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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Tepidiphilus thermophilus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationImported
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00035;UER00042

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotationSAAS annotation (EC:5.3.1.24UniRule annotationSAAS annotation)
Short name:
PRAIUniRule annotation
Gene namesi
Name:trpFUniRule annotation
ORF Names:Ga0061068_101292Imported
OrganismiTepidiphilus thermophilusImported
Taxonomic identifieri876478 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaHydrogenophilaliaHydrogenophilalesHydrogenophilaceaeTepidiphilus
Proteomesi
  • UP000182108 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 214PRAIInterPro annotationAdd BLAST195

Sequence similaritiesi

Belongs to the TrpF family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00405 PRAI, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00135 PRAI, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001240 PRAI
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00697 PRAI, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0K6IQA3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQNPDPQNS NSAPPRRVRV KICGLTRSED VREACRLGAD ALGFVFYPPS
60 70 80 90 100
PRAVTIAQAE ALLAEVPPFV TTVGLFVNPT PDEVESVLER VPLDLLQFHG
110 120 130 140 150
DEPPELCRRF ARPYLKALRV RPGLDLLELA RCYPDAKGLL LDADSAVWGG
160 170 180 190 200
SGRAFDWNLI PPGLPCPVVL AGGLTPETVA EAIARVRPWA VDVSSGVEAA
210 220
KGIKCPQKMA AFFAAVTRGM R
Length:221
Mass (Da):23,853
Last modified:November 11, 2015 - v1
Checksum:i94550EB16D6CE838
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CYHH01000001 Genomic DNA Translation: CUB05269.1
RefSeqiWP_055422658.1, NZ_LIPU01000001.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CYHH01000001 Genomic DNA Translation: CUB05269.1
RefSeqiWP_055422658.1, NZ_LIPU01000001.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00035;UER00042

Family and domain databases

CDDicd00405 PRAI, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00135 PRAI, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001240 PRAI
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00697 PRAI, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0K6IQA3_9PROT
AccessioniPrimary (citable) accession number: A0A0K6IQA3
Entry historyiIntegrated into UniProtKB/TrEMBL: November 11, 2015
Last sequence update: November 11, 2015
Last modified: November 7, 2018
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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