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Protein

Quinolinate synthase

Gene

AC784_04740

Organism
Helicobacter pylori (Campylobacter pylori)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.SAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterSAAS annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes quinolinate from iminoaspartate.SAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (nadA), Quinolinate synthase (C2R48_04895), Quinolinate synthase (BB401_04235), Quinolinate synthase A (nadA), Quinolinate synthase (HPY655_06365), Quinolinate synthase A (nadA), Quinolinate synthase (nadA), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (BB468_06445), Quinolinate synthase (C2R64_01230), Quinolinate synthase A (nadA), Quinolinate synthase (ACM37_05900), Quinolinate synthase A (nadA), Quinolinate synthase (C2R84_03715), Quinolinate synthase A (nadA), Quinolinate synthase (BHU51_02520), Quinolinate synthase (AA976_06880), Quinolinate synthase A (nadA), Quinolinate synthase (BB447_01570), Quinolinate synthase (BGL60_02890), Quinolinate synthase (BGL67_05465), Quinolinate synthase (C2R46_05590), Quinolinate synthase A (nadA), Quinolinate synthase (HPF51_0044), Quinolinate synthase (BGL73_04555), Quinolinate synthase (BZK20_00770), Quinolinate synthase (nadA), Quinolinate synthase (HPF20_0047), Quinolinate synthase (HPF55_0045), Quinolinate synthase (AA974_06160), Quinolinate synthase (BB475_02850), Quinolinate synthase (JM68_01315), Quinolinate synthase (C2S08_04730), Quinolinate synthase (C2S01_06240), Quinolinate synthase A (nadA), Quinolinate synthase (ACM31_06075), Quinolinate synthase (C2S45_05075), Quinolinate synthase (C2S36_00290), Quinolinate synthase (C2S30_03365), Quinolinate synthase (ACM24_00465), Quinolinate synthase (C2R59_06220), Quinolinate synthase (C2R52_07065), Quinolinate synthase (BB389_07500), Quinolinate synthase (BB399_06925), Quinolinate synthase (BB431_05820), Quinolinate synthase (BGL78_02880), Quinolinate synthase (AC786_05590), Quinolinate synthase (BGL77_00455), Quinolinate synthase (C2S37_01960), Quinolinate synthase (BB408_07620), Quinolinate synthase A (nadA), Quinolinate synthase (BGL74_00845), Quinolinate synthase (C2R56_07420), Quinolinate synthase (BB413_07120), Quinolinate synthase (BB451_03970), Quinolinate synthase (BB386_06910), Quinolinate synthase (AM496_03720), Quinolinate synthase A (nadA), Quinolinate synthase (BB433_07695), Quinolinate synthase (C2R91_00315), Quinolinate synthase (HPF38_0050), Quinolinate synthase A (nadA), Quinolinate synthase (HPY228_06205), Quinolinate synthase (CEP78_008860), Quinolinate synthase (C2R81_07605), Quinolinate synthase (C2R68_06705), Quinolinate synthase (C2R86_04970), Quinolinate synthase (AEY53_04695), Quinolinate synthase (BB482_06490), Quinolinate synthase (BGL58_03270), Quinolinate synthase (AB991_05550), Quinolinate synthase (HPMKM6_0049), Quinolinate synthase (AC782_02175), Quinolinate synthase (C2R70_03895), Quinolinate synthase (C2R76_05535), Quinolinate synthase (BB415_07315), Quinolinate synthase (HPY1786_06525), Quinolinate synthase (HPMKM5_0045), Quinolinate synthase (AOD77_0202490), Quinolinate synthase (BZK18_04270), Quinolinate synthase A (nadA), Quinolinate synthase (BZK19_04595), Quinolinate synthase (BGL62_06235), Quinolinate synthase (C2R73_00155), Quinolinate synthase A (nadA), Quinolinate synthase (HPF211_0044), Quinolinate synthase (C2R54_02845), Quinolinate synthase (AV921_0207375), Quinolinate synthase (C2R50_03475), Quinolinate synthase (CGC32_07160), Quinolinate synthase (BB403_04690), Quinolinate synthase (BB459_06300), Quinolinate synthase A (nadA), Quinolinate synthase (HPF72_0043), Quinolinate synthase (BZK27_01705), Quinolinate synthase (BB458_04130), Quinolinate synthase (BB448_06675), Quinolinate synthase (ACM26_07720), Quinolinate synthase (BGL83_04195), Quinolinate synthase (BGL75_01500), Quinolinate synthase (BB430_03035), Quinolinate synthase (BB407_01115), Quinolinate synthase (HPMKF3_0043), Quinolinate synthase (BB464_04980), Quinolinate synthase (C2S43_00550), Quinolinate synthase (BGL85_03255), Quinolinate synthase (BGL70_03090), Quinolinate synthase (BB394_06350), Quinolinate synthase (HPMKF10_0090), Quinolinate synthase A (nadA), Quinolinate synthase (C2R85_06720), Quinolinate synthase (C2R87_02090), Quinolinate synthase (AEY52_07200), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (AB891_06965), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (HPY173_04020), Quinolinate synthase A (nadA), Quinolinate synthase (C2S39_00525), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (BZK26_07335), Quinolinate synthase A (nadA), Quinolinate synthase (C2R66_07335), Quinolinate synthase (ACM25_04670), Quinolinate synthase (BB411_06835), Quinolinate synthase (ACM28_02565), Quinolinate synthase (BB425_05080), Quinolinate synthase (HPY499_01385), Quinolinate synthase A (nadA), Quinolinate synthase (BB483_07670), Quinolinate synthase (HPF75_0049), Quinolinate synthase (HPF17_0045), Quinolinate synthase A (nadA), Quinolinate synthase (BGL87_02485), Quinolinate synthase (C2R45_07955), Quinolinate synthase (AC783_03365), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (BGL55_07905), Quinolinate synthase (BB471_07420), Quinolinate synthase (C2R74_04685), Quinolinate synthase (C2R47_04725), Quinolinate synthase A (nadA), Quinolinate synthase (HPF78_0049), Quinolinate synthase (C2R77_03215), Quinolinate synthase (BIZ48_04360), Quinolinate synthase (C2R52_06985), Quinolinate synthase (BB392_04940), Quinolinate synthase (BGL59_02580), Quinolinate synthase (BB384_07435), Quinolinate synthase (BB436_03185), Quinolinate synthase (AA977_07105), Quinolinate synthase (BB388_00285), Quinolinate synthase (AC784_04740), Quinolinate synthase (C2R57_06195), Quinolinate synthase (BZK22_08035), Quinolinate synthase A (nadA), Quinolinate synthase (HPF210_0043), Quinolinate synthase (BB428_03850), Quinolinate synthase (C2R61_01325), Quinolinate synthase (C2S29_03110), Quinolinate synthase (BGL76_00185), Quinolinate synthase (AEY55_07010), Quinolinate synthase (C2S49_05140), Quinolinate synthase A (nadA), Quinolinate synthase (BB469_07440), Quinolinate synthase (BB390_03560), Quinolinate synthase A (nadA), Quinolinate synthase (C2R94_06780), Quinolinate synthase A (nadA), Quinolinate synthase (ACM32_02395), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (BB409_06655), Quinolinate synthase (C2S07_04950), Quinolinate synthase (C2R90_05785), Quinolinate synthase (BB414_04340), Quinolinate synthase (C2S26_01385), Quinolinate synthase (HPF63_0047), Quinolinate synthase (HPF209_0046), Quinolinate synthase (C2S42_01505), Quinolinate synthase (EG63_06695), Quinolinate synthase (EE66_07745), Quinolinate synthase A (nadA), Quinolinate synthase (BB395_04085), Quinolinate synthase (HPMKM1_0044), Quinolinate synthase (BGL82_01035), Quinolinate synthase (BB396_07710), Quinolinate synthase (HPY1846_02420), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (BXP09_07305), Quinolinate synthase A (nadA), Quinolinate synthase (BGL71_06650), Quinolinate synthase (C2R78_00565), Quinolinate synthase (BB397_07615), Quinolinate synthase A (nadA), Quinolinate synthase (BB400_07225), Quinolinate synthase (BGL64_00830), Quinolinate synthase (ACM29_05840), Quinolinate synthase (BB461_05325), Quinolinate synthase (BB454_05770), Quinolinate synthase (AA971_06325), Quinolinate synthase A (nadA), Quinolinate synthase (C2R92_05855), Quinolinate synthase (AOD76_0201075), Quinolinate synthase A (nadA), Quinolinate synthase (C2R72_06525), Quinolinate synthase (BGL81_03250), Quinolinate synthase (C2S44_00045), Quinolinate synthase (ACM23_00975), Quinolinate synthase (C2R82_03550), Quinolinate synthase (BB445_06880), Quinolinate synthase (BB449_05335), Quinolinate synthase A (nadA), Quinolinate synthase (HPF94_0043), Quinolinate synthase (BZK21_01005), Quinolinate synthase (AA973_06160), Quinolinate synthase (C2R96_00170), Quinolinate synthase (C2S04_06770), Quinolinate synthase (C2R71_05645), Quinolinate synthase (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (BB398_07655), Quinolinate synthase (ACM27_07100), Quinolinate synthase (BB404_07050), Quinolinate synthase (BB434_03360), Quinolinate synthase (BB463_00520), Quinolinate synthase (AK968_04145), Quinolinate synthase (BV499_07240), Quinolinate synthase A (nadA), Quinolinate synthase (BB423_05755), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from iminoaspartate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferaseSAAS annotation
Biological processPyridine nucleotide biosynthesisSAAS annotation
Ligand4Fe-4SSAAS annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00253;UER00327

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Quinolinate synthaseSAAS annotation (EC:2.5.1.72SAAS annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:AC784_04740Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHelicobacter pylori (Campylobacter pylori)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri210 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000037093 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003473 NadA
IPR036094 NadA_sf

The PANTHER Classification System

More...
PANTHERi
PTHR30573 PTHR30573, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02445 NadA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF142754 SSF142754, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00550 nadA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0K9MST9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTDNDLKTS IVELLHDLDA LLVAHFYQKD EIVELAHYTG DSLELAKIAS
60 70 80 90 100
QSDKNLIVFC GVHFMGESVK ALAFNKQVIM PKLSCCSMAR MIDSHYYDKS
110 120 130 140 150
IHLLKEYGVK EFYPITYINS NAEVKAKVAK DDGVVCTSRN ASKIFNHALK
160 170 180 190 200
QNKKIFFLPD KCLGENLALE NGLKSAVLGV NSPEEIKNAD VVCYNGFCSV
210 220 230 240 250
HQLFKLEDIE FYRQKYPDIL IAVHPECEPI VVSNADFSGS TSQIIEFVES
260 270 280 290 300
LSPHQKVAIG TESNLVNRLK AKRNHQNTFI LSSTLALCPT MNETTLKDLF
310 320 330
EVLKAYKNHR AYNAIELKDE VARWAKLALT KMMELS
Length:336
Mass (Da):37,831
Last modified:November 11, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3CCF89A0EFD2A3D9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LFBZ01000009 Genomic DNA Translation: KMZ46885.1

NCBI Reference Sequences

More...
RefSeqi
WP_050830191.1, NZ_LFBZ01000009.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
KMZ46885; KMZ46885; AC784_04740

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|210.1946.peg.862

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LFBZ01000009 Genomic DNA Translation: KMZ46885.1
RefSeqiWP_050830191.1, NZ_LFBZ01000009.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiKMZ46885; KMZ46885; AC784_04740
PATRICifig|210.1946.peg.862

Enzyme and pathway databases

UniPathwayi
UPA00253;UER00327

Family and domain databases

InterProiView protein in InterPro
IPR003473 NadA
IPR036094 NadA_sf
PANTHERiPTHR30573 PTHR30573, 1 hit
PfamiView protein in Pfam
PF02445 NadA, 1 hit
SUPFAMiSSF142754 SSF142754, 1 hit
TIGRFAMsiTIGR00550 nadA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0K9MST9_HELPX
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0K9MST9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 11, 2015
Last sequence update: November 11, 2015
Last modified: January 16, 2019
This is version 20 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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