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Entry version 20 (02 Jun 2021)
Sequence version 1 (11 Nov 2015)
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Protein

FERM domain-containing protein

Gene

AMSG_06353

Organism
Thecamonas trahens ATCC 50062
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FERM domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:AMSG_06353Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiThecamonas trahens ATCC 50062Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri461836 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaApusozoaApusomonadidaeThecamonas
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000054408 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
529818.AMSG_06353T0

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini123 – 437FERMInterPro annotationAdd BLAST315

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni462 – 482DisorderedSequence analysisAdd BLAST21
Regioni1204 – 1225DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2450 – 2473Sequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi464 – 481Basic and acidic residuesSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4261, Eukaryota

Database of Orthologous Groups

More...
OrthoDBi
527681at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473, FERM_B-lobe, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019749, Band_41_domain
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR000299, FERM_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00373, FERM_M, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295, B41, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031, SSF47031, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50057, FERM_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0L0DFV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHKPCEGYHV SLTPLTLEVQ VYEVDAGRGR QVAAGEPQTV TLSPLATVLS
60 70 80 90 100
ACNEMALALD GAVDGQNSSP HSPFQGWGLY RLIPDTDRDK DADESYGHLD
110 120 130 140 150
YEATLAAAGV TTHTSLAFLC RRVVVPVRIG PNGPLVSVPI DEAWSVYEIV
160 170 180 190 200
DEIAAAHDSV LHPEEYSFCK ADGHWLVGSL SLPAQRAWSS LQTWPDAPAE
210 220 230 240 250
LVLTRKLYFI EAHAEALANL GPDAPDATLH LLYREASHLV TSGALPVTEK
260 270 280 290 300
EAILLAGLAL QIAHGPRANA PPDALPQEPK DLACFLPPEL AADVGAKLAR
310 320 330 340 350
KIARKHATFA TTPRGLALSK YIKLVRSNPN YGWTFWPMKE RVKAGRRFRL
360 370 380 390 400
VPRLLGLSGS GLKILNAKRS RELVVAAWLV IESVSGSDVG LGPSVVFNIN
410 420 430 440 450
NPSYADEPLV IVVESDAHVR DIIGFCNDYV QLATRRSLAS ELVLTSCASL
460 470 480 490 500
ASLSQPSWDA LVEPTSRRDA DSERSEPDLE ANHALPTHFT LNRLRGLDHA
510 520 530 540 550
GSSSSVARSS SLSSLPAYVS EQWDSLLVAP QVDAYTSTTS LFTTEFTTGS
560 570 580 590 600
EEEGVLGRAL QLQNAASAST FFTSGMYFLP LLDDAPPTME KLRLSAKASL
610 620 630 640 650
AAALKPFSDL AATGKAALAS GVSDGDEPSP SHALLVMAAS GELARDALAS
660 670 680 690 700
LALALLELVM AAAGDTTNLL LPEAAAASAE LAFDALHELV ARLAAFAGVA
710 720 730 740 750
HLVRSQLPDA DGAYAELWVP ASQASGWRVP GELMQATELL EAASAAVCSV
760 770 780 790 800
VADARAVLIA ASHALHHMEE LAPEAPPSRA NTAAGAVVAD AIAIPEEQTS
810 820 830 840 850
ALLTSGKRAG SAIARLATLL GVSPLAADLV DELDTQAQAS SAAALALTNA
860 870 880 890 900
TAHDAFATLA RTRASSLRVE LNALPDLTRM LQRSVGIVSA AIKLGPVHHV
910 920 930 940 950
VAAKIKVASA VVSSTVRSLP HELPVNVPPL REAIISSLSA YQAAVDDVRP
960 970 980 990 1000
KVQPLTLTAR DACLALINAS AAVLAELPRL DGDAAALRKA SLAVAGALAS
1010 1020 1030 1040 1050
VGHCLRNAIT ILDSNGSHLV LLKQLSAVSR LLVTANGLAS QPAPPADQMS
1060 1070 1080 1090 1100
EVLVRASALG RWLHLDCDYV LATHDLKETL AGSLVTAARL VVAEQAESDM
1110 1120 1130 1140 1150
HMTLGRDVSE LRSDLARLAL APRSMRAADA LFSNVSRYVA HASAVVAAAA
1160 1170 1180 1190 1200
GAPTAELTAF SDSLARLAVL QQAAVQHSMA AMIAMYISDI DAARNRVCDA
1210 1220 1230 1240 1250
LPSDEALDEP QTAGGEGSPT SGDMPAFSDS CSSDAFFASG SVADLLEALA
1260 1270 1280 1290 1300
EAEPGVDVHD DDELLGSSTA SLGAQADALV ADIDSLLDQL GVESLAEAMD
1310 1320 1330 1340 1350
DDSVAISGSG TRASVAALER ELAQSSSLAE AVGHYNATVS SLEASGAAVY
1360 1370 1380 1390 1400
AAARHVASLP NARARASYAA RAAMDIHSAV VDARLLVATV MAMWPKIYSQ
1410 1420 1430 1440 1450
QAVARLKNVT LRFLSALGAL LAVVRDLVSA VDGHVEERIA ECKAAMATLK
1460 1470 1480 1490 1500
TAPPGLGMLS VLADELSEAL DELRNPGVAS SDTSDDGARS LDDIVDVAEQ
1510 1520 1530 1540 1550
AVDAALRDGP GSIPRAHGGG GEQLGKTTAE QGFSELEAIL RKCARLVTAT
1560 1570 1580 1590 1600
LDELVTRPET SLNDVEAGAQ LVAQVMRALT TCVVGLRGTI QLAQEAPALR
1610 1620 1630 1640 1650
ASLAALVSKV RTKVDDARAH VLAGKGGLPG ESVRDNAGPW MAAFDEFFAA
1660 1670 1680 1690 1700
FDAAVLAAQG SSGQTGLDVQ RAVETATAGA ARLEMSELGE TERASDKRVA
1710 1720 1730 1740 1750
SELRSVLDSS ETMQATLNGM MPLVSWQGEA SARSGTWPGL DGKVPELAVQ
1760 1770 1780 1790 1800
SAIALANWVE GTVRCVEVLG GVPAGVAPTP PSSPAGAQAP APAVVPTRPV
1810 1820 1830 1840 1850
WEAISSEFKA VMVALTTLKE LADTPGAVAR NVRAGYTQLV LAVRDILLVL
1860 1870 1880 1890 1900
KEGVVTDVAE PGWLVKSEGE AKMLRKAGSA LKTAAMKVVK HCDTQLKALR
1910 1920 1930 1940 1950
PTQPVAGVLK AKAFRKAFKA TVSKLLAVKT AAEEIECVPA VSRGRLGGRG
1960 1970 1980 1990 2000
RAVPAFTSVT QVGERLLASG GQASWVLDLS GDEVAALCEL VCDGRVLARL
2010 2020 2030 2040 2050
GRGAALAVVD ALASLKTLAE PVDAVVSVAT ACAALEHACD MVDAVRGSVA
2060 2070 2080 2090 2100
LLSPTTVGAL EVLVQARQLL RAIEDATSAS KTNAGAQLDA MMSAAADAFL
2110 2120 2130 2140 2150
AEIDRVDDAL GGYAEVVASG SMGVNFVAAR AEVCEALGSV ADVLGSGVCA
2160 2170 2180 2190 2200
SRAQLRALSR ELSTLVRDGV VPLVSCVLSS PLCADKECVS KAQAKSGEAI
2210 2220 2230 2240 2250
CQVRKVFEAD ALALLDAHAW RSSLIATMGK YVGDASEVDS SVVLPGLGYS
2260 2270 2280 2290 2300
DYVRKTKSHV VESVQAAQSL IDAAKCEQGR LGVAARTLVE ATEGVLKCVC
2310 2320 2330 2340 2350
GALSQTPASA SDVLDAVRKA SKTLAWTVAR LVETCVDLAE ASKADRASDA
2360 2370 2380 2390 2400
GRAAVISTSQ RLVDAVSSLM CELKAGAVDA QRQRAALDAS AALGSQLKQT
2410 2420 2430 2440 2450
RLVLQSRSSG SASAGASEAL GAAAEDALMI FLEEGVVETL GRAETEASVA
2460 2470 2480 2490 2500
DALENAAKQL ATAVAQLVEL ANAVETDVGS GVCKAGVEVV TAFCAAGADA
2510 2520 2530 2540 2550
AAHCGARQSS KRDAKLVSAV SSRVMALVRA VRAASEAASR MSSEVTALAA
2560 2570 2580 2590 2600
RVSSDVEALA ELAALDDDGD EWCDAAAREQ GAARVGAALR GLLDAIGQVW
2610 2620 2630 2640 2650
LGGASRSRAS VLAAGHHVAS RVEGVVSAMR ASAAALGRDW VLLSGEVWQA
2660 2670 2680 2690 2700
AEEAHEVVER LLESEVAASA AETAWAAVVS AMIVAASASR LDGPGDASMA
2710 2720 2730 2740 2750
AVSVMEACAE NVAGVSGDSE MSNLAHGAVG AVVMLTKVAL LGLAEAEGLG
2760 2770 2780 2790 2800
FADGATREEL AGCVRGVASA LESLAFVAVA SGETEEAGQA YSEAVNRVSA
2810 2820
AVVKLISANN ELVARGGACA RR
Length:2,822
Mass (Da):291,265
Last modified:November 11, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA6C7DAC25C0655D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GL349460 Genomic DNA Translation: KNC50208.1

NCBI Reference Sequences

More...
RefSeqi
XP_013757043.1, XM_013901589.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
KNC50208; KNC50208; AMSG_06353

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25565532

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL349460 Genomic DNA Translation: KNC50208.1
RefSeqiXP_013757043.1, XM_013901589.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi529818.AMSG_06353T0

Genome annotation databases

EnsemblProtistsiKNC50208; KNC50208; AMSG_06353
GeneIDi25565532

Phylogenomic databases

eggNOGiKOG4261, Eukaryota
OrthoDBi527681at2759

Family and domain databases

CDDicd14473, FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
InterProiView protein in InterPro
IPR019749, Band_41_domain
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR000299, FERM_domain
PfamiView protein in Pfam
PF00373, FERM_M, 1 hit
SMARTiView protein in SMART
SM00295, B41, 1 hit
SUPFAMiSSF47031, SSF47031, 1 hit
PROSITEiView protein in PROSITE
PS50057, FERM_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0L0DFV4_THETB
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0L0DFV4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 11, 2015
Last sequence update: November 11, 2015
Last modified: June 2, 2021
This is version 20 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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