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Protein

T cell receptor beta variable 27

Gene

TRBV27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).4 Publications

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
T cell receptor beta variable 271 Publication
Gene namesi
Name:TRBV271 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000211752.3
HGNCiHGNC:12208 TRBV27
neXtProtiNX_A0A0K0K1C4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000211752

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_501451710922 – 114T cell receptor beta variable 27Sequence analysisAdd BLAST93

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 110PROSITE-ProRule annotation
Glycosylationi103N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiA0A0K0K1C4

Expressioni

Gene expression databases

BgeeiENSG00000211752 Expressed in 71 organ(s), highest expression level in leukocyte

Interactioni

Subunit structurei

Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octomeric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface.1 Publication

Structurei

3D structure databases

SMRiA0A0K0K1C4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – ›114Ig-likePROSITE-ProRule annotationAdd BLAST›93

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

GeneTreeiENSGT00890000139388
HOGENOMiHOG000168489
HOVERGENiHBG099362
OMAiRKEKRNF

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A0A0K0K1C4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPQLLGYVV LCLLGAGPLE AQVTQNPRYL ITVTGKKLTV TCSQNMNHEY
60 70 80 90 100
MSWYRQDPGL GLRQIYYSMN VEVTDKGDVP EGYKVSRKEK RNFPLILESP
110
SPNQTSLYFC ASSL
Length:114
Mass (Da):12,838
Last modified:October 5, 2016 - v3
Checksum:i94E59C5C67F519A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei114Imported1

Polymorphismi

There are several alleles. The sequence shown is that of IMGT allele TRBV27*01.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC244472 Genomic DNA No translation available.
UniGeneiHs.511522

Genome annotation databases

EnsembliENST00000390399; ENSP00000374922; ENSG00000211752
ENST00000633283; ENSP00000488274; ENSG00000282234
UCSCiuc033amu.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC244472 Genomic DNA No translation available.
UniGeneiHs.511522

3D structure databases

SMRiA0A0K0K1C4
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA0A0K0K1C4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000390399; ENSP00000374922; ENSG00000211752
ENST00000633283; ENSP00000488274; ENSG00000282234
UCSCiuc033amu.2 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000211752.3
GeneCardsiTRBV27
HGNCiHGNC:12208 TRBV27
neXtProtiNX_A0A0K0K1C4
OpenTargetsiENSG00000211752
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00890000139388
HOGENOMiHOG000168489
HOVERGENiHBG099362
OMAiRKEKRNF

Gene expression databases

BgeeiENSG00000211752 Expressed in 71 organ(s), highest expression level in leukocyte

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTVB27_HUMAN
AccessioniPrimary (citable) accession number: A0A0K0K1C4
Secondary accession number(s): A0A075B6N5, A0A0A6YYR2, A0A5B5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 18, 2018
Last sequence update: October 5, 2016
Last modified: November 7, 2018
This is version 26 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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