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UniProtKB - A0A0K0PUW7 (A0A0K0PUW7_HUMAN)
Protein
Submitted name:
G-protein coupled receptor
Gene
FFAR3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotationARBA annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Submitted name: G-protein coupled receptorImported |
Gene namesi | Name:FFAR3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000185897 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 15 – 40 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 52 – 70 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 90 – 111 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 132 – 153 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 188 – 211 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 223 – 241 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000185897, Expressed in blood and 79 other tissues |
ExpressionAtlasi | A0A0K0PUW7, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 276 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 246 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 307 – 346 | DisorderedSequence analysisAdd BLAST | 40 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 309 – 329 | Basic and acidic residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
OMAi | HWLYFSV |
OrthoDBi | 1129026at2759 |
PhylomeDBi | A0A0K0PUW7 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR013312, GPR40-rel_orph |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01904, GPR40FAMILY |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A0K0PUW7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDTGPDQSYF SGNHWFVFSV YLLTFLVGLP LNLLALVVFV GKLQRRPVAV
60 70 80 90 100
DVLLLNLTAS DLLLLLFLPF RMVEAANGMH WPLPFILCPL SGFIFFTTIY
110 120 130 140 150
LTALFLAAVS IERFLSVAHP LWYKTRPRLG QAGLVSVACW LLASAHCSVV
160 170 180 190 200
YVIEFSGDIS HSQGTNGTCY LEFRKDQLAI LLPVRLEMAV VLFVVPLIIT
210 220 230 240 250
SYCYSRLVWI LGRGGSHRRQ RRVAGLLAAT LLNFLVCFGP YNVSHVVGYI
260 270 280 290 300
CGESPAWRIY VTLLSTLNSC VDPFVYYFSS SGFQADFHEL LRRLCGLWGQ
310 320 330 340
WQQESSMELK EQKGGEEQRA DRPAERKTSE HSQGCGTGGQ VACAES
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KP715433 Genomic DNA Translation: AKQ70926.1 |
RefSeqi | NP_005295.1, NM_005304.4 |
Genome annotation databases
GeneIDi | 2865 |
KEGGi | hsa:2865 |
MANE-Selecti | ENST00000327809.5; ENSP00000328230.3; NM_005304.5; NP_005295.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KP715433 Genomic DNA Translation: AKQ70926.1 |
RefSeqi | NP_005295.1, NM_005304.4 |
3D structure databases
SMRi | A0A0K0PUW7 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A0K0PUW7 |
Protein family/group databases
GPCRDBi | Search... |
Protocols and materials databases
Antibodypediai | 55509, 180 antibodies from 27 providers |
DNASUi | 2865 |
Genome annotation databases
GeneIDi | 2865 |
KEGGi | hsa:2865 |
MANE-Selecti | ENST00000327809.5; ENSP00000328230.3; NM_005304.5; NP_005295.1 |
Organism-specific databases
CTDi | 2865 |
VEuPathDBi | HostDB:ENSG00000185897 |
Phylogenomic databases
OMAi | HWLYFSV |
OrthoDBi | 1129026at2759 |
PhylomeDBi | A0A0K0PUW7 |
Miscellaneous databases
BioGRID-ORCSi | 2865, 8 hits in 961 CRISPR screens |
GenomeRNAii | 2865 |
Gene expression databases
Bgeei | ENSG00000185897, Expressed in blood and 79 other tissues |
ExpressionAtlasi | A0A0K0PUW7, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR013312, GPR40-rel_orph |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01904, GPR40FAMILY |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0K0PUW7_HUMAN | |
Accessioni | A0A0K0PUW7Primary (citable) accession number: A0A0K0PUW7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 11, 2015 |
Last sequence update: | November 11, 2015 | |
Last modified: | January 19, 2022 | |
This is version 32 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |