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Protein

GDP-L-fucose synthase

Gene

fcl

Organism
Helicobacter pylori (Campylobacter pylori)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

GDP-beta-L-fucose + NADP+ = GDP-4-dehydro-alpha-D-rhamnose + NADPH.UniRule annotation

Pathwayi: GDP-L-fucose biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes GDP-L-fucose from GDP-alpha-D-mannose.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (nolK), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (nolK), GDP-L-fucose synthase (nolK), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (nolK), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (wbcJ), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (nolK), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (nolK), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (nolK), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (nolK), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (nolK), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (nolK), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (nolK), GDP-L-fucose synthase (nolK), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (nolK), GDP-L-fucose synthase (nolK), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (nolK), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (nolK), GDP-L-fucose synthase (nolK), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (wbcJ), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (nolK), GDP-L-fucose synthase (nolK), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl), GDP-L-fucose synthase (fcl)
This subpathway is part of the pathway GDP-L-fucose biosynthesis via de novo pathway, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes GDP-L-fucose from GDP-alpha-D-mannose, the pathway GDP-L-fucose biosynthesis via de novo pathway and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei107Important for catalytic activityUniRule annotation1
Sitei109Important for catalytic activityUniRule annotation1
Active sitei136Proton donor/acceptorUniRule annotation1
Binding sitei140NADPUniRule annotation1
Binding sitei179NADPUniRule annotation1
Binding sitei187SubstrateUniRule annotation1
Binding sitei202SubstrateUniRule annotation1
Binding sitei209SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 15NADPUniRule annotation7
Nucleotide bindingi105 – 108NADPUniRule annotation4
Nucleotide bindingi163 – 166NADPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotation, Multifunctional enzymeUniRule annotation, OxidoreductaseUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00128;UER00191

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-L-fucose synthaseUniRule annotation (EC:1.1.1.271UniRule annotation)
Alternative name(s):
GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductaseUniRule annotation
Gene namesi
Name:fclUniRule annotation
ORF Names:AC784_00745Imported
OrganismiHelicobacter pylori (Campylobacter pylori)Imported
Taxonomic identifieri210 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000037093 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 238EpimeraseInterPro annotationAdd BLAST234

Sequence similaritiesi

Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.UniRule annotation

Family and domain databases

CDDicd05239 GDP_FS_SDR_e, 1 hit
HAMAPiMF_00956 GDP_fucose_synth, 1 hit
InterProiView protein in InterPro
IPR001509 Epimerase_deHydtase
IPR028614 GDP_fucose/colitose_synth
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF01370 Epimerase, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0K9MX26-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNEIVLITGA YGMVGQNTAL YFKKNRPDVA LLTPKKSELY LLDKDNVQAY
60 70 80 90 100
LKEYKPTGII HCAGRVGGIV ANMNDLSTYM VENLLMGLYL FSSSLDLGVK
110 120 130 140 150
KAINLASSCA YPKFAPNPLK ESDLLNGSLE PTNEGYALAK LSVMKYCEYV
160 170 180 190 200
SAEKGVFYKT LVPCNLYGEF DKFEEKIAHM IPGLISRMHT AKLKNEKEFT
210 220 230 240 250
MWGDGTARRE YLNAKDLARF ISLAYDNIAS IPSVMNVGSG VDYSIEEYYE
260 270 280 290 300
KVAQVLDYKG AFVKDLSKPV GMQQKLMDIS KQKALKWELE IPLEQGIKEA
310
YEYYLKLLEV
Length:310
Mass (Da):34,874
Last modified:November 11, 2015 - v1
Checksum:iC41EC248183E0A2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LFBZ01000002 Genomic DNA Translation: KMZ48370.1
RefSeqiWP_050829466.1, NZ_LFBZ01000002.1

Genome annotation databases

EnsemblBacteriaiKMZ48370; KMZ48370; AC784_00745
PATRICifig|210.1946.peg.321

Similar proteinsi

Entry informationi

Entry nameiA0A0K9MX26_HELPX
AccessioniPrimary (citable) accession number: A0A0K9MX26
Entry historyiIntegrated into UniProtKB/TrEMBL: November 11, 2015
Last sequence update: November 11, 2015
Last modified: October 25, 2017
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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