Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Malate dehydrogenase

Gene

mdh

Organism
Bacteroides fragilis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33NADUniRule annotation1
Binding sitei83SubstrateUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Binding sitei96NADUniRule annotation1
Binding sitei121SubstrateUniRule annotation1
Binding sitei152SubstrateUniRule annotation1
Active sitei176Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 13NADUniRule annotation6
Nucleotide bindingi119 – 121NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported
Biological processTricarboxylic acid cycleUniRule annotationSAAS annotation
LigandNADUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotationImported
Synonyms:mdh_1Imported
ORF Names:AC239_07350Imported, CQW34_02076Imported, CQW35_02591Imported, HMPREF0101_04281Imported, HMPREF1018_04475Imported, HMPREF2533_00228Imported
OrganismiBacteroides fragilisImported
Taxonomic identifieri817 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000231977 Componenti: Unassembled WGS sequence
  • UP000231846 Componenti: Unassembled WGS sequence
  • UP000075608 Componenti: Unassembled WGS sequence
  • UP000005743 Componenti: Unassembled WGS sequence
  • UP000006425 Componenti: Unassembled WGS sequence
  • UP000094213 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 143Ldh_1_NInterPro annotationAdd BLAST141
Domaini148 – 303Ldh_1_CInterPro annotationAdd BLAST156

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

KOiK00024
OrthoDBiPOG091H02N6

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0K6BYL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKVTVVGAG NVGATCANVL AFNEVADEVV MLDVKEGVSE GKAMDMMQTA
60 70 80 90 100
QLLGFDTTIV GCTNDYAQTA NSDVVVITSG IPRKPGMTRE ELIGVNAGIV
110 120 130 140 150
KSVAENLLKY SPNAIIVVIS NPMDTMTYLA LKSLGLPKNR VIGMGGALDS
160 170 180 190 200
SRFKYFLSQA LGCNANEVEG MVIGGHGDTT MIPLARLATY KGQPVSTLLS
210 220 230 240 250
EEKLNEVVAS TMVGGATLTK LLGTSAWYAP GAAGAYVVES IIHNQKKMVP
260 270 280 290 300
CSVMLEGEYG ESDLCIGVPV ILGKNGIEKI VELELNADEK AKFAASAAAV
310
HKTNAALKEV GAL
Length:313
Mass (Da):32,676
Last modified:November 11, 2015 - v1
Checksum:iF3C4B9F01445DC14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG705214 Genomic DNA Translation: EEZ23949.1
ACWI01000039 Genomic DNA Translation: EGN01891.1
LTZK01000008 Genomic DNA Translation: KXU51055.1
LIDV01000041 Genomic DNA Translation: OCR44217.1
PDCT01000013 Genomic DNA Translation: PJY65388.1
PDCW01000012 Genomic DNA Translation: PJY74748.1
RefSeqiWP_005791692.1, NZ_PDCX01000014.1

Genome annotation databases

EnsemblBacteriaiCUA20316; CUA20316; MB0529_03712
EEZ23949; EEZ23949; HMPREF0101_04281
EGN01891; EGN01891; HMPREF1018_04475
KXU51055; KXU51055; HMPREF2533_00228
KEGGibfb:VU15_17890
PATRICifig|665938.3.peg.4715
fig|817.54.peg.3425

Similar proteinsi

Entry informationi

Entry nameiA0A0K6BYL6_BACFG
AccessioniPrimary (citable) accession number: A0A0K6BYL6
Secondary accession number(s): D1JWD0, F7LWI1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 11, 2015
Last sequence update: November 11, 2015
Last modified: June 20, 2018
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health