 Componenti: Unassembled WGS sequence
  • UP000275224 Componenti: Unassembled WGS sequence
  • UP000245912 Componenti: Unassembled WGS sequence
  • UP000279516 Componenti: Unassembled WGS sequence
  • UP000282366 Componenti: Unassembled WGS sequence
  • UP000281141 Componenti: Unassembled WGS sequence
  • UP000267228 Componenti: Unassembled WGS sequence
  • UP000268728 Componenti: Unassembled WGS sequence
  • UP000254773 Componenti: Unassembled WGS sequence
  • UP000281163 Componenti: Unassembled WGS sequence
  • UP000251994 Componenti: Chromosome
  • UP000280230 Componenti: Unassembled WGS sequence
  • UP000252033 Componenti: Chromosome
  • UP000268139 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei235N5-methylglutamineUniRule annotation1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Methylated by PrmC. Methylation increases the termination efficiency of RF1.UniRule annotation

Keywords - PTMi

MethylationUniRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini228 – 244RF_PROK_IInterPro annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni284 – 313DisorderedSequence analysisAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili75 – 98Sequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi286 – 313PolarSequence analysisAdd BLAST28

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the prokaryotic/mitochondrial release factor family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_00093 Rel_fac_1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005139 PCRF
IPR000352 Pep_chain_release_fac_I
IPR004373 PrfA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03462 PCRF, 1 hit
PF00472 RF-1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00937 PCRF, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00019 prfA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00745 RF_PROK_I, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0M0PH35-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPSIVAKLE ALHERHEEVQ ALLGDAGIIA DQDRFRALSR EYAQLSDVSR
60 70 80 90 100
CFTDWQQVQD DIETAQMMLD DPEMREMAQE ELREAKEKSE QLEQQLQVLL
110 120 130 140 150
LPKDPDDERN AFLEVRAGTG GDEAALFAGD LFRMYSRYAE ARRWRVEIMS
160 170 180 190 200
MSEGEHGGYK EIIAKISGDG VYGRLKFESG GHRVQRVPAT ESQGRIHTSA
210 220 230 240 250
CTVAVMPELP EAELPDINPA DLRIDTFRSS GAGGQHVNTT DSAIRITHLP
260 270 280 290 300
TGIVVECQDE RSQHKNKAKA LSVLGARIHA AETAKRQQAE ASTRRNLLGS
310 320 330 340 350
GDRSDRNRTY NFPQGRVTDH RINLTLYRLD ETMEGKLDML IEPIVQEHQA
360
DLLAALSEQE
Length:360
Mass (Da):40,461
Last modified:November 11, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67AF15BF7ADB6755
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP014051 Genomic DNA Translation: AMG27701.1
CP030185 Genomic DNA Translation: AXD19157.1
CP030219 Genomic DNA Translation: AXD71886.1
JYST01000032 Genomic DNA Translation: KTP64070.1
RMEA01000110 Genomic DNA Translation: MER45069.1
RNGN01000089 Genomic DNA Translation: MFX65005.1
ROVY01000072 Genomic DNA Translation: MHI23755.1
RNUA01000103 Genomic DNA Translation: MHT00011.1
RSMR01000001 Genomic DNA Translation: MIK90313.1
RSTN01000017 Genomic DNA Translation: MIU21367.1
RSVA01000009 Genomic DNA Translation: MIV01913.1
RSUV01000002 Genomic DNA Translation: MIV42765.1
RSUZ01000027 Genomic DNA Translation: MIV65337.1
RTGA01000008 Genomic DNA Translation: MJI74020.1
RTRY01000027 Genomic DNA Translation: MJX49157.1
RUCL01000004 Genomic DNA Translation: MKJ49948.1
RVIJ01000023 Genomic DNA Translation: MLW02359.1
RWAH01000009 Genomic DNA Translation: MMS77252.1
MLTE01000001 Genomic DNA Translation: OHJ56895.1
NLBR02000001 Genomic DNA Translation: PUU14061.1
QDLQ01000006 Genomic DNA Translation: PVI97901.1
PDBK01000018 Genomic DNA Translation: RFR80873.1
NMUD03000001 Genomic DNA Translation: RII49553.1
QWJL01000011 Genomic DNA Translation: RIP27550.1
RDPV01000013 Genomic DNA Translation: RNM56812.1
UGWI01000001 Genomic DNA Translation: SUF37723.1
UGWP01000004 Genomic DNA Translation: SUF57737.1
UGWV01000002 Genomic DNA Translation: SUF95545.1

NCBI Reference Sequences

More...
RefSeqi
WP_000804703.1, NZ_UGWT01000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
GAR73024; GAR73024; NGUA18_00898
KOP03044; KOP03044; AL032_09635
KTM89867; KTM89867; IN36_11250
KTO49237; KTO49237; IN69_03735
KTP64070; KTP64070; IN95_16280
OAG47235; OAG47235; A6C39_06475

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|28901.1106.peg.2594

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP014051 Genomic DNA Translation: AMG27701.1
CP030185 Genomic DNA Translation: AXD19157.1
CP030219 Genomic DNA Translation: AXD71886.1
JYST01000032 Genomic DNA Translation: KTP64070.1
RMEA01000110 Genomic DNA Translation: MER45069.1
RNGN01000089 Genomic DNA Translation: MFX65005.1
ROVY01000072 Genomic DNA Translation: MHI23755.1
RNUA01000103 Genomic DNA Translation: MHT00011.1
RSMR01000001 Genomic DNA Translation: MIK90313.1
RSTN01000017 Genomic DNA Translation: MIU21367.1
RSVA01000009 Genomic DNA Translation: MIV01913.1
RSUV01000002 Genomic DNA Translation: MIV42765.1
RSUZ01000027 Genomic DNA Translation: MIV65337.1
RTGA01000008 Genomic DNA Translation: MJI74020.1
RTRY01000027 Genomic DNA Translation: MJX49157.1
RUCL01000004 Genomic DNA Translation: MKJ49948.1
RVIJ01000023 Genomic DNA Translation: MLW02359.1
RWAH01000009 Genomic DNA Translation: MMS77252.1
MLTE01000001 Genomic DNA Translation: OHJ56895.1
NLBR02000001 Genomic DNA Translation: PUU14061.1
QDLQ01000006 Genomic DNA Translation: PVI97901.1
PDBK01000018 Genomic DNA Translation: RFR80873.1
NMUD03000001 Genomic DNA Translation: RII49553.1
QWJL01000011 Genomic DNA Translation: RIP27550.1
RDPV01000013 Genomic DNA Translation: RNM56812.1
UGWI01000001 Genomic DNA Translation: SUF37723.1
UGWP01000004 Genomic DNA Translation: SUF57737.1
UGWV01000002 Genomic DNA Translation: SUF95545.1
RefSeqiWP_000804703.1, NZ_UGWT01000001.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiGAR73024; GAR73024; NGUA18_00898
KOP03044; KOP03044; AL032_09635
KTM89867; KTM89867; IN36_11250
KTO49237; KTO49237; IN69_03735
KTP64070; KTP64070; IN95_16280
OAG47235; OAG47235; A6C39_06475
PATRICifig|28901.1106.peg.2594

Family and domain databases

HAMAPiMF_00093 Rel_fac_1, 1 hit
InterProiView protein in InterPro
IPR005139 PCRF
IPR000352 Pep_chain_release_fac_I
IPR004373 PrfA
PfamiView protein in Pfam
PF03462 PCRF, 1 hit
PF00472 RF-1, 1 hit
SMARTiView protein in SMART
SM00937 PCRF, 1 hit
TIGRFAMsiTIGR00019 prfA, 1 hit
PROSITEiView protein in PROSITE
PS00745 RF_PROK_I, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0M0PH35_SALER
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0M0PH35
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 11, 2015
Last sequence update: November 11, 2015
Last modified: July 3, 2019
This is version 37 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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