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Protein

L-lactate dehydrogenase

Gene

LDHAL6B

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase B chain (LDHB), L-lactate dehydrogenase C chain (LDHC), L-lactate dehydrogenase A chain (LDHA), L-lactate dehydrogenase (LDHA), L-lactate dehydrogenase (LDHA), L-lactate dehydrogenase (LDHA), L-lactate dehydrogenase, L-lactate dehydrogenase (LDHAL6B), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase (LDHB), L-lactate dehydrogenase, L-lactate dehydrogenase (LDHB), L-lactate dehydrogenase (LDHA), L-lactate dehydrogenase (LDHA), L-lactate dehydrogenase, L-lactate dehydrogenase (LDHA)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei155SubstrateUniRule annotation1
Binding sitei187SubstrateUniRule annotation1
Binding sitei218SubstrateUniRule annotation1
Active sitei242Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00554;UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:LDHAL6BImported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Subcellular locationi

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 209Ldh_1_NInterPro annotationAdd BLAST139
Domaini213 – 377Ldh_1_CInterPro annotationAdd BLAST165

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

KOiK00016

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0K0KW08-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWAMVVLRT SQRVGAKRVN LPCPAVAPSA RRPAGLPLGD AWPVAPASKM
60 70 80 90 100
STVRCELMKN FTSEEVVHSN KISIVGTGSV GMACAISILL KGLTDELALV
110 120 130 140 150
DVDESRLKGE TMDLQHGSPF VKMPNIVSSK DYLITANSNL VIITAGARQE
160 170 180 190 200
KGETRLNLVQ RNVTIFKLMI SSIVQYSPRC KLIVVSNPVD ILTYVAWKLS
210 220 230 240 250
EFPQNRIIGS GCNLDTARFR FLIGQRLGIH SESCHGWILG EHGDSSVPVW
260 270 280 290 300
SGVNIAGVPL KNLNLDIGTD KDPEQWNNVH KDVVASAYEI IKMKGYTSWA
310 320 330 340 350
IGLSVADLTE SILKNLRRVH PVSTRIKGLY GINEEVFLSV PCILGESGIT
360 370 380
DLIKVKLTPE EEAYLQKSAK TLWEIQKELK F
Length:381
Mass (Da):41,861
Last modified:November 11, 2015 - v1
Checksum:iB58FE29B580B9A01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KM361875 mRNA Translation: AIQ84930.1
RefSeqiNP_001302607.1, NM_001315678.1

Genome annotation databases

GeneIDi100153697
KEGGissc:100153697

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KM361875 mRNA Translation: AIQ84930.1
RefSeqiNP_001302607.1, NM_001315678.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100153697
KEGGissc:100153697

Phylogenomic databases

KOiK00016

Enzyme and pathway databases

UniPathwayi
UPA00554;UER00611

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0K0KW08_PIG
AccessioniPrimary (citable) accession number: A0A0K0KW08
Entry historyiIntegrated into UniProtKB/TrEMBL: November 11, 2015
Last sequence update: November 11, 2015
Last modified: May 23, 2018
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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