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Entry version 27 (02 Dec 2020)
Sequence version 1 (11 Nov 2015)
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Protein

3C-like proteinase

Gene

IBVgp1

Organism
Infectious bronchitis virus
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.ARBA annotation
Nsp9 is a ssRNA-binding protein.ARBA annotation
The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. Activity of PL-PRO is dependent on zinc.ARBA annotation
The peptide p16 might be involved in the EGF signaling pathway.ARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, RNA-bindingARBA annotation, Thiol proteaseARBA annotation
Biological processActivation of host autophagy by virusARBA annotation, Host-virus interaction
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
3C-like proteinaseARBA annotation
Alternative name(s):
Growth factor-like peptideARBA annotation
M-PROARBA annotation
Non-structural protein 10ARBA annotation
Non-structural protein 2ARBA annotation
Non-structural protein 3ARBA annotation
Non-structural protein 4ARBA annotation
Non-structural protein 6ARBA annotation
Non-structural protein 7ARBA annotation
Non-structural protein 8ARBA annotation
Non-structural protein 9ARBA annotation
Papain-like proteinaseARBA annotation
Peptide HD2ARBA annotation
nsp5ARBA annotation
p10ARBA annotation
p16ARBA annotation
p195ARBA annotation
p24ARBA annotation
p33ARBA annotation
p34ARBA annotation
p41ARBA annotation
p87ARBA annotation
p9ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:IBVgp1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiInfectious bronchitis virusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri11120 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesNidoviralesCornidovirineaeCoronaviridaeOrthocoronavirinaeGammacoronavirusIgacovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000151562 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1721 – 1739HelicalSequence analysisAdd BLAST19
Transmembranei1745 – 1765HelicalSequence analysisAdd BLAST21
Transmembranei1846 – 1873HelicalSequence analysisAdd BLAST28
Transmembranei2283 – 2301HelicalSequence analysisAdd BLAST19
Transmembranei2560 – 2581HelicalSequence analysisAdd BLAST22
Transmembranei2588 – 2608HelicalSequence analysisAdd BLAST21
Transmembranei2614 – 2632HelicalSequence analysisAdd BLAST19
Transmembranei2644 – 2669HelicalSequence analysisAdd BLAST26
Transmembranei3099 – 3119HelicalSequence analysisAdd BLAST21
Transmembranei3125 – 3142HelicalSequence analysisAdd BLAST18
Transmembranei3154 – 3172HelicalSequence analysisAdd BLAST19
Transmembranei3192 – 3210HelicalSequence analysisAdd BLAST19
Transmembranei3222 – 3240HelicalSequence analysisAdd BLAST19
Transmembranei3260 – 3283HelicalSequence analysisAdd BLAST24
Transmembranei3295 – 3322HelicalSequence analysisAdd BLAST28

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasmARBA annotation, Host membraneARBA annotation, Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1005 – 1181MacroInterPro annotationAdd BLAST177
Domaini1238 – 1499Peptidase C16InterPro annotationAdd BLAST262
Domaini2782 – 3088Peptidase C30InterPro annotationAdd BLAST307

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni783 – 817DisorderedSequence analysisAdd BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the coronaviruses polyprotein 1ab family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation, Zinc-fingerARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.370, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.40.220.10, 1 hit
3.90.70.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043610, CoV_NSP6
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR036333, NSP10_sf_CoV
IPR040795, Nsp1a_N
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043503, PLpro_palm_finger_dom_CoV
IPR018995, RNA_synth_NSP10_CoV

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09401, CoV_NSP10, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF01661, Macro, 1 hit
PF17896, Nsp2a_N, 1 hit
PF05409, Peptidase_C30, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00506, A1pp, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF50494, SSF50494, 1 hit
SSF52949, SSF52949, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51124, PEPTIDASE_C16, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0K1RMV2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSLKQGVS PKLRDVILVS KDIPEQLCDA LFFYTSHNPK DYADAFAVRH
60 70 80 90 100
KFDRSLQTGK QFKFETVCGL FLLKGVDKIT PGVPAKVLKS TSKLADLEDI
110 120 130 140 150
FGVSPFARKY RHLLKTACQW SLTVETLDAR AQTLDEIFDP TEILWLQVAA
160 170 180 190 200
KIQVSAMAMR RLVGEVTAKV MEALGSNLSA LFQIVKQQIA RIFQKALAIF
210 220 230 240 250
ENVSELPQRI AALKMAFAKC AKSITVVVVE RTLIVKEFAG TCLASINGAV
260 270 280 290 300
AKFFEELPNG FMGSKIFTTL AFFKEAAVKI VENIPNAPRG TKGFEVVGNA
310 320 330 340 350
KGTQVVVRGM RNDLTLLDQK VEIPVESEGW SAILEGHLCY VFKSGDRFYA
360 370 380 390 400
APLSGNFALH DVHCCERVVC LSDGVTPEIN DGLILAAIYS SFSVSELMAA
410 420 430 440 450
LKKGEPFKFL GHKFVYAKDA AVSFTLAKAA TIADVLKLFQ SARAKVEDVW
460 470 480 490 500
SSFTEKSFEF WKLAYGKVRI LEDFVRPQLV RLKWSMGILA TVLGEGIWHL
510 520 530 540 550
VSQVIYKVGG LFTKVVDFCE KYWKGFCAQL KRPKLIVTET LCVLKGVAQH
560 570 580 590 600
CFQLLLDAIH SMYKSFKKCA LGRIHGDLLF WKGGVHKIIQ EGDEIWFDAI
610 620 630 640 650
DSIDVEDLGV VQEKSIDFEV CDNVTLPENQ PGHMVQIQNE DKNYMFFRFK
660 670 680 690 700
KDENIYYTPM SQLGVINVVC KAGGKTVTFG ETTVQEIPPP DVVPIKVSIE
710 720 730 740 750
CCGEHGTQFS RKPIKEPIEV ETDFTVEQLL SVIYEKMCDD LKLFPEAPEP
760 770 780 790 800
PPFEKVSLVE KQGKDLDCIK SCHWIYRDYE SDDDIEEEDA EECDTDSGDA
810 820 830 840 850
EECDTNSECE EEDEDTKGLA LIQDQPSYKY PLPLEEDYSV YNGCIVHKDA
860 870 880 890 900
LDVVNLPSGE ETFVVNDCFE GAVKPLPQKV IDVLGDWGEA VDAQEQLCQQ
910 920 930 940 950
ESTQAAFERS VEDSIGGCEA MAEQSVVDEH ELLLVVEENQ HGVVYTPADL
960 970 980 990 1000
EGVKETAEEV DEFILIADVS KEEVVPQGKG ESQVEQEPIQ VVKSQREKKA
1010 1020 1030 1040 1050
KKFRVKPATC EKPKFLEYKT CVGDLTVVIA KALDEFKEFC IVNAANEHMS
1060 1070 1080 1090 1100
HGGGVAKAIA DFFGPDFVEY CEDYVKKHGP QQRLVTPSFV KGIQCENNVV
1110 1120 1130 1140 1150
GLRHGDINSR QKLVAAYKNV LVDGVVNYAV PVLSLGIFGV DFKMSIDAMR
1160 1170 1180 1190 1200
EAFEGCTIRV LLFSLSQEHI DYFDVTCKQK TLYLTEDGVK YRSVVVKPGD
1210 1220 1230 1240 1250
SLSQFGQVFA KNKAVFTADD VEDKEILFVP TTDKTVLEYY PLDAQKYVIY
1260 1270 1280 1290 1300
LQTLAQKWNV QYRDNFLILE WRDGNCWISS AIVLLQAAKI RFKGFLSEAW
1310 1320 1330 1340 1350
AKLLGGDPTD FVAWCYASCN AKVGDFSDAN WLLANFAEHF DADYKNAFLK
1360 1370 1380 1390 1400
KRVSCNCGVK SYELRGLEAC IQPVRATNLL HFKTQYSNCP TSGASNTDEV
1410 1420 1430 1440 1450
FEASLPYLLL FATDGPATVD CDEDAVGTVV FVGSTNSVHC DTQAARQAFD
1460 1470 1480 1490 1500
NLAKDRKFGK KSPYKTAMYT RFAFKNENPL PVAKHSKGKS KSVKEDVSNL
1510 1520 1530 1540 1550
ATSSKASFDN LTDFEQWYTS NIYESLKVQE SPYNFDKYVS FKIKEDSKLQ
1560 1570 1580 1590 1600
KTLKVRCIKS VFDFRSKDGF IYKLSPDTDE NSKAPVYYPV LDSISLRAIW
1610 1620 1630 1640 1650
VEGSANFVVG HPNYYSKFLH IPTFWENAEN FVKMGDKIGG VSMGLWRAEH
1660 1670 1680 1690 1700
LNKPNLERIF NIAKKAIVGS SVVTTQCGKL FGKAATFVAD KVGDGVVRNI
1710 1720 1730 1740 1750
TDSIKGLCGF TRGHFERKMS LQFLKTLMFF LFYFLKASVK SVVSSYKIVL
1760 1770 1780 1790 1800
CKVVFVTLLI VWIVYTSNPV MFTGIRVLDF VFEGSLCGPY KDYGKDSFDV
1810 1820 1830 1840 1850
LRNCAGDFTC RVCLHDRDSL HLFKYAYSVE QIYKDAASGI NFNWNWLYLV
1860 1870 1880 1890 1900
FLILFVKPVA GFVIICYCVK YLVLSSTVLQ TGVGFLDWFV KTVFSHFNFM
1910 1920 1930 1940 1950
GAGFYFWLFY KIYVQVHHIL YCKDGTCGVC KRVARSTRQE VSVVVGGRQQ
1960 1970 1980 1990 2000
IVHVYTNSGY NFCKRHNWYC RNCDDYGHQN TFMSPEVAGE LSEKLKRHVK
2010 2020 2030 2040 2050
PTAYAYPVVD EACLVDDFVN LKYKAATPGK DNASSAVKCF SVTNFLKKAV
2060 2070 2080 2090 2100
FLKEALKCEQ ISNDGFIVCN TQSAHALEEA KNAAVYYAQY LCKPILILDQ
2110 2120 2130 2140 2150
ALYEQLIVEP VSKSVVDKVC SILSNIISVD TAALNYKAGT LRDALLSITK
2160 2170 2180 2190 2200
DEEAVDMAIF CHNHEVEYTG DGFTNVIPSY GIDIDKLTPR DRGFLINADA
2210 2220 2230 2240 2250
SIANLRVKNA PPVVWKFSEL IKLSDSCLKY LISATVKSGV RFFITKSGVK
2260 2270 2280 2290 2300
QVIACHTQKL LVEKKAGGVI SGTFKWFMSC FKWLLIFEIL FTACCLGYYY
2310 2320 2330 2340 2350
LEVNKSFVHP MYDVNSTLHF EGFQVIDNGV LRDIVPEDNC FSNKSVNFDA
2360 2370 2380 2390 2400
FWGKSYENNK NCPIVTVVID GHGTVAVGFP GFVSWVMDGV MFVHKTQTDR
2410 2420 2430 2440 2450
RPWYIPTWFN TDIVGYTQDS NITEDSFYTS IALFSARCLY LSASNTRQLY
2460 2470 2480 2490 2500
CFNRENDAPG ALPFGSIIPH RVYFQPKGVR LKVPQQILHT PYLVKLVSDS
2510 2520 2530 2540 2550
YCRGSVCEYT KPGYRVSLDP QWVLFNDEYT SKPGVFCGST VRELMFNMVS
2560 2570 2580 2590 2600
TFFTGVNPNI YMQLATMFLI LVVIVLIFAM VIKFQGVFKA YATIVFTIML
2610 2620 2630 2640 2650
VWVINAFVLC VHSYNSVLAV ILLVLYCYAS LVKSRNTGII MHCGLVTMVG
2660 2670 2680 2690 2700
LIVPTCLSCC FLGFILYMYT PLFFWCYGTT KNTRKLYDGN EFVGNYDLAA
2710 2720 2730 2740 2750
KSTFVIRGSE FVKLTNEIGD KFEAYLSAYA RLNYYSGTGS EQDYLQACRA
2760 2770 2780 2790 2800
WLAYALDQYR NSGVEIVYLP PRYSIGVSRL QTGFKKLVSP SSAVEKCIVS
2810 2820 2830 2840 2850
VSYRGNNLNG LWLGDTIYCP RHVLGKFSGD QWNDVLNLAN NHEFEVTTQH
2860 2870 2880 2890 2900
GVTLNVVSRR LEGAVLILQT AVANAETPKY KFVKANCGDS FTIACSYGGT
2910 2920 2930 2940 2950
VVGLYPVTMR SNGTIRASFL AGACGSVGFN IEKGVVNFFY MHHLELPNAL
2960 2970 2980 2990 3000
HTGTDLTGEF YGGLVDEEVA QRVPPDNLVT NNIVAWLYAA IISVKESSFS
3010 3020 3030 3040 3050
QPKWLESTTV SIEDYNKWAS DNGLTPFSTS TAITKLCAIS GIDVCKLLRT
3060 3070 3080 3090 3100
IMVESAQWGS EPILGQYNFE DEYTPESVFN QIGGVRLQSS FVSKATSWFW
3110 3120 3130 3140 3150
SRCVLACFLF VLCAIVLFTA VPLKFYVYAA VILLLAVFFI SFTVKHVMAY
3160 3170 3180 3190 3200
MDTFLLPTLI TVIIGVCAEV PFMYNTLISQ VVIFLSQWYD PVFFDTMVPW
3210 3220 3230 3240 3250
MLLPLVLYTA FKCVQGCYMN SFNTSLLMLY QFMKFGFGIY TSSNTLTAYT
3260 3270 3280 3290 3300
EGNWELFFEL VHTTVLANVS SNSLFGLFVF KCAKWMLYYC NATYLYNYVL
3310 3320 3330 3340 3350
LAVMVNCIGW LCTCYFGLYW WVNKVFGLSF GKYNFKVSVD QYRYMCLHKI
3360 3370 3380 3390 3400
YPPKTVWEVF TTNILIQGIG GDRVFPISTV QSKLSDVKCT TVVLMQLLTK
3410 3420 3430 3440 3450
LNVEANSKMH AYLVELHNKI LASDDVGECM DNLLGMLITL FCIDSTIDLG
3460 3470 3480 3490 3500
EYCDDILKRS TVLQSVTQEF SHIPSYAEYE RAKSIYEKVL ADSKNGGVTQ
3510 3520 3530 3540 3550
QELAAYRNAA NIAKSVFDRD LAVQKKLDSM AERAMTTMYK EARVTDRRAK
3560 3570 3580 3590 3600
LVSSLHALLF SMLKKIDSEK LNVLFDQANS GVVPLATVPI VCSNKLTLVI
3610 3620 3630 3640 3650
PDPETWVKCV EVMHVTYSTV VWNIDCVTDA DGTELHPTST GSGLTYCISG
3660 3670 3680 3690 3700
DNIAWPLKVN LTRNGHNKVD VALQNNELMP HGVKTKACVA GVDQAHCSVE
3710 3720 3730 3740 3750
SKCYYTSISG SSVVAAITSS NSNLKVASFL NEAGNQIYVD LDPPCKFGMK
3760 3770 3780 3790 3800
VGDKVEVVYL YLIKNTRSIV RGMVLGAISN VVVLQSKGHE TEEVDAVGIL
3810 3820 3830 3840 3850
SLCSFAVDPA DTYCKYVAAG NQPLGNCVKM LTVHNGSGFA ITSKPSPTPD
3860 3870 3880 3890 3900
QDSYGGVSVC LYCRAHIAHP GGAGNLDARC QFKGSFVQIP TTEKDPVGFC
3910 3920 3930 3940 3950
LRNKVCTVCQ CWIGYGCQCD LLRQPKPSVQ SVAVASDFDK NYLNRVRGGS
3960 3970 3980
AARLLPLAHG CGPMLYGEPL MFVIRNQPVC FKI
Length:3,983
Mass (Da):445,499
Last modified:November 11, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i113B9CBAC46BD323
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KR902510 Genomic RNA Translation: AKV63204.1

Keywords - Coding sequence diversityi

Ribosomal frameshiftingARBA annotation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KR902510 Genomic RNA Translation: AKV63204.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.370, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.40.220.10, 1 hit
3.90.70.90, 1 hit
InterProiView protein in InterPro
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043610, CoV_NSP6
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR036333, NSP10_sf_CoV
IPR040795, Nsp1a_N
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043503, PLpro_palm_finger_dom_CoV
IPR018995, RNA_synth_NSP10_CoV
PfamiView protein in Pfam
PF09401, CoV_NSP10, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF01661, Macro, 1 hit
PF17896, Nsp2a_N, 1 hit
PF05409, Peptidase_C30, 1 hit
SMARTiView protein in SMART
SM00506, A1pp, 1 hit
SUPFAMiSSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF50494, SSF50494, 1 hit
SSF52949, SSF52949, 1 hit
PROSITEiView protein in PROSITE
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51124, PEPTIDASE_C16, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0K1RMV2_9GAMC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0K1RMV2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 11, 2015
Last sequence update: November 11, 2015
Last modified: December 2, 2020
This is version 27 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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