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Entry version 29 (31 Jul 2019)
Sequence version 1 (14 Oct 2015)
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Protein
Submitted name:

Receptor-type tyrosine-protein phosphatase zeta

Gene

Ptprz1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Receptor-type tyrosine-protein phosphatase zetaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ptprz1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:97816 Ptprz1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500532635623 – 1612Sequence analysisAdd BLAST1590

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000068748 Expressed in 249 organ(s), highest expression level in vestibular membrane of cochlear duct

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0J9YVD2 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A0J9YVD2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 300Alpha-carbonic anhydraseInterPro annotationAdd BLAST265
Domaini314 – 413Fibronectin type-IIIInterPro annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni428 – 511DisorderedSequence analysisAdd BLAST84
Regioni587 – 617DisorderedSequence analysisAdd BLAST31
Regioni631 – 680DisorderedSequence analysisAdd BLAST50
Regioni693 – 714DisorderedSequence analysisAdd BLAST22
Regioni1213 – 1239DisorderedSequence analysisAdd BLAST27
Regioni1407 – 1439DisorderedSequence analysisAdd BLAST33
Regioni1459 – 1612DisorderedSequence analysisAdd BLAST154

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi428 – 443PolyampholyteSequence analysisAdd BLAST16
Compositional biasi444 – 511PolarSequence analysisAdd BLAST68
Compositional biasi590 – 617PolarSequence analysisAdd BLAST28
Compositional biasi662 – 680PolarSequence analysisAdd BLAST19
Compositional biasi700 – 714PolarSequence analysisAdd BLAST15
Compositional biasi1218 – 1239PolarSequence analysisAdd BLAST22
Compositional biasi1466 – 1482PolarSequence analysisAdd BLAST17
Compositional biasi1541 – 1566PolarSequence analysisAdd BLAST26
Compositional biasi1587 – 1612PolarSequence analysisAdd BLAST26

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155529

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03122 alpha_CARP_receptor_like, 1 hit
cd00063 FN3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.10.200.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041887 Alpha_CARP_receptor-type
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00194 Carb_anhydrase, 1 hit
PF00041 fn3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01057 Carb_anhydrase, 1 hit
SM00060 FN3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 1 hit
SSF51069 SSF51069, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51144 ALPHA_CA_2, 1 hit
PS50853 FN3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A0J9YVD2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRILQSFLAC VQLLCLCRLD WAYGYYRQQR KLVEEIGWSY TGALNQKNWG
60 70 80 90 100
KKYPICNSPK QSPINIDEDL TQVNVNLKKL KFQGWEKASL ENTFIHNTGK
110 120 130 140 150
TVEINLTNDY YLSGGLSEKV FKASKITFHW GKCNVSSEGS EHSLEGQKFP
160 170 180 190 200
LEMQVYCFDA DRFSSFEEAV KGKGRLRALS ILFEVGVEEN LDYKAIIDGT
210 220 230 240 250
ESVSRFGKQA ALDPFVLQNL LPNSTDKYYI YNGSLTSPPC TDTVEWIVFK
260 270 280 290 300
DTVSISESQL AVFCEVLTMQ QSGYVMLMDY LQNNFREQQY KFSRQVFSSY
310 320 330 340 350
TGKEEIHEVV CSSEPENVQA DPENYTSLLV TWERPRVVYD AMIEKFAVLY
360 370 380 390 400
QPLAGNDQAK HEFLTDGYQD LGAILNNLLP NMSYVLQIVA VCSNGLYGKY
410 420 430 440 450
SDQLIVDMPT EDAELDLFPE LIGTEEIIKE EEYGKDNEED TGLNPGRDSV
460 470 480 490 500
TNQIRKKEPQ VSTTTHYNHM GTKYNEAKTN RSPTRGSEFS GKSDVPNTSP
510 520 530 540 550
NSTSQHVAEF ETERGISLPS QTGTNLPPHN VEGTSASLNS GSKTLFIFPQ
560 570 580 590 600
MNLSGTAESL NTVPITEYKE VSADVSEEEN FLTDFKLDTG ADDSSGSSPS
610 620 630 640 650
TSTVPFSSDN LSHGYITSSD MPEAITYDVL KPGSTRNAPE DSAPSGSEES
660 670 680 690 700
LKDPSLEGSV WFPGSTDLTT QSETGSGRES FLQVNSTDIQ IDESRETTES
710 720 730 740 750
FSPDATVSQD PSVTDMGMPH YSTFAYLPTE VTPQAFTPSS RPLDLAPTIN
760 770 780 790 800
ILHSQTTQPV YNGETPLQPS YSSEVFPLAT PLLLDNQTLN TTPAASSSDS
810 820 830 840 850
ALHATPVSPS VGVSFESILS SYDDAPLLPF SSASFSSEMF RHLHTVSQTL
860 870 880 890 900
PQVTSAAERD ELSLHASLLV ARGDLLLEPS LVQYSDVASH QATTRAASDT
910 920 930 940 950
LGFGSESAVF YKTSMVSQIE SPRSDVVMHA YSSGPEPSYT VEGSHHVPTV
960 970 980 990 1000
SYSSAMPLHG SVDVSDQGSL LINPSHISMP ESSFITPTAS LLQPPPALSG
1010 1020 1030 1040 1050
DGEWSGASSD SELLLPDADG LRTLNISSPV SVAEFTYTTS VFADGIKPLS
1060 1070 1080 1090 1100
KSEMMYGNET ELKMSSFSDM AYPSKSTVVP KMSDVVHKWS ESLKETSVSI
1110 1120 1130 1140 1150
SSMKSVFPES LVYPTTKGFE QGVSHVPEII FPVQPTHTAS QASGDTWLKP
1160 1170 1180 1190 1200
GLSANSEAAF SDTASREVVH PSTQPLLYEA ATPFNTEALL QPSFQASDVD
1210 1220 1230 1240 1250
TLLKTALPSV PSDPILAGTP QVEQSSSSVS HPMASESGSS ESMLHFTSVP
1260 1270 1280 1290 1300
ILDISPSKVH STPLQGLTVP HSSKKFSEQG LLKSKSPQQV LPSLFSNDEF
1310 1320 1330 1340 1350
FQSAHLDVSQ AYPPKGRHAF VTPVLSIDEP QNTLINKLVY SEDIFSSTEI
1360 1370 1380 1390 1400
SITDKVLTGL PTLASDVLSS TDHSVPLGSG PISLTMVSPN RDDSVTTAKL
1410 1420 1430 1440 1450
LLPSTATSKL TQSARSDADL VGGGEDGDDY DDDDYDDIDR GRFPVNKCMS
1460 1470 1480 1490 1500
CLPYRESREK VMNDSDTQES SLVDQSDPIS PLLFENTEEE NGGTGVTRVD
1510 1520 1530 1540 1550
KSPPPSMLPQ NHNDGKEDSD IQMGSAVLPH TPGSKAWAVL TSDEESGSGQ
1560 1570 1580 1590 1600
GTSDSLNDNE TSTDFSFPDV NEKDTDGVLE TDDTGIAPGS PRSSTPSVTS
1610
GHSGVSNSSE AG
Length:1,612
Mass (Da):174,989
Last modified:October 14, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C0C01B55390D249
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B9EKR1PTPRZ_MOUSE
Receptor-type tyrosine-protein phos...
Ptprz1
2,312Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B2RXS8B2RXS8_MOUSE
Ptprz1 protein
Ptprz1
1,463Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC133599 Genomic DNA No translation available.
AC134445 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000202579; ENSMUSP00000144605; ENSMUSG00000068748

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133599 Genomic DNA No translation available.
AC134445 Genomic DNA No translation available.

3D structure databases

SMRiA0A0J9YVD2
ModBaseiSearch...

Genome annotation databases

EnsembliENSMUST00000202579; ENSMUSP00000144605; ENSMUSG00000068748

Organism-specific databases

MGIiMGI:97816 Ptprz1

Phylogenomic databases

GeneTreeiENSGT00940000155529

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ptprz1 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000068748 Expressed in 249 organ(s), highest expression level in vestibular membrane of cochlear duct
ExpressionAtlasiA0A0J9YVD2 baseline and differential

Family and domain databases

CDDicd03122 alpha_CARP_receptor_like, 1 hit
cd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR041887 Alpha_CARP_receptor-type
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
PF00041 fn3, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SM00060 FN3, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
SSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS51144 ALPHA_CA_2, 1 hit
PS50853 FN3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0J9YVD2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0J9YVD2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2015
Last sequence update: October 14, 2015
Last modified: July 31, 2019
This is version 29 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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