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Entry version 20 (26 Feb 2020)
Sequence version 1 (14 Oct 2015)
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Protein

Hexokinase

Gene

Bm4678

Organism
Brugia malayi (Filarial nematode worm)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Active against glucose, fructose, mannose, maltose and galactose.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by glucose-6-phosphate. Inhibited by N-acetylglucosamine, glucosamine, mannoheptulose and ADP.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.035 mM for glucose1 Publication
  2. KM=75 mM for fructose1 Publication
  3. KM=1.09 mM for ATP1 Publication

    pH dependencei

    Optimum pH is 8.4.1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: hexose metabolism

    This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.1 Publication
    View all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.

    Pathwayi: glycolysis

    This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.1 Publication
    Proteins known to be involved in the 4 steps of the subpathway in this organism are:
    1. Phosphotransferase (Bma-hxk-3), Phosphotransferase (Bma-hxk-2), Phosphotransferase (Bma-hxk-1.1), Phosphotransferase (Bma-hxk-1.2), Phosphotransferase (Bma-hxk-1.3), Phosphotransferase (bma-hxk-1.1), Phosphotransferase (Bma-hxk-1.2), Phosphotransferase (Bma-hxk-1.1), Phosphotransferase (bma-hxk-1.1), Bm7152, isoform d (Bm7152), Phosphotransferase (Bma-hxk-1.2), Phosphotransferase (Bma-hxk-1.1), Hexokinase (Bm4678), Phosphotransferase (Bm7152), Phosphotransferase (Bm3363), Phosphotransferase (bma-hxk-1.1), Phosphotransferase (bma-hxk-1.3)
    2. Glucose-6-phosphate isomerase (bma-gpi-1), Glucose-6-phosphate isomerase (Bma-gpi-1)
    3. ATP-dependent 6-phosphofructokinase (Bm7088), 6-phosphofructokinase (Bm7089), ATP-dependent 6-phosphofructokinase (Bm7088), ATP-dependent 6-phosphofructokinase (Bm1_31220), 6-phosphofructokinase (Bm7089), ATP-dependent 6-phosphofructokinase (Bm8557)
    4. Fructose-bisphosphate aldolase (bma-aldo-1), Fructose-bisphosphate aldolase (Bma-aldo-1), Fructose-bisphosphate aldolase (Bma-aldo-2), Fructose-bisphosphate aldolase (bma-aldo-2)
    This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei185Glucose-6-phosphateBy similarity1
    Binding sitei239Glucose-6-phosphateBy similarity1
    Binding sitei263ATPBy similarity1
    Binding sitei263Glucose-6-phosphateBy similarity1
    Binding sitei266SubstrateBy similarity1
    Binding sitei297SubstrateBy similarity1
    Binding sitei331SubstrateBy similarity1
    Binding sitei483Glucose-6-phosphateBy similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi116 – 121ATPBy similarity6
    Nucleotide bindingi336 – 337ATPBy similarity2
    Nucleotide bindingi373 – 377ATPBy similarity5
    Nucleotide bindingi448 – 452ATPBy similarity5

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionKinase, Transferase
    Biological processGlycolysis
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.7.1.1 997

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00109;UER00180
    UPA00242

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Hexokinase1 Publication (EC:2.7.1.11 Publication)
    Short name:
    BmHK1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    ORF Names:Bm4678Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBrugia malayi (Filarial nematode worm)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6279 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaSpirurinaSpiruromorphaFilarioideaOnchocercidaeBrugia
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000006672 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004371731 – 572HexokinaseCuratedAdd BLAST572

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    A0A0K0JFP3

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini49 – 492HexokinasePROSITE-ProRule annotationAdd BLAST444

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni105 – 237Hexokinase small subdomainPROSITE-ProRule annotationAdd BLAST133
    Regioni116 – 120Glucose-6-phosphate bindingBy similarity5
    Regioni185 – 186Substrate bindingBy similarity2
    Regioni202 – 203Substrate bindingBy similarity2
    Regioni238 – 481Hexokinase large subdomainPROSITE-ProRule annotationAdd BLAST244
    Regioni238 – 239Substrate bindingBy similarity2
    Regioni446 – 448Glucose-6-phosphate bindingBy similarity3

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi504 – 526Gln-richPROSITE-ProRule annotationAdd BLAST23

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the hexokinase family.PROSITE-ProRule annotation

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001312 Hexokinase
    IPR022673 Hexokinase_C
    IPR022672 Hexokinase_N

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR19443 PTHR19443, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00349 Hexokinase_1, 1 hit
    PF03727 Hexokinase_2, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51748 HEXOKINASE_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    A0A0K0JFP3-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MLGLLTITSV FRNWRNSLQR KEDYDECHMR GINNENEISG KSEKNFKLDE
    60 70 80 90 100
    PPISLETVMA EFKLSNETLR RMMAHMSRNM DKGLEGGPEN STISMLPSFV
    110 120 130 140 150
    PELPNGTEEG RFIAMDLGGT NLRVMLMDIK PGEELKTEQF NTRIPNWAMR
    160 170 180 190 200
    GTGEQLFDYI TKCLAEFLIE KGIENDGLPV GFTFSYPCDQ KSLRSATLLR
    210 220 230 240 250
    WTKGFETTGV VGEDVVELLE QSIARRGDIK VEVVALINDT VGTMVAAAHE
    260 270 280 290 300
    SGGECHIGVI IATGTNASYM EDTSKIKYGL SKAIAAYNYP EMIIDTEWGG
    310 320 330 340 350
    FGDRSEADYI LTQYDKIVDS RSEHPGVNTF DKLVGGKCMG EVVRVVLEKL
    360 370 380 390 400
    TRARVLFNGK GSDALFQQDS FPTKYISEIL RDESGSYVHT RDILGELGID
    410 420 430 440 450
    HYSFSDMLLL REVCVVVSRR SANLGAAAIA CVLNRVRKQN MVVGIDGSTY
    460 470 480 490 500
    KYHPFFDFWV HDKLKELVDP GLKFKLLQTA DGSGKGAALI TAIVARLKKR
    510 520 530 540 550
    NLKQQQQQQQ QQQQHVTMVE QNVVEQIAET KGSREQFMNG NQKINLVTND
    560 570
    IPIYDSFNGD IENGVIHLST DH
    Length:572
    Mass (Da):64,043
    Last modified:October 14, 2015 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC2675B140514684B
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti68T → S in AAR13363 (PubMed:18499511).Curated1
    Sequence conflicti172G → S in AAR13363 (PubMed:18499511).Curated1
    Sequence conflicti504 – 509Missing in AAR13363 (PubMed:18499511).Curated6

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AY341346 mRNA Translation: AAR13363.1
    LN856840 Genomic DNA Translation: CRZ23240.1

    Genome annotation databases

    Ensembl metazoan genome annotation project

    More...
    EnsemblMetazoai
    Bm4678; Bm4678; WBGene00224939

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY341346 mRNA Translation: AAR13363.1
    LN856840 Genomic DNA Translation: CRZ23240.1

    3D structure databases

    SMRiA0A0K0JFP3
    ModBaseiSearch...

    Genome annotation databases

    EnsemblMetazoaiBm4678; Bm4678; WBGene00224939

    Enzyme and pathway databases

    UniPathwayiUPA00109;UER00180
    UPA00242
    BRENDAi2.7.1.1 997

    Family and domain databases

    InterProiView protein in InterPro
    IPR001312 Hexokinase
    IPR022673 Hexokinase_C
    IPR022672 Hexokinase_N
    PANTHERiPTHR19443 PTHR19443, 1 hit
    PfamiView protein in Pfam
    PF00349 Hexokinase_1, 1 hit
    PF03727 Hexokinase_2, 1 hit
    PROSITEiView protein in PROSITE
    PS51748 HEXOKINASE_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHXK_BRUMA
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0K0JFP3
    Secondary accession number(s): Q56VN6
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 7, 2016
    Last sequence update: October 14, 2015
    Last modified: February 26, 2020
    This is version 20 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
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