Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Quinolinate synthase

Gene

AC784_04740

Organism
Helicobacter pylori (Campylobacter pylori)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.SAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.SAAS annotation

Cofactori

[4Fe-4S] clusterSAAS annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes quinolinate from iminoaspartate.SAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Quinolinate synthase (AK968_04145), Quinolinate synthase (ACM27_07100), Quinolinate synthase (BB404_07050), Quinolinate synthase A (nadA), Quinolinate synthase (BB423_05755), Quinolinate synthase (BB463_00520), Quinolinate synthase (BB398_07655), Quinolinate synthase (BV499_07240), Quinolinate synthase (BGL58_03270), Quinolinate synthase (BB461_05325), Quinolinate synthase A (nadA), Quinolinate synthase (BB415_07315), Quinolinate synthase (BB451_03970), Quinolinate synthase (CEP78_008860), Quinolinate synthase A (nadA), Quinolinate synthase (AM496_03720), Quinolinate synthase (AC783_03365), Quinolinate synthase (BB408_07620), Quinolinate synthase (BGL77_00455), Quinolinate synthase (BB413_07120), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (C2S26_01385), Quinolinate synthase (C2R59_06220), Quinolinate synthase (BXP09_07305), Quinolinate synthase (C2S30_03365), Quinolinate synthase A (nadA), Quinolinate synthase (C2R94_06780), Quinolinate synthase (C2R52_06985), Quinolinate synthase (C2R72_06525), Quinolinate synthase (C2S36_00290), Quinolinate synthase (C2S42_01505), Quinolinate synthase (C2R78_00565), Quinolinate synthase (C2R50_03475), Quinolinate synthase A (nadA), Quinolinate synthase (C2R90_05785), Quinolinate synthase (C2S49_05140), Quinolinate synthase (BB388_00285), Quinolinate synthase (EG63_06695), Quinolinate synthase (BB384_07435), Quinolinate synthase (C2R91_00315), Quinolinate synthase (BB411_06835), Quinolinate synthase (HPMKF10_0090), Quinolinate synthase (BB459_06300), Quinolinate synthase (HPF209_0046), Quinolinate synthase A (nadA), Quinolinate synthase (BGL76_00185), Quinolinate synthase (BB469_07440), Quinolinate synthase A (nadA), Quinolinate synthase (ACM24_00465), Quinolinate synthase (AV921_0207375), Quinolinate synthase (BB400_07225), Quinolinate synthase A (nadA), Quinolinate synthase (BB409_06655), Quinolinate synthase A (nadA), Quinolinate synthase (AA974_06160), Quinolinate synthase (AA971_06325), Quinolinate synthase A (nadA), Quinolinate synthase (HPF210_0043), Quinolinate synthase (BGL62_06235), Quinolinate synthase (BB428_03850), Quinolinate synthase (BGL64_00830), Quinolinate synthase A (nadA), Quinolinate synthase (AEY55_07010), Quinolinate synthase A (nadA), Quinolinate synthase (ACM28_02565), Quinolinate synthase (BB389_07500), Quinolinate synthase A (nadA), Quinolinate synthase (AA976_06880), Quinolinate synthase (AOD76_0201075), Quinolinate synthase (BB394_06350), Quinolinate synthase (AEY52_07200), Quinolinate synthase A (nadA), Quinolinate synthase (BHU51_02520), Quinolinate synthase (CGC32_07160), Quinolinate synthase (HPMKM6_0049), Quinolinate synthase (BZK20_00770), Quinolinate synthase (BB464_04980), Quinolinate synthase (BGL67_05465), Quinolinate synthase (BB425_05080), Quinolinate synthase (BB454_05770), Quinolinate synthase (HPY173_04020), Quinolinate synthase (ACM23_00975), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (HPF72_0043), Quinolinate synthase (BB468_06445), Quinolinate synthase (HPY499_01385), Quinolinate synthase A (nadA), Quinolinate synthase (BZK19_04595), Quinolinate synthase (HPMKM5_0045), Quinolinate synthase (BZK21_01005), Quinolinate synthase (BGL85_03255), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (HPF38_0050), Quinolinate synthase (HPF78_0049), Quinolinate synthase (BB433_07695), Quinolinate synthase (BGL78_02880), Quinolinate synthase (ACM26_07720), Quinolinate synthase (ACM37_05900), Quinolinate synthase (HPY228_06205), Quinolinate synthase (BGL87_02485), Quinolinate synthase A (nadA), Quinolinate synthase (HPF75_0049), Quinolinate synthase (C2S39_00525), Quinolinate synthase (C2S04_06770), Quinolinate synthase (C2R47_04725), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (C2R64_01230), Quinolinate synthase (C2S01_06240), Quinolinate synthase (HPF211_0044), Quinolinate synthase (C2S43_00550), Quinolinate synthase (C2R74_04685), Quinolinate synthase (C2R61_01325), Quinolinate synthase (C2R71_05645), Quinolinate synthase (C2R46_05590), Quinolinate synthase (C2S37_01960), Quinolinate synthase (C2R84_03715), Quinolinate synthase A (nadA), Quinolinate synthase (BGL82_01035), Quinolinate synthase (BB414_04340), Quinolinate synthase (BB436_03185), Quinolinate synthase (HPY1846_02420), Quinolinate synthase (BB392_04940), Quinolinate synthase (ACM32_02395), Quinolinate synthase (JM68_01315), Quinolinate synthase (C2R77_03215), Quinolinate synthase A (nadA), Quinolinate synthase (C2R86_04970), Quinolinate synthase (C2R68_06705), Quinolinate synthase A (nadA), Quinolinate synthase (BZK22_08035), Quinolinate synthase (BGL59_02580), Quinolinate synthase (BB395_04085), Quinolinate synthase (BB396_07710), Quinolinate synthase A (nadA), Quinolinate synthase (HPMKM1_0044), Quinolinate synthase (AA977_07105), Quinolinate synthase (BIZ48_04360), Quinolinate synthase (HPF63_0047), Quinolinate synthase (EE66_07745), Quinolinate synthase (BGL60_02890), Quinolinate synthase (BB401_04235), Quinolinate synthase (BGL71_06650), Quinolinate synthase (BGL75_01500), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (BGL55_07905), Quinolinate synthase (BB483_07670), Quinolinate synthase (BB430_03035), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (BB448_06675), Quinolinate synthase A (nadA), Quinolinate synthase (BB458_04130), Quinolinate synthase (BB399_06925), Quinolinate synthase (BB471_07420), Quinolinate synthase (AEY53_04695), Quinolinate synthase (HPMKF3_0043), Quinolinate synthase (BGL73_04555), Quinolinate synthase (BB407_01115), Quinolinate synthase A (nadA), Quinolinate synthase (AC786_05590), Quinolinate synthase (BB431_05820), Quinolinate synthase (HPY655_06365), Quinolinate synthase (nadA), Quinolinate synthase (BZK27_01705), Quinolinate synthase A (nadA), Quinolinate synthase (HPF17_0045), Quinolinate synthase (BB482_06490), Quinolinate synthase (BGL74_00845), Quinolinate synthase (HPF51_0044), Quinolinate synthase A (nadA), Quinolinate synthase (AB891_06965), Quinolinate synthase (BB447_01570), Quinolinate synthase (AA973_06160), Quinolinate synthase (ACM25_04670), Quinolinate synthase (BB386_06910), Quinolinate synthase (C2S45_05075), Quinolinate synthase (C2R85_06720), Quinolinate synthase (C2R96_00170), Quinolinate synthase (C2S08_04730), Quinolinate synthase (C2S44_00045), Quinolinate synthase A (nadA), Quinolinate synthase (C2R56_07420), Quinolinate synthase (C2R52_07065), Quinolinate synthase A (nadA), Quinolinate synthase (C2R73_00155), Quinolinate synthase (C2R54_02845), Quinolinate synthase (C2R48_04895), Quinolinate synthase (C2R66_07335), Quinolinate synthase A (nadA), Quinolinate synthase (C2S29_03110), Quinolinate synthase A (nadA), Quinolinate synthase (C2R92_05855), Quinolinate synthase (C2R82_03550), Quinolinate synthase (C2R81_07605), Quinolinate synthase (AC784_04740), Quinolinate synthase A (nadA), Quinolinate synthase (C2R45_07955), Quinolinate synthase (C2R87_02090), Quinolinate synthase (C2R76_05535), Quinolinate synthase (C2R70_03895), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (C2R57_06195), Quinolinate synthase (C2S07_04950), Quinolinate synthase (HPF20_0047), Quinolinate synthase (BB475_02850), Quinolinate synthase A (nadA), Quinolinate synthase (ACM31_06075), Quinolinate synthase (ACM29_05840), Quinolinate synthase (BB403_04690), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (HPF94_0043), Quinolinate synthase (AC782_02175), Quinolinate synthase (BB397_07615), Quinolinate synthase (BB390_03560), Quinolinate synthase (HPF55_0045), Quinolinate synthase (AB991_05550), Quinolinate synthase (BGL81_03250), Quinolinate synthase (BGL83_04195), Quinolinate synthase (BZK18_04270), Quinolinate synthase (BZK26_07335), Quinolinate synthase (HPY1786_06525), Quinolinate synthase (BGL70_03090), Quinolinate synthase (AOD77_0202490), Quinolinate synthase (BB445_06880), Quinolinate synthase (BB449_05335), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (BB434_03360)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from iminoaspartate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseSAAS annotation
Biological processPyridine nucleotide biosynthesisSAAS annotation
Ligand4Fe-4SSAAS annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00253;UER00327

Names & Taxonomyi

Protein namesi
Recommended name:
Quinolinate synthaseSAAS annotation (EC:2.5.1.72SAAS annotation)
Gene namesi
ORF Names:AC784_04740Imported
OrganismiHelicobacter pylori (Campylobacter pylori)Imported
Taxonomic identifieri210 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000037093 Componenti: Unassembled WGS sequence

Family & Domainsi

Family and domain databases

InterProiView protein in InterPro
IPR003473 NadA
IPR036094 NadA_sf
PANTHERiPTHR30573 PTHR30573, 1 hit
PfamiView protein in Pfam
PF02445 NadA, 1 hit
SUPFAMiSSF142754 SSF142754, 1 hit
TIGRFAMsiTIGR00550 nadA, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0K9MST9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTDNDLKTS IVELLHDLDA LLVAHFYQKD EIVELAHYTG DSLELAKIAS
60 70 80 90 100
QSDKNLIVFC GVHFMGESVK ALAFNKQVIM PKLSCCSMAR MIDSHYYDKS
110 120 130 140 150
IHLLKEYGVK EFYPITYINS NAEVKAKVAK DDGVVCTSRN ASKIFNHALK
160 170 180 190 200
QNKKIFFLPD KCLGENLALE NGLKSAVLGV NSPEEIKNAD VVCYNGFCSV
210 220 230 240 250
HQLFKLEDIE FYRQKYPDIL IAVHPECEPI VVSNADFSGS TSQIIEFVES
260 270 280 290 300
LSPHQKVAIG TESNLVNRLK AKRNHQNTFI LSSTLALCPT MNETTLKDLF
310 320 330
EVLKAYKNHR AYNAIELKDE VARWAKLALT KMMELS
Length:336
Mass (Da):37,831
Last modified:November 11, 2015 - v1
Checksum:i3CCF89A0EFD2A3D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LFBZ01000009 Genomic DNA Translation: KMZ46885.1
RefSeqiWP_050830191.1, NZ_LFBZ01000009.1

Genome annotation databases

EnsemblBacteriaiKMZ46885; KMZ46885; AC784_04740
PATRICifig|210.1946.peg.862

Similar proteinsi

Entry informationi

Entry nameiA0A0K9MST9_HELPX
AccessioniPrimary (citable) accession number: A0A0K9MST9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 11, 2015
Last sequence update: November 11, 2015
Last modified: July 18, 2018
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again