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Entry version 19 (11 Dec 2019)
Sequence version 1 (14 Oct 2015)
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Protein
Submitted name:

Reverse transcriptase

Gene

RF55_11367

Organism
Lasius niger (Black garden ant)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, RNA-directed DNA polymeraseImported, Transferase
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Reverse transcriptaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:RF55_11367Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLasius niger (Black garden ant)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri67767 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataFormicoideaFormicidaeFormicinaeLasiusLasius
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000036403 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini171 – 185CCHC-typeInterPro annotationAdd BLAST15
Domaini973 – 988CCHC-typeInterPro annotationAdd BLAST16
Domaini1424 – 1661Reverse transcriptaseInterPro annotationAdd BLAST238

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni350 – 491DisorderedSequence analysisAdd BLAST142
Regioni654 – 810DisorderedSequence analysisAdd BLAST157
Regioni1006 – 1025DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili595 – 615Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi370 – 399PolyampholyteSequence analysisAdd BLAST30
Compositional biasi469 – 483PolyampholyteSequence analysisAdd BLAST15
Compositional biasi664 – 688PolyampholyteSequence analysisAdd BLAST25
Compositional biasi709 – 723PolarSequence analysisAdd BLAST15
Compositional biasi731 – 749PolyampholyteSequence analysisAdd BLAST19
Compositional biasi770 – 789PolarSequence analysisAdd BLAST20

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
1233632at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.60.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR000477 RT_dom
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14529 Exo_endo_phos_2, 1 hit
PF00078 RVT_1, 1 hit
PF00098 zf-CCHC, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00343 ZnF_C2HC, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56219 SSF56219, 1 hit
SSF57756 SSF57756, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50878 RT_POL, 1 hit
PS50158 ZF_CCHC, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0J7N8R4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEARSKIDL KALGIVNSRI RQAINGGVLI QIPGKDRVKL ADDLANRMEE
60 70 80 90 100
VVKGKDVVIG RPSKLAELRI RGIDILVTPD CVTSAIALAG GCDVNCVQLG
110 120 130 140 150
QIRETASGFG TVWVRCPALA AKRVAGAGRV GLGWGFASVE LLPSRPLVCY
160 170 180 190 200
RCLLRGHTRS QCGSEIDRSD RCYRCGASGH RASSCASVPR CPLCADLGGP
210 220 230 240 250
ADHVWGGSEC CPAPESVCAP GVRSFKRPSE PSVRKVGSIS SPINRGSGEA
260 270 280 290 300
LKSIIIMADD KNRENLPQQG CLGAPAAGVA GTIVPGAPTS SSNEGLAGVL
310 320 330 340 350
EAGIPVNSAT IVDQVENPSP KKDLYTGLAL KTRSIDDILK DVYEGYKTVA
360 370 380 390 400
PSVGGPGDSS GQEGDTFFGD SPPAEHHRKE SAEMEVDSEA SRKKRKAEAS
410 420 430 440 450
LVVGSSSDEI ITPSISSRRR RRRNRLAVPS PNRGSVTDHI DLTADYETPH
460 470 480 490 500
GSDFTDAESV GRLGISRRQA SETRGDSRVK SSTPRKGKKP AIFGSKIDFK
510 520 530 540 550
PDLDSISSSQ LLGMSATNAG LIGLECVEVV EAVRARSSNF QGSWSGRMRV
560 570 580 590 600
KLNKINDVIR ALTQKAESSG DPALLEARVR ELSDELFATK KESGNERTEL
610 620 630 640 650
DKLKAENVVK DLKAELFSLK KGGITVGGST SIGASVLSEA PPSSVVNASS
660 670 680 690 700
VTFSESRAVG SSRDTPVTKK RTEEQTEHLV KEDIKGDSGR AAPVSMEWER
710 720 730 740 750
LPQRTPRPSK PRVVSNIQLV SPGGSGSAMK KRRISHRESV GEPKEGPEPG
760 770 780 790 800
KAAVRNTPSG KGGVGRSKGN LKSGTPNKRR GSKPTLNKGT ETGSKKKPRG
810 820 830 840 850
PVSPRTAAVS ITSRSEGFSY KDVLIKARSE ISLKDLKIES TRLRRAANGG
860 870 880 890 900
YLIEILDKDN AGKAQALREK FVGLDDTILP EEVVQLIASE GKCEEVDIKI
910 920 930 940 950
GRIQPMRNGL STIWARCPLS AAAVIAQRKR VRMGWTFVKV ELLKSRPMQC
960 970 980 990 1000
FKCWGFGHVR FSCTSTIDRS NLCFNCGGEG HSLRDCRSPS HCVVCESTGS
1010 1020 1030 1040 1050
KSDHKMGSAL CESNRKKPGK PVSRDPVKAA DMLEQHLIEL KIGLCVVSEP
1060 1070 1080 1090 1100
IRIPSTVFWF GTDFREFLEE LSGAVRALSG KIILCGDFNS KSSHWGSPIT
1110 1120 1130 1140 1150
NNRGDEVERW VAANDLRIAN VGNAPTCVRP QGSSIIDLTW VSLQAIGLIG
1160 1170 1180 1190 1200
DWSVREDVET LSDHSYITFS VGFSPARSTD SGGTGRRWNL SRMDMAAFDL
1210 1220 1230 1240 1250
SLVWACYDDS LGDDAFSAGE FARWLEDTVV EACDASTPRI GPKQPKRAAY
1260 1270 1280 1290 1300
WWSDSIAELR SSCVRARRRW TRGRRARRPL PVVEDLSMEY RARKKDLKRA
1310 1320 1330 1340 1350
IKAKSAAWRE LILTLNSDPW GLPYRLVLSR LRRSSPSLSE MLEPEVLDRL
1360 1370 1380 1390 1400
LDGLFPRGLE RDAPGDWGSF RWNEEWSISF AEVFRLLKGR AAKNTAPGPD
1410 1420 1430 1440 1450
GFKATLLRKV PNCMLDKIAA CYNKCMVEGV FPVPWKIANL VLIPKGDKGS
1460 1470 1480 1490 1500
ITGLPRFGFR KQRSTCDALS KVKAITSSAV GEGGVAIAVA LDIENAFNSL
1510 1520 1530 1540 1550
PWHSIRTALA ERRVPDYLRR ILDAYLSERY IEFRNTEGEL VRRSVEAGVP
1560 1570 1580 1590 1600
QGSVLGPLLW NIAYDSTLRV TKEPGCDVVC YADDTLIIAT ADDIGTAAIR
1610 1620 1630 1640 1650
VGIQVAMILS QIRRLGLRVS VQKTEAVVFH GRVGPDALPT ISVGDTRIEL
1660 1670 1680 1690 1700
KGSMKYLGVF IDSGWSFGDH FAYVTDKVSK VTRAFGRLMP NLRGPREDKR
1710 1720 1730 1740 1750
NLYSKVVQSV ILYGAPIWSD AFERSSGAQR SLRRLQRTLA IRVISAYRTT
1760 1770
SCDAALLLAK IPPPAHHRSV
Length:1,770
Mass (Da):192,401
Last modified:October 14, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i093F583CB7B9FA11
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LBMM01008226 Genomic DNA Translation: KMQ89040.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LBMM01008226 Genomic DNA Translation: KMQ89040.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Phylogenomic databases

OrthoDBi1233632at2759

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR000477 RT_dom
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF14529 Exo_endo_phos_2, 1 hit
PF00078 RVT_1, 1 hit
PF00098 zf-CCHC, 2 hits
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 4 hits
SUPFAMiSSF56219 SSF56219, 1 hit
SSF57756 SSF57756, 2 hits
PROSITEiView protein in PROSITE
PS50878 RT_POL, 1 hit
PS50158 ZF_CCHC, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0J7N8R4_LASNI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0J7N8R4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2015
Last sequence update: October 14, 2015
Last modified: December 11, 2019
This is version 19 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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