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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

Dsim\GD12763

Organism
Drosophila simulans (Fruit fly)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Dsim\GD17417), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Dsim\GD12763), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Dsim\GD25325), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Dsim\GD25325), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Dsim\GD10425)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processElectron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
Name:Dsim\GD12763Imported
ORF Names:Dsimw501_GD12763Imported
OrganismiDrosophila simulans (Fruit fly)Imported
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0A0J9UJH7
SMRiA0A0J9UJH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 445FAD_binding_2InterPro annotationAdd BLAST398
Domaini500 – 651Succ_DH_flav_CInterPro annotationAdd BLAST152

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

KOiK00234

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0J9UJH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRLFVRRAG QHVTRSLFGP NASRLPQVTC VRDACCKDEY SLIDHKFDAI
60 70 80 90 100
VIGAGGAGMR AGFGLAEKGF QTAIISKLFP TRSHTVAAQG GVNAALSNMD
110 120 130 140 150
KDDWKYHFYD TVKGSDWLGD QNAIHYMCRE AEKAVCELDM YGMPFSRKPD
160 170 180 190 200
GKIYQRPFGG QTLDYGKGGV ARRACACADR TGHALIHTLY GQTLKHSDSC
210 220 230 240 250
HYFVDYFVLD LIMSQGACVG CLAWKLDDGT FHRFLAKNTV VAAGGCGRVY
260 270 280 290 300
FSTTAGHTCT GDGNAWVSRQ ELPLMDMEFV QFHPTGIYGA GCLITEGVRG
310 320 330 340 350
EGGFFLNCKG ERFMERYAPK AKDLASRDVV ARAMTMEVLA GNGCGPLKDH
360 370 380 390 400
VHLQLHHIDA KIIKQRLPGI MVTARIFAKV DVTKEPVPVL PTVHYNMGGI
410 420 430 440 450
PTDYKGRVVT IDENGKEQVV KGLYSCGETS CASVHGANRL GANSLLDLII
460 470 480 490 500
FGRVCALDIA ANSCPGDKPP QVEDKATEKS LDNFKRLRCA DGCIPTAALR
510 520 530 540 550
MELQRTMTKH AAVFREGKLL KEGLLKVAEL CEQFKDIKTT DRTMVWNSNL
560 570 580 590 600
VETLELQNML ANAVHIITAM ENRKESRGSH AREDFKTRVD ELDYGAPLAG
610 620 630 640 650
QKKKPFEEHW RKHTMTFALG NKGCASIKYR PVVDTTLDSS VAPIPPAPRT

Y
Length:651
Mass (Da):71,720
Last modified:October 14, 2015 - v1
Checksum:i79C04C83C6EE4FB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002912 Genomic DNA Translation: KMY99110.1
RefSeqiXP_016031517.1, XM_016169730.1

Genome annotation databases

EnsemblMetazoaiFBtr0363790; FBpp0327295; FBgn0184490
GeneIDi6737738
KEGGidsi:Dsimw501_GD12763

Similar proteinsi

Entry informationi

Entry nameiA0A0J9UJH7_DROSI
AccessioniPrimary (citable) accession number: A0A0J9UJH7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2015
Last sequence update: October 14, 2015
Last modified: June 20, 2018
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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