Cellular tumor antigen p53

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: Ensembl
• chaperone binding Source: Ensembl
• copper ion binding Source: Ensembl
• core promoter sequence-specific DNA binding Source: Ensembl
• disordered domain specific binding Source: Ensembl
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
• histone acetyltransferase binding Source: Ensembl
• histone deacetylase binding Source: Ensembl
• histone deacetylase regulator activity Source: Ensembl
• identical protein binding Source: Ensembl
• MDM2/MDM4 family protein binding Source: Ensembl
• mRNA 3'-UTR binding Source: Ensembl
• p53 binding Source: Ensembl
• promoter-specific chromatin binding Source: Ensembl
• protease binding Source: Ensembl
• protein heterodimerization activity Source: Ensembl
• protein N-terminus binding Source: Ensembl
• protein phosphatase 2A binding Source: Ensembl
• protein self-association Source: Ensembl
• receptor tyrosine kinase binding Source: Ensembl
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
• RNA polymerase II transcription factor binding Source: Ensembl
• TFIID-class transcription factor complex binding Source: Ensembl
• ubiquitin protein ligase binding Source: Ensembl

GO - Biological processⁱ

• autophagy Source: Ensembl
• B cell lineage commitment Source: Ensembl
• bone marrow development Source: Ensembl
• cardiac septum morphogenesis Source: Ensembl
• cellular response to actinomycin D Source: Ensembl
• cellular response to drug Source: Ensembl
• cellular response to gamma radiation Source: Ensembl
• cellular response to glucose starvation Source: Ensembl
• cellular response to UV-C Source: Ensembl
• cerebellum development Source: Ensembl
• chromatin assembly Source: Ensembl
• circadian behavior Source: Ensembl
• determination of adult lifespan Source: Ensembl
• DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Ensembl
• DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: Ensembl
• DNA strand renaturation Source: Ensembl
• double-strand break repair Source: Ensembl
• embryonic organ development Source: Ensembl
• entrainment of circadian clock by photoperiod Source: Ensembl
• ER overload response Source: Ensembl
• gastrulation Source: Ensembl
• hematopoietic stem cell differentiation Source: Ensembl
• interferon-gamma-mediated signaling pathway Source: Ensembl
• intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
• intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: Ensembl
• intrinsic apoptotic signaling pathway in response to hypoxia Source: Ensembl
• in utero embryonic development Source: Ensembl
• mitochondrial DNA repair Source: Ensembl
• mitotic cell cycle arrest Source: Ensembl
• mRNA transcription Source: Ensembl
• multicellular organism growth Source: Ensembl
• necroptotic process Source: Ensembl
• negative regulation of apoptotic process Source: Ensembl
• negative regulation of cell growth Source: Ensembl
• negative regulation of DNA replication Source: Ensembl
• negative regulation of fibroblast proliferation Source: Ensembl
• negative regulation of glucose catabolic process to lactate via pyruvate Source: Ensembl
• negative regulation of mitophagy Source: Ensembl
• negative regulation of neuroblast proliferation Source: Ensembl
• negative regulation of pentose-phosphate shunt Source: Ensembl
• negative regulation of production of miRNAs involved in gene silencing by miRNA Source: Ensembl
• negative regulation of proteolysis Source: Ensembl
• negative regulation of reactive oxygen species metabolic process Source: Ensembl
• negative regulation of telomerase activity Source: Ensembl
• negative regulation of transcription by RNA polymerase II Source: Ensembl
• negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
• neuron apoptotic process Source: Ensembl
• nucleotide-excision repair Source: Ensembl
• oligodendrocyte apoptotic process Source: Ensembl
• oxidative stress-induced premature senescence Source: Ensembl
• positive regulation of cardiac muscle cell apoptotic process Source: Ensembl
• positive regulation of cell aging Source: Ensembl
• positive regulation of execution phase of apoptosis Source: Ensembl
• positive regulation of histone deacetylation Source: Ensembl
• positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
• positive regulation of mitochondrial membrane permeability Source: Ensembl
• positive regulation of neuron apoptotic process Source: Ensembl
• positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
• positive regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
• positive regulation of production of miRNAs involved in gene silencing by miRNA Source: Ensembl
• positive regulation of programmed necrotic cell death Source: Ensembl
• positive regulation of reactive oxygen species metabolic process Source: Ensembl
• positive regulation of release of cytochrome c from mitochondria Source: Ensembl
• positive regulation of RNA polymerase II transcription preinitiation complex assembly Source: Ensembl
• positive regulation of thymocyte apoptotic process Source: Ensembl
• positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Source: Ensembl
• positive regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Ensembl
• protein import into nucleus Source: Ensembl
• protein stabilization Source: Ensembl
• protein tetramerization Source: InterPro
• Ras protein signal transduction Source: Ensembl
• regulation of cellular senescence Source: Ensembl
• regulation of DNA damage response, signal transduction by p53 class mediator Source: Ensembl
• regulation of fibroblast apoptotic process Source: Ensembl
• regulation of intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
• regulation of mitochondrial membrane permeability involved in apoptotic process Source: Ensembl
• regulation of tissue remodeling Source: Ensembl
• regulation of transcription from RNA polymerase II promoter in response to DNA damage Source: Ensembl
• release of cytochrome c from mitochondria Source: Ensembl
• replicative senescence Source: Ensembl
• response to ischemia Source: Ensembl
• response to salt stress Source: Ensembl
• response to X-ray Source: Ensembl
• rRNA transcription Source: Ensembl
• somitogenesis Source: Ensembl
• T cell differentiation in thymus Source: Ensembl
• T cell lineage commitment Source: Ensembl
• T cell proliferation involved in immune response Source: Ensembl
• transforming growth factor beta receptor signaling pathway Source: Ensembl
• tumor necrosis factor-mediated signaling pathway Source: Ensembl
• viral process Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Keywords - PTMⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• chaperone binding Source: Ensembl
• disordered domain specific binding Source: Ensembl
• histone acetyltransferase binding Source: Ensembl
• histone deacetylase binding Source: Ensembl
• identical protein binding Source: Ensembl
• MDM2/MDM4 family protein binding Source: Ensembl
• p53 binding Source: Ensembl
• protease binding Source: Ensembl
• protein heterodimerization activity Source: Ensembl
• protein N-terminus binding Source: Ensembl
• protein phosphatase 2A binding Source: Ensembl
• protein self-association Source: Ensembl
• receptor tyrosine kinase binding Source: Ensembl
• RNA polymerase II transcription factor binding Source: Ensembl
• TFIID-class transcription factor complex binding Source: Ensembl
• ubiquitin protein ligase binding Source: Ensembl

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MEEQQSDLSI EPPLSQETFS DLWKLLPQNN VLSTPLSPNS MEDLLLSPED 
        60         70         80         90        100
VANWLDDPDE ALQVPAAAIT GDPVTETSAP VAPPPATPWP LSSSVPSQKT 
       110        120        130        140        150
YQGSYGFRLG FLHSGTAKSV TCTYSPPLNK LFCQLAKTCP VQLWVDSTPP 
       160        170        180        190        200
PGTRVRAMAI YKKSQHMTEV VKRCPHHERC SDSDGLAPPQ HLIRVEGNLR 
       210        220        230        240        250
AEYLDDKHTF RHSVVVPYEP PEVGSDCTTI HYNYMCNSSC MGGMNRRPIL 
       260        270        280        290        300
TIITLEDSSG NLLGRNSFEV RVCACPGRDR RTEEENFRKK GELCPELPPG 
       310        320        330        340        350
STKRALPTGT SSSPQPKKKP LDGEYFTLKI RGRERFEMFR ELNEALELKD 
       360        370        380        390 
TQAEKDSGES RAHSSYLKSK KGQSTSRHKK LMIKREGPDS D          

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ