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Entry version 19 (12 Aug 2020)
Sequence version 1 (14 Oct 2015)
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Protein
Submitted name:

Reverse transcriptase

Gene

RF55_10119

Organism
Lasius niger (Black garden ant)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, RNA-directed DNA polymeraseImported, Transferase
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Reverse transcriptaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:RF55_10119Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLasius niger (Black garden ant)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri67767 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataFormicoideaFormicidaeFormicinaeLasiusLasius
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000036403 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini513 – 526CCHC-typeInterPro annotationAdd BLAST14
Domaini964 – 1256Reverse transcriptaseInterPro annotationAdd BLAST293

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni240 – 275DisorderedSequence analysisAdd BLAST36
Regioni291 – 356DisorderedSequence analysisAdd BLAST66

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili90 – 152Sequence analysisAdd BLAST63
Coiled coili220 – 240Sequence analysisAdd BLAST21
Coiled coili772 – 796Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi291 – 320PolyampholyteSequence analysisAdd BLAST30
Compositional biasi321 – 346PolarSequence analysisAdd BLAST26

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
695335at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.60.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR036691, Endo/exonu/phosph_ase_sf
IPR005135, Endo/exonuclease/phosphatase
IPR000477, RT_dom
IPR001878, Znf_CCHC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14529, Exo_endo_phos_2, 1 hit
PF00078, RVT_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00343, ZnF_C2HC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56219, SSF56219, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50878, RT_POL, 1 hit
PS50158, ZF_CCHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0J7KIS5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAWSSTEDG EDDETDFCPE ELKIMGASAI GAIGIDCLNI AEKERKNSPN
60 70 80 90 100
TNGAISGIIK RNIQRAADVI NTLTYKAEAK GDPTYLRIRN RELESQVEKM
110 120 130 140 150
QLEEALRNRE MEEMRTIVAD LKKEIYELKG RLDDAEEDAR KARESYRITK
160 170 180 190 200
RILKTGGGDI ACEVPLAVSG DLNLPVETID PQPMEVEEPS RKQPTGNFTA
210 220 230 240 250
LPSEAMTPVP VKENRNVNQI EEINLRIKDL VKVKRDLRRV AESENSESGS
260 270 280 290 300
VGFSRNSEKP LPQRIPRNKP RITSNIQVVP PKMDIKKVGF SKSMADEDKT
310 320 330 340 350
DSSHQEWTVA TRKREGGRRQ NIQEVTPSSS RGKKQPGATK DNAATTKSGA
360 370 380 390 400
AVRRPPKTAA VMITGNKENF SYADALKKAR GSISLDRLKI TKTKIRKAAN
410 420 430 440 450
GSLLIEVMGP GGAGKAAKLR DELHGILKDD AKVTRPVTKG QLRLIGLHDA
460 470 480 490 500
TSQDEVLEVI SNYGKCLKDD VKIGSIHPMR NGLFTWVQCP LSAAIIIANH
510 520 530 540 550
KKINLGVDFG MACFRCGNDG HIAKNCGSAP ACRVCRSDGR LFNHRLGSNL
560 570 580 590 600
PKNWAGLLLI SEPCTIAPSD NWLISQDGKS AIYYDMNFLN LRCRPAKQGN
610 620 630 640 650
RFVAIYCGPY LIVSTYISPN IGLHEYNAFL DELSGVLSSR VDKIIVAGDF
660 670 680 690 700
NAKASLWGSN VTNNRGLLVT RWAAERDLRV INAGDVPTCV RPQGSSIVDL
710 720 730 740 750
TWSSPDLLPL ISDWQVMKEM ESLSDHVCIR FDICTSRPRP STARPDNRRW
760 770 780 790 800
NLRKFDRGFF KAALIWGSPD PETENIQELE QLIQELDKLM EEACDASAPR
810 820 830 840 850
IGARRPRRKA YWWQESVANL RISCIHARRL WQRAKRRKRS PVVVNELGIR
860 870 880 890 900
YKSARKELRL EINRLKAKAW QELIESIDND PWGLPYKLML GKLRQSTPGL
910 920 930 940 950
SEVLEHDILS RLLDSLFPSN TRLDPLGDWS DFVWSDDWSV SLEEVTDALK
960 970 980 990 1000
KDPSSLSKAP GPNGFRLKGQ FPDTWKRANL VLIPKAGNPN IGAIDIPKAR
1010 1020 1030 1040 1050
PICLLDELGK TFERVLANRI HQWQVGNPDS DVSRFQFGFR KQKSTCDALL
1060 1070 1080 1090 1100
LVRKITSTAV KDGGFAFAIS LDIANAFNSI PWRIIRRALR ERNYPQYLRR
1110 1120 1130 1140 1150
ILDSYLTNRT IRYVDREGRH RCREMEAGVP QGSVLGPVLW NIAFDDVLRL
1160 1170 1180 1190 1200
AEDEDGSNII CYADDTLIIV TGKDLRRTQL KAGLLVARVI IFINRLGLKV
1210 1220 1230 1240 1250
AKEKTEAILF HNRGAVNLPT SILEKANKMV RALNKLMPNL RGPDERRRRL
1260 1270 1280 1290 1300
FANVVLSVIL YGAPVWGDVI VKKSCVLPAL YRLHRTVAQR VISAYRTVSS
1310 1320 1330 1340 1350
NAALLLARLP PIKLLATSRK NMYDRIKELR ETSNLDPISR KEIKESEFIN
1360 1370 1380 1390 1400
LCNAWRTILE KPNTPGEFTK MVIVPRLEIW LARDTINGMT FHLTQILTGH
1410
GCFSKYLHQI GKKADTM
Length:1,417
Mass (Da):159,360
Last modified:October 14, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i92C167FEE79EB6BF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LBMM01006977 Genomic DNA Translation: KMQ90149.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LBMM01006977 Genomic DNA Translation: KMQ90149.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Phylogenomic databases

OrthoDBi695335at2759

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR036691, Endo/exonu/phosph_ase_sf
IPR005135, Endo/exonuclease/phosphatase
IPR000477, RT_dom
IPR001878, Znf_CCHC
PfamiView protein in Pfam
PF14529, Exo_endo_phos_2, 1 hit
PF00078, RVT_1, 1 hit
SMARTiView protein in SMART
SM00343, ZnF_C2HC, 1 hit
SUPFAMiSSF56219, SSF56219, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS50878, RT_POL, 1 hit
PS50158, ZF_CCHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0J7KIS5_LASNI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0J7KIS5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2015
Last sequence update: October 14, 2015
Last modified: August 12, 2020
This is version 19 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported, Transposable elementARBA annotation
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