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Protein

Phospho-2-dehydro-3-deoxyheptonate aldolase

Gene

VL00_21645

Organism
Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase (Bcep18194_B0086), Phospho-2-dehydro-3-deoxyheptonate aldolase (VL00_21645), Phospho-2-dehydro-3-deoxyheptonate aldolase (VL00_14265), Phospho-2-dehydro-3-deoxyheptonate aldolase (VL00_13870), Phospho-2-dehydro-3-deoxyheptonate aldolase (VL00_02860), Phospho-2-dehydro-3-deoxyheptonate aldolase (Bcep18194_A3826), Phospho-2-dehydro-3-deoxyheptonate aldolase (WI95_29895)
  2. 3-dehydroquinate synthase (aroB), 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroQ), 3-dehydroquinate dehydratase (aroQ), 3-dehydroquinate dehydratase (aroQ), 3-dehydroquinate dehydratase (aroQ), 3-dehydroquinate dehydratase (aroQ)
  4. Shikimate dehydrogenase (NADP(+)) (aroE), Shikimate dehydrogenase (NADP(+)) (aroE), Shikimate dehydrogenase (NADP(+)) (aroE), Shikimate dehydrogenase (NADP(+)) (aroE), Shikimate dehydrogenase (NADP(+)) (aroE), Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK), Shikimate kinase (aroK), Shikimate kinase (aroK), Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA), 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC), Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotation
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00053;UER00084

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolaseUniRule annotation (EC:2.5.1.54UniRule annotation)
Gene namesi
ORF Names:VL00_21645Imported
OrganismiBurkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)Imported
Taxonomic identifieri482957 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000036081 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 339DAHP_synth_1InterPro annotationAdd BLAST296

Sequence similaritiesi

Belongs to the class-I DAHP synthase family.UniRule annotation

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR006218 DAHP1/KDSA
IPR006219 DHAP_synth_1
PANTHERiPTHR21225 PTHR21225, 1 hit
PfamiView protein in Pfam
PF00793 DAHP_synth_1, 1 hit
PIRSFiPIRSF001361 DAHP_synthase, 1 hit
TIGRFAMsiTIGR00034 aroFGH, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0J5W1T2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPHNTDDVR IRELKELTPP AHLIREFACS EAASELIYNS RQSMHRILHG
60 70 80 90 100
MDDRLIVVIG PCSIHDTKAA IEYAGRLVKE RERFKGELEI VMRVYFEKPR
110 120 130 140 150
TTVGWKGLIN DPHLDNSFKI NEGLRTAREL LLQINEMGLP AATEYLDMIS
160 170 180 190 200
PQYIADLISW GAIGARTTES QVHRELASGL SCPVGFKNGT DGNVKIAVDA
210 220 230 240 250
IKAASQPHHF LSVTKGGHSA IVSTAGNEDC HVILRGGKTP NYDAESVNAA
260 270 280 290 300
CADIGKAGLA ARLMIDASHA NSSKKHENQI PVCADIGRQI AAGDARIVGV
310 320 330 340 350
MIESHLVEGR QDLKEGCELT YGQSITDACI AWDDSVKVLE GLAESVKARR

VTRGSGN
Length:357
Mass (Da):38,862
Last modified:October 14, 2015 - v1
Checksum:iB9C197B71CF4A0E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LDWF01000047 Genomic DNA Translation: KML11362.1
RefSeqiWP_027788323.1, NZ_LDWP01000015.1

Genome annotation databases

EnsemblBacteriaiKML11362; KML11362; VL00_21645
GeneIDi29779437
PATRICifig|482957.23.peg.687

Similar proteinsi

Entry informationi

Entry nameiA0A0J5W1T2_BURL3
AccessioniPrimary (citable) accession number: A0A0J5W1T2
Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2015
Last sequence update: October 14, 2015
Last modified: September 12, 2018
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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