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Entry version 31 (07 Oct 2020)
Sequence version 1 (11 Nov 2015)
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Protein

Class I unconventional myosin

Gene

AUD_0988

Organism
Aspergillus udagawae
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Plays an important role in polarized growth, spore germination, hyphal morphogenesis, and septal wall formation.ARBA annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi448 – 455ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotationARBA annotation, HydrolaseARBA annotation, Motor protein, MyosinPROSITE-ProRule annotationARBA annotation
LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Class I unconventional myosinARBA annotation
Alternative name(s):
Myosin-1ARBA annotation
Type I myosinARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:AUD_0988Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAspergillus udagawaeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri91492 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000036893 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini355 – 1034Myosin motorInterPro annotationAdd BLAST680
Domaini1092 – 1282TH1InterPro annotationAdd BLAST191
Domaini1380 – 1441SH3InterPro annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni74 – 96DisorderedSequence analysisAdd BLAST23
Regioni244 – 271DisorderedSequence analysisAdd BLAST28
Regioni304 – 345DisorderedSequence analysisAdd BLAST42
Regioni907 – 929Actin-bindingPROSITE-ProRule annotationAdd BLAST23
Regioni1266 – 1382DisorderedSequence analysisAdd BLAST117
Regioni1435 – 1554DisorderedSequence analysisAdd BLAST120

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili156 – 197Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi255 – 269PolarSequence analysisAdd BLAST15
Compositional biasi1277 – 1291PolarSequence analysisAdd BLAST15
Compositional biasi1327 – 1343Pro-richSequence analysisAdd BLAST17
Compositional biasi1366 – 1380Pro-richSequence analysisAdd BLAST15
Compositional biasi1442 – 1459Pro-richSequence analysisAdd BLAST18
Compositional biasi1505 – 1529PolarSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the OPA3 family.ARBA annotation
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysisARBA annotation, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
122881at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01378, MYSc_Myo1, 1 hit
cd11858, SH3_Myosin-I_fungi, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035535, Fungal_myosin-I_SH3
IPR036961, Kinesin_motor_dom_sf
IPR001609, Myosin_head_motor_dom
IPR010926, Myosin_TH1
IPR036072, MYSc_Myo1
IPR010754, OPA3-like
IPR027417, P-loop_NTPase
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00063, Myosin_head, 1 hit
PF06017, Myosin_TH1, 1 hit
PF07047, OPA3, 1 hit
PF00018, SH3_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193, MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00242, MYSc, 1 hit
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044, SSF50044, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51456, MYOSIN_MOTOR, 1 hit
PS50002, SH3, 1 hit
PS51757, TH1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0K8L232-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLTLKLSSL VIRTLSKPIA TYTSKNQIKA QAREHERFRR ICVSMAQGLH
60 70 80 90 100
RIDMRLRLGN LRDNAAAQRR AAAEAEVRKH KPTSPTVKTE AEAKAEEEAI
110 120 130 140 150
AKAKAAASEA AKPAPAPHIR PLSESKAIES GATFISETFL FLVAGGLIVY
160 170 180 190 200
ESWRSRRKET TRREDVEARL VELEQSEKAA RKALVALEKE VLHLKAKAGE
210 220 230 240 250
SVKSSVRILP REVWEVEEEE EAEELAEVDW WSRITSIFTF GQNTEQKPAE
260 270 280 290 300
VPKPVVQSNP SSPAISSVPV QFDQPPPKLV ANEAPSVRYL DAWAPYPGKS
310 320 330 340 350
AATIMGHSRR PAGGEKKSRG FGRSKAAADV GDGRQAGGKP QVKKATFEST
360 370 380 390 400
KKKEFGVSDL TLLSKISNEA INDNLKLRFE HDEIYTYIGH VLVSVNPFRD
410 420 430 440 450
LGIYTDNVLQ SYRGKNRLEV PPHVFAVAES AYYNMKSYKD NQCVIISGES
460 470 480 490 500
GAGKTEAAKR IMQYIASVSG GTDSSIQHTK EMVLATNPLL ESFGNAKTLR
510 520 530 540 550
NNNSSRFGKY LELEFNTNGE PVGANITNYL LEKSRVVGQI TNERNFHIFY
560 570 580 590 600
QFTKAAPQKY RDLFGIQQPQ SYLYTSRSKC YDVPGVDDSA EFRDTLNAMS
610 620 630 640 650
VIGMAESEQD DVFRMLSAIL WIGNVQFAED DSGNAVITDQ SVVDYVAYLL
660 670 680 690 700
EVDAAQVNKA FTIRVMETAR GGRRGSVYEV PLNTVQALAV RDALAKAIYF
710 720 730 740 750
NLFDWIVQRV NASLTARGEI ANSIGILDIY GFEIFEKNSF EQLCINYVNE
760 770 780 790 800
KLQQIFIQLT LKAEQDEYAR EQIQWTPIKY FDNKVVCSLI EDKRPPGVFA
810 820 830 840 850
ALNDACATAH ADSSAADNTF VGRLNFLSQN PNFENRQGQF IVKHYAGDVS
860 870 880 890 900
YAVAGMTDKN KDQLLKDLLN LVGTSGNQFV HSLFPEQVNQ DDKRRPPTAS
910 920 930 940 950
DKIKASANDL VATLMKAQPS YIRTIKPNDN KAPKEYNVGN VLHQIKYLGL
960 970 980 990 1000
QENVRIRRAG FAYRQTFDKF VERFYLLSPK TSYAGDYTWT GDAESGARQI
1010 1020 1030 1040 1050
LKDTSIPAEE YQMGITKVFV KTPETLFALE AMRDRYWHNM AIRIQRAWRN
1060 1070 1080 1090 1100
YLRYRTECAI RIQRFWRRTT GGLEFIKLRD QGHQLLNGRK ERRRMSLLGS
1110 1120 1130 1140 1150
RRFLGDYVGV GNKGGPGEMI RNGAAISGSE DILFSCRGEV LVSKFGRSSK
1160 1170 1180 1190 1200
PAPRILVLTN RHVYIIAQNL VNNQLAISSE RTIPIGAIKA ISASNLKDDW
1210 1220 1230 1240 1250
FSIVVGSPQE PDPLLNCVFK TEFFTHLNNT LRGQLNLKIA DHIEYNKKPG
1260 1270 1280 1290 1300
KLATVKVVKD PAVARDDSYK SGSIHTGPGE PANSVSKPTP RPKQVSARPV
1310 1320 1330 1340 1350
TNGKLLRPGG PGGRPSKLAA RPTPAAQPLP RATPQPAAPQ PAARAVPQPV
1360 1370 1380 1390 1400
AAVAASHART GSTASVRAPP PPPPAAAPAP KKPTAKVLYD FNSQQANELS
1410 1420 1430 1440 1450
IKAGEIVQIV SKEGNGWWLC MNMTTSAQGW TPEAYLEEQV APTPKPAPPP
1460 1470 1480 1490 1500
PPPTAPRSTP APATNGAAAA AKTKPAPPAP PAKRPNMAAR KAVPAPPPAP
1510 1520 1530 1540 1550
RDSAVSMNSH DSSGGSGRGT PNSMSNASLA GGLAEALRAR QHAMQGKQDD

DDDW
Length:1,554
Mass (Da):171,082
Last modified:November 11, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED00417F2D70369A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BBXM01000019 Genomic DNA Translation: GAO82028.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
GAO82028; GAO82028; AUD_0988

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BBXM01000019 Genomic DNA Translation: GAO82028.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblFungiiGAO82028; GAO82028; AUD_0988

Phylogenomic databases

OrthoDBi122881at2759

Family and domain databases

CDDicd01378, MYSc_Myo1, 1 hit
cd11858, SH3_Myosin-I_fungi, 1 hit
Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR035535, Fungal_myosin-I_SH3
IPR036961, Kinesin_motor_dom_sf
IPR001609, Myosin_head_motor_dom
IPR010926, Myosin_TH1
IPR036072, MYSc_Myo1
IPR010754, OPA3-like
IPR027417, P-loop_NTPase
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PfamiView protein in Pfam
PF00063, Myosin_head, 1 hit
PF06017, Myosin_TH1, 1 hit
PF07047, OPA3, 1 hit
PF00018, SH3_1, 1 hit
PRINTSiPR00193, MYOSINHEAVY
SMARTiView protein in SMART
SM00242, MYSc, 1 hit
SM00326, SH3, 1 hit
SUPFAMiSSF50044, SSF50044, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51456, MYOSIN_MOTOR, 1 hit
PS50002, SH3, 1 hit
PS51757, TH1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0K8L232_9EURO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0K8L232
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 11, 2015
Last sequence update: November 11, 2015
Last modified: October 7, 2020
This is version 31 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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