Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Methionine aminopeptidase 2

Gene

CIRG_08075

Organism
Coccidioides immitis RMSCC 2394
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).UniRule annotationSAAS annotation
Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei204SubstrateUniRule annotation1
Metal bindingi224Divalent metal cation 1UniRule annotation1
Metal bindingi235Divalent metal cation 1UniRule annotation1
Metal bindingi235Divalent metal cation 2; catalyticUniRule annotation1
Metal bindingi304Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation1
Binding sitei312SubstrateUniRule annotation1
Metal bindingi340Divalent metal cation 2; catalyticUniRule annotation1
Metal bindingi435Divalent metal cation 1UniRule annotation1
Metal bindingi435Divalent metal cation 2; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminopeptidaseUniRule annotationSAAS annotationImported, Hydrolase, Protease
LigandMetal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 2UniRule annotation (EC:3.4.11.18UniRule annotation)
Short name:
MAP 2UniRule annotation
Short name:
MetAP 2UniRule annotation
Alternative name(s):
Peptidase MUniRule annotation
Gene namesi
ORF Names:CIRG_08075Imported
OrganismiCoccidioides immitis RMSCC 2394Imported
Taxonomic identifieri404692 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisCoccidioides
Proteomesi
  • UP000054565 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliA0A0J6YML1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 441Peptidase_M24InterPro annotationAdd BLAST308

Family and domain databases

CDDicd01088 MetAP2, 1 hit
Gene3Di1.10.10.10, 1 hit
HAMAPiMF_03175 MetAP_2_euk, 1 hit
InterProiView protein in InterPro
IPR036005 Creatinase/aminopeptidase-like
IPR000994 Pept_M24
IPR001714 Pept_M24_MAP
IPR002468 Pept_M24A_MAP2
IPR018349 Pept_M24A_MAP2_BS
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00557 Peptidase_M24, 1 hit
PRINTSiPR00599 MAPEPTIDASE
SUPFAMiSSF46785 SSF46785, 1 hit
SSF55920 SSF55920, 2 hits
TIGRFAMsiTIGR00501 met_pdase_II, 1 hit
PROSITEiView protein in PROSITE
PS01202 MAP_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0J6YML1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKMAVQALPE INKLSVSEEG AANAAAKGQA AQGTAGNDDA ENDESDEDKE
60 70 80 90 100
DEQEVADGAA AAGGKKKKKK PKKKKKKGTA KVQSNPPRVP LSTLFPNNNY
110 120 130 140 150
PEGEIVEYKD DNAYRTTNEE KRYLDRMNND FLTDYRKSAE IHRQVRQYAQ
160 170 180 190 200
KELLKPGRSL TEIAEGIEDS VRALTGHMGL EEGDSLVAGM GFPTGLNINH
210 220 230 240 250
CAAHYSPNAG NKMVLQYGDV MKVDFGVHVN GRIVDSAFTV AFDPVYDNLL
260 270 280 290 300
NAVKDATNTG IREAGIDVRM SDIGAAIQET MESYEVEING TTYPVKAIRN
310 320 330 340 350
LNGHTIGHYL IHGGSTGKSV PIVKGGDQTK MEEGETYAIE TFGSTGKGFV
360 370 380 390 400
RDDMEVSHYA KVPDAPNVPL RLSSAKNLLN VITKNFGTLP FCRRYLDRLG
410 420 430 440 450
QEKYLLGLNN LVSSGLVDAY PPLVDVKGSY TAQFEHTILL RPNVKEVITR

GDDY
Length:454
Mass (Da):49,637
Last modified:October 14, 2015 - v1
Checksum:i07709C06179EF0C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS028097 Genomic DNA Translation: KMP08394.1

Genome annotation databases

EnsemblFungiiKMP08394; KMP08394; CIRG_08075

Similar proteinsi

Entry informationi

Entry nameiA0A0J6YML1_COCIT
AccessioniPrimary (citable) accession number: A0A0J6YML1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2015
Last sequence update: October 14, 2015
Last modified: March 28, 2018
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again