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Protein

5-demethoxyubiquinone hydroxylase, mitochondrial

Gene
N/A
Organism
Strongyloides venezuelensis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.UniRule annotation

Cofactori

Fe cationUniRule annotationNote: Binds 2 iron ions per subunit.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi39Iron 1UniRule annotation1
Metal bindingi69Iron 1UniRule annotation1
Metal bindingi69Iron 2UniRule annotation1
Metal bindingi72Iron 1UniRule annotation1
Metal bindingi121Iron 2UniRule annotation1
Metal bindingi157Iron 1UniRule annotation1
Metal bindingi157Iron 2UniRule annotation1
Metal bindingi160Iron 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenaseUniRule annotation, Oxidoreductase
Biological processUbiquinone biosynthesisUniRule annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
5-demethoxyubiquinone hydroxylase, mitochondrialUniRule annotation (EC:1.14.13.-UniRule annotation)
Short name:
DMQ hydroxylaseUniRule annotation
Alternative name(s):
Ubiquinone biosynthesis monooxygenase COQ7UniRule annotation
OrganismiStrongyloides venezuelensisImported
Taxonomic identifieri75913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaTylenchidaPanagrolaimomorphaStrongyloidoideaStrongyloididaeStrongyloides
Proteomesi
  • UP000035680 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the COQ7 family.UniRule annotation

Family and domain databases

CDDicd01042 DMQH, 1 hit
HAMAPiMF_01658 COQ7, 1 hit
InterProiView protein in InterPro
IPR009078 Ferritin-like_SF
IPR011566 Ubq_synth_Coq7
PANTHERiPTHR11237 PTHR11237, 1 hit
PfamiView protein in Pfam
PF03232 COQ7, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0K0F6Y4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSTDSLIPK KTAFERTPLS DEERKKLIQK ILRVDHMGEL AADRIYAGQL
60 70 80 90 100
SILKGSSVSS VIQHMWKDEK HHLDTFERLI EKKNMNSTVL APILSVVAFG
110 120 130 140 150
LGAGTAMISK EAAMACTIAV EELIVKHYND QIKELVADDP VVHADLLKTI
160 170 180 190
SKFRDEELEH HDTGIKYDGL KTPGYDILKG IVQNGCKAAI WVSEKI
Length:196
Mass (Da):21,850
Last modified:October 14, 2015 - v1
Checksum:i10A7356AF5CFB187
GO

Genome annotation databases

WBParaSiteiSVE_0458000.1; SVE_0458000.1; SVE_0458000

Similar proteinsi

Entry informationi

Entry nameiA0A0K0F6Y4_9BILA
AccessioniPrimary (citable) accession number: A0A0K0F6Y4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2015
Last sequence update: October 14, 2015
Last modified: March 28, 2018
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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