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Protein
Submitted name:

Myoblast growth factor receptor egl-15

Gene

egl-15

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinase, ReceptorSAAS annotationImported, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Myoblast growth factor receptor egl-15Imported
Gene namesi
Name:egl-15Imported
ORF Names:CELE_F58A3.2Imported, F58A3.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF58A3.2j ; CE50367 ; WBGene00001184 ; egl-15

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei474 – 497HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500549395520 – 992Sequence analysisAdd BLAST973

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

SMRiA0A0K3AWC2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 125Ig-likeInterPro annotationAdd BLAST93
Domaini235 – 331Ig-likeInterPro annotationAdd BLAST97
Domaini339 – 449Ig-likeInterPro annotationAdd BLAST111
Domaini588 – 879Protein kinaseInterPro annotationAdd BLAST292

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118923

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07679 I-set, 3 hits
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

A0A0K3AWC2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYFLASCLG VGLLSTVSCS LQGLTSHYRE NIPRFKHVAN ERYEVFLGDE
60 70 80 90 100
IKFDCQTAAS KISAFVEWYR NDKLLKNDQI DKDKIRKDNN RMMLHLKNID
110 120 130 140 150
VSDQGLWSCR VHNAYGQISR NFTVEVIDPL KLFDWLTEHR VFDISHLLPK
160 170 180 190 200
LLPPAEMRRV KSQLGGWEKM NNEQKIVRAR HILRLRQINH ALGTEFINAD
210 220 230 240 250
EKENKEDEEE DYSVSQPVAP DAGLTELNIT AEEPPYFKSN DNIVLFNETH
260 270 280 290 300
ALPAGRTLKL NCRAKGYPEP QIIWYKNGKM LKKSSARSGG YEFKFNRWSL
310 320 330 340 350
EVEDAVVADS GEFHCEALNK VGSAKKYFHV IIVNRMRRPP IIVPNILANQ
360 370 380 390 400
SVNINDTATF HCKVVSDLLP HIIWVRINKI NGSYSYYNNS AEEYMFNYTE
410 420 430 440 450
MDTFDKAHVH HVGDESTLTI FNVSLDDQGI YACLSGNSLG MSMANATLTV
460 470 480 490 500
NEFMAIHLLT GDEPKIDRWT TSDYIFTTIL LFLLLAATLF GILFMVCKQT
510 520 530 540 550
LHKKGFMDDT VGLVARKKRV VVSKRPMNED NENSDDEPSP YQIQIIETPI
560 570 580 590 600
TKKEAARKQR KRMNSENTVL SEYEVDSDPV WEVERSKLSL VHMLGEGAFG
610 620 630 640 650
EVWKATYKET ENNEIAVAVK KLKMSAHEKE LIDLVSEMET FKVIGEHENV
660 670 680 690 700
LRLIGCCTGA GPLYVVVELC KHGNLRDFLR AHRPKEEKAK KSSQELTDYL
710 720 730 740 750
EPRKASDKDD IELIPNLTQR HLVQFAWQVA QGMNFLASKK IIHRDLAARN
760 770 780 790 800
VLVGDGHVLK ISDFGLSRDV HCNDYYRKRG NGRLPIKWMA LEALDSNVYT
810 820 830 840 850
VESDVWSYGV LLWEIMTLGG TPYPTIAMPE LYANLKEGYR MEPPHLCPQE
860 870 880 890 900
VYHLMCSCWR EKLEERPSFK TIVDYLDWML TMTNETIEGS QEFNDQFFSE
910 920 930 940 950
RSTASGPVSP MESFQKKRKH RPLSAPVNLP SEVDQNPQHT ICDDYESNFS
960 970 980 990
VEPPNDPNHL YCNDNMLKNH IITPETSQRI PSNNNSMSKP EF
Length:992
Mass (Da):113,784
Last modified:November 11, 2015 - v1
Checksum:iB4F6B8F73FF247F3
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q10656EGL15_CAEEL
Myoblast growth factor receptor egl...
egl-15 F58A3.2
1,040Annotation score:
A0A0K3AYK2A0A0K3AYK2_CAEEL
Myoblast growth factor receptor egl...
egl-15 CELE_F58A3.2, F58A3.2
1,091Annotation score:
A0A0K3ASR7A0A0K3ASR7_CAEEL
Myoblast growth factor receptor egl...
egl-15 CELE_F58A3.2, F58A3.2
1,044Annotation score:
A0A0K3AYL0A0A0K3AYL0_CAEEL
Myoblast growth factor receptor egl...
egl-15 CELE_F58A3.2, F58A3.2
1,101Annotation score:
A0A0K3AVM0A0A0K3AVM0_CAEEL
Myoblast growth factor receptor egl...
egl-15 CELE_F58A3.2, F58A3.2
1,153Annotation score:
A0A0K3AWC6A0A0K3AWC6_CAEEL
Myoblast growth factor receptor egl...
egl-15 CELE_F58A3.2, F58A3.2
1,105Annotation score:
A0A0K3AVM4A0A0K3AVM4_CAEEL
Myoblast growth factor receptor egl...
egl-15 CELE_F58A3.2, F58A3.2
998Annotation score:
A0A0K3ASS4A0A0K3ASS4_CAEEL
Myoblast growth factor receptor egl...
egl-15 CELE_F58A3.2, F58A3.2
994Annotation score:
A0A0K3ATB0A0A0K3ATB0_CAEEL
Myoblast growth factor receptor egl...
egl-15 CELE_F58A3.2, F58A3.2
1,046Annotation score:
A0A0K3AYK6A0A0K3AYK6_CAEEL
Myoblast growth factor receptor egl...
egl-15 CELE_F58A3.2, F58A3.2
1,043Annotation score:
There is more potential isoformShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CTQ87069.1
RefSeqiNP_001300358.1, NM_001313429.1
UniGeneiCel.17140

Genome annotation databases

EnsemblMetazoaiF58A3.2j.1; F58A3.2j.1; WBGene00001184
F58A3.2j.2; F58A3.2j.2; WBGene00001184
F58A3.2j.3; F58A3.2j.3; WBGene00001184
F58A3.2j.4; F58A3.2j.4; WBGene00001184
GeneIDi181291

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CTQ87069.1
RefSeqiNP_001300358.1, NM_001313429.1
UniGeneiCel.17140

3D structure databases

SMRiA0A0K3AWC2
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF58A3.2j.1; F58A3.2j.1; WBGene00001184
F58A3.2j.2; F58A3.2j.2; WBGene00001184
F58A3.2j.3; F58A3.2j.3; WBGene00001184
F58A3.2j.4; F58A3.2j.4; WBGene00001184
GeneIDi181291

Organism-specific databases

CTDi181291
WormBaseiF58A3.2j ; CE50367 ; WBGene00001184 ; egl-15

Phylogenomic databases

GeneTreeiENSGT00760000118923

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07679 I-set, 3 hits
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0K3AWC2_CAEEL
AccessioniPrimary (citable) accession number: A0A0K3AWC2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 11, 2015
Last sequence update: November 11, 2015
Last modified: October 10, 2018
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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