UniProtKB - A0A0K0K1A5 (TVB65_HUMAN)
T cell receptor beta variable 6-5
TRBV6-5
Functioni
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- cell surface receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | Receptor |
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
PathwayCommonsi | A0A0K0K1A5 |
Protein family/group databases
IMGT/GENE-DB | TRBV6-5 |
Names & Taxonomyi
Protein namesi | Recommended name: T cell receptor beta variable 6-51 Publication |
Gene namesi | Name:TRBV6-51 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000211721.2 |
HGNCi | HGNC:12230, TRBV6-5 |
neXtProti | NX_A0A0K0K1A5 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication
Plasma Membrane
- plasma membrane Source: GO_Central
- T cell receptor complex Source: UniProtKB-KW
Keywords - Cellular componenti
Cell membrane, Membrane, T cell receptorPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5011354908 | 22 – 114 | T cell receptor beta variable 6-5Sequence analysisAdd BLAST | 93 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 42 ↔ 110 | Combined sources4 Publications | ||
Glycosylationi | 84 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PeptideAtlasi | A0A0K0K1A5 |
PTM databases
GlyGeni | A0A0K0K1A5, 1 site |
Expressioni
Gene expression databases
Bgeei | ENSG00000211721, Expressed in granulocyte and 89 other tissues |
Interactioni
Subunit structurei
Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked (PubMed:26875526). The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octomeric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface (PubMed:20452950).
1 Publication1 PublicationMiscellaneous databases
RNActi | A0A0K0K1A5, protein |
Structurei
Secondary structure
3D structure databases
SMRi | A0A0K0K1A5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – ›114 | Ig-likePROSITE-ProRule annotationAdd BLAST | ›93 |
Keywords - Domaini
Immunoglobulin domain, SignalPhylogenomic databases
GeneTreei | ENSGT00940000154542 |
OMAi | HIGDQSA |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MSIGLLCCAA LSLLWAGPVN AGVTQTPKFQ VLKTGQSMTL QCAQDMNHEY
60 70 80 90 100
MSWYRQDPGM GLRLIHYSVG AGITDQGEVP NGYNVSRSTT EDFPLRLLSA
110
APSQTSVYFC ASSY
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 114 | 1 |
Polymorphismi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC244196 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000390368; ENSP00000374891; ENSG00000211721 ENST00000633072; ENSP00000488123; ENSG00000277110 |
UCSCi | uc064isk.1, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC244196 Genomic DNA No translation available. |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AO7 | X-ray | 2.60 | E | 20-114 | [»] | |
1BD2 | X-ray | 2.50 | E | 20-114 | [»] | |
2BNQ | X-ray | 1.70 | E | 22-114 | [»] | |
2BNR | X-ray | 1.90 | E | 22-114 | [»] | |
2BNU | X-ray | 1.40 | B | 22-114 | [»] | |
4WWK | X-ray | 3.10 | B | 19-113 | [»] | |
6JXR | electron microscopy | 3.70 | n | 23-112 | [»] | |
6Q3S | X-ray | 2.50 | E | 22-114 | [»] | |
SMRi | A0A0K0K1A5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein family/group databases
IMGT/GENE-DB | TRBV6-5 |
PTM databases
GlyGeni | A0A0K0K1A5, 1 site |
Polymorphism and mutation databases
BioMutai | TRBV6-5 |
Proteomic databases
PeptideAtlasi | A0A0K0K1A5 |
Genome annotation databases
Ensembli | ENST00000390368; ENSP00000374891; ENSG00000211721 ENST00000633072; ENSP00000488123; ENSG00000277110 |
UCSCi | uc064isk.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000211721.2 |
GeneCardsi | TRBV6-5 |
HGNCi | HGNC:12230, TRBV6-5 |
neXtProti | NX_A0A0K0K1A5 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154542 |
OMAi | HIGDQSA |
Enzyme and pathway databases
PathwayCommonsi | A0A0K0K1A5 |
Miscellaneous databases
ChiTaRSi | TRBV6-5, human |
PROi | PR:A0A0K0K1A5 |
RNActi | A0A0K0K1A5, protein |
Gene expression databases
Bgeei | ENSG00000211721, Expressed in granulocyte and 89 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TVB65_HUMAN | |
Accessioni | A0A0K0K1A5Primary (citable) accession number: A0A0K0K1A5 Secondary accession number(s): A0A075B6M0, A0A0A6YYR1, A0A585 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 25, 2018 |
Last sequence update: | October 5, 2016 | |
Last modified: | August 12, 2020 | |
This is version 44 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - PDB cross-references
Index of Protein Data Bank (PDB) cross-references