Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heme-degrading monooxygenase

Gene

isdG

Organism
Bacillus okuhidensis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the biliverdin in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Protoheme + 3 [reduced NADPH--hemoprotein reductase] + 3 O2 = biliverdin + Fe2+ + CO + 3 [oxidized NADPH--hemoprotein reductase] + 3 H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6IronUniRule annotation1
Sitei66Transition state stabilizerUniRule annotation1
Metal bindingi76Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenaseUniRule annotationImported, Oxidoreductase
LigandHemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heme-degrading monooxygenaseUniRule annotation (EC:1.14.14.18UniRule annotation)
Alternative name(s):
Heme oxygenaseUniRule annotation
Iron-regulated surface determinantUniRule annotation
Iron-responsive surface determinantUniRule annotation
Gene namesi
Name:isdGUniRule annotation
ORF Names:AMD02_03335Imported
OrganismiBacillus okuhidensisImported
Taxonomic identifieri136160 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000037240 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0A0M0KGR6
SMRiA0A0M0KGR6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 92ABMInterPro annotationAdd BLAST91

Sequence similaritiesi

Belongs to the antibiotic biosynthesis monooxygenase family. Heme-degrading monooxygenase IsdG subfamily.UniRule annotation

Family and domain databases

HAMAPiMF_01272 Heme_degrading_monooxygenase, 1 hit
InterProiView protein in InterPro
IPR007138 ABM_dom
IPR011008 Dimeric_a/b-barrel
IPR023953 IsdG
PfamiView protein in Pfam
PF03992 ABM, 1 hit
SUPFAMiSSF54909 SSF54909, 1 hit
PROSITEiView protein in PROSITE
PS51725 ABM, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0M0KGR6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVIVTNTSKI TKGNGEKLIE RFNKVGKVEF MEGFLGLEVL LTENTKDFDE
60 70 80 90 100
VTVVTRWNTK DDFKNWTKSS AFRDAHSKRE VPEYILENKI SFYEVKVVRG
110
PLTAAEAGND SQAQAQ
Length:116
Mass (Da):13,175
Last modified:November 11, 2015 - v1
Checksum:i87F6CFB28A691023
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LILD01000001 Genomic DNA Translation: KOO37994.1

Genome annotation databases

EnsemblBacteriaiKOO37994; KOO37994; AMD02_03335
PATRICifig|136160.3.peg.909

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LILD01000001 Genomic DNA Translation: KOO37994.1

3D structure databases

ProteinModelPortaliA0A0M0KGR6
SMRiA0A0M0KGR6
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiKOO37994; KOO37994; AMD02_03335
PATRICifig|136160.3.peg.909

Family and domain databases

HAMAPiMF_01272 Heme_degrading_monooxygenase, 1 hit
InterProiView protein in InterPro
IPR007138 ABM_dom
IPR011008 Dimeric_a/b-barrel
IPR023953 IsdG
PfamiView protein in Pfam
PF03992 ABM, 1 hit
SUPFAMiSSF54909 SSF54909, 1 hit
PROSITEiView protein in PROSITE
PS51725 ABM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0M0KGR6_9BACI
AccessioniPrimary (citable) accession number: A0A0M0KGR6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 11, 2015
Last sequence update: November 11, 2015
Last modified: September 27, 2017
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again