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Protein

Acetaldehyde dehydrogenase

Gene

ACT17_09300

Organism
Mycolicibacterium conceptionense
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei127Acyl-thioester intermediateUniRule annotation1
Binding sitei277NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 15NADUniRule annotation4
Nucleotide bindingi158 – 166NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processAromatic hydrocarbons catabolismUniRule annotationSAAS annotation
LigandNADUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenaseUniRule annotationSAAS annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]UniRule annotation
Gene namesi
ORF Names:ACT17_09300Imported
OrganismiMycolicibacterium conceptionenseImported
Taxonomic identifieri451644 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycolicibacterium
Proteomesi
  • UP000037594 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 119Semialdhyde_dhInterPro annotationAdd BLAST114

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0J8UDM3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEKASVAIV GSGNISTDLL YKLLRSEWLE PRWMIGIDPE SEGLARARKL
60 70 80 90 100
GLETSHEGVD WLLAQNEKPD LVFEATSAYV HRDAAPRYEE AGIRAIDLTP
110 120 130 140 150
AAVGPGVIPP ANLRAHLDAP NVNMVTCGGQ ATIPMVYAVS RVVDVPYAEI
160 170 180 190 200
VASVSSASAG PGTRANIDEF TKTTSAGVRD IGGAQKGKAI IILNPAEPPM
210 220 230 240 250
IMRDTIFCAI PEDADHAAIT QSIKDVVAEV QTYVPGYRLL NEPQFDEPSV
260 270 280 290 300
VNGGNHLVTV FVEVEGAGDY LPPYAGNLDI MTAAATKVGE EIAREMAGAR
310
ALSSSQGAQA
Length:310
Mass (Da):32,789
Last modified:October 14, 2015 - v1
Checksum:iFC691489D70460B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LFOD01000005 Genomic DNA Translation: KMV19052.1
RefSeqiWP_019346216.1, NZ_MBGF01000075.1

Genome annotation databases

PATRICifig|451644.5.peg.1910

Similar proteinsi

Entry informationi

Entry nameiA0A0J8UDM3_9MYCO
AccessioniPrimary (citable) accession number: A0A0J8UDM3
Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2015
Last sequence update: October 14, 2015
Last modified: July 18, 2018
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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