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UniProtKB - A0A0J4X558 (A0A0J4X558_KLEPN)

Entry version 32 (16 Oct 2019)
Sequence version 1 (14 Oct 2015)
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Protein

Probable malate:quinone oxidoreductase

Gene

mqo_2

Organism
Klebsiella pneumoniae
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADUniRule annotationSAAS annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase (mqo_1), Malate dehydrogenase (quinone) (mqo_1), Malate dehydrogenase (quinone) (mqo_2), Probable malate:quinone oxidoreductase (mqo_3), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo_1), Malate dehydrogenase (quinone) (mqo_1), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo_2), Malate dehydrogenase (quinone) (mqo_2), Probable malate:quinone oxidoreductase (mqo_1), Malate dehydrogenase (quinone) (mqo_2), Malate dehydrogenase (quinone) (DM062_14410), Probable malate:quinone oxidoreductase (mqo_2), Malate dehydrogenase (quinone) (mqo_4), Probable malate:quinone oxidoreductase (mqo_1), Malate dehydrogenase (quinone) (DM059_21065), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (mqo), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_2), Malate dehydrogenase (quinone) (DM062_23220), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_3), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo_2), Malate dehydrogenase (quinone) (mqo_2), Probable malate:quinone oxidoreductase (mqo_3), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (mqo_2), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (B4U25_23685), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo_2), Malate dehydrogenase (quinone) (mqo_2), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_1), Malate dehydrogenase (quinone) (mqo_1), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (mqo_3), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (DM062_23225), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (CSC88_37850), Malate dehydrogenase (quinone) (B4U21_19900), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (mqo_1), Malate dehydrogenase (quinone) (mqo_2), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (mqo_3), Malate dehydrogenase (quinone) (mqo_3), Probable malate:quinone oxidoreductase (mqo_1), Malate dehydrogenase (quinone) (mqo_5), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (mqo_2), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (mqo_4), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_4), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (mqo_2), Malate dehydrogenase (quinone) (mqo), Malate dehydrogenase (quinone) (B4U21_12005), Malate dehydrogenase (quinone) (mqo_3), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (CWN54_35015), Probable malate:quinone oxidoreductase (mqo_1), Malate dehydrogenase (quinone) (B4U30_22540), Malate dehydrogenase (quinone) (B4U21_19905), Malate dehydrogenase (quinone) (mqo), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo2), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (mqo_5), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported
Biological processTricarboxylic acid cycleUniRule annotationSAAS annotation
LigandFADUniRule annotationSAAS annotation, Flavoprotein

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00223;UER01008

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable malate:quinone oxidoreductaseUniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQOUniRule annotation
Malate dehydrogenase [quinone]UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mqo_2Imported
Synonyms:mqoUniRule annotation
ORF Names:NCTC9178_06434Imported, SM87_05335Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiKlebsiella pneumoniaeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri573 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Klebsiella
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000036307 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000309475 Componenti: Chromosome 1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 24DisorderedSequence analysisAdd BLAST24

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MQO family.UniRule annotationSAAS annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.50.50.60, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00212 MQO, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR006231 MQO

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06039 Mqo, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51905 SSF51905, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01320 mal_quin_oxido, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0J4X558-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKKMAVPRS QAVGPNSTRT NTRHEQETDV LLIGGGIMSA TLGTWLQELE 
        60         70         80         90        100
PDWSITMVEQ MSSVAEESSN GWNNAGTGHA ALMELNYTPQ TANGINIDKA 
       110        120        130        140        150
VDINEAFHIS RQFWAHQVTR GVLNKPKSFI NSVPHMSFVW GEDNVNFLRA 
       160        170        180        190        200
RYAALQQSEL FRGIRYSEDH QQIKAWAPLV MEGRDPQQKV AATRTEVGTD 
       210        220        230        240        250
VNYGEITRQL IAGLQKHDNF SLQLGTVVRR FKRNADKSWT VTLADADNRR 
       260        270        280        290        300
QKRVIKAKFI FIGAGGAALT LLQETGIPQA KEYAGFPVGG QFLVCENPEV 
       310        320        330        340        350
VNHHLAKVYG QAEVGAPPMS VPHIDTRIID GKRVVLFGPF ATFSTRFLKN 
       360        370        380        390        400
GSLWDLLAST NTSNILPMLN VGLDNFDLVK YLISQVMQKD KDRLAALCEY 
       410        420        430        440        450
YPEARKEDWR LWQAGQRVQI IKRDAKKGGV LRLGTEVVSD DEGTVAALLG 
       460        470        480        490        500
ASPGASTAAP IMLQLMEKVF KDKVNSPEWQ ARLKAIIPTY GIRLDGNPAE 
       510        520        530        540 
IEKALAWTSE VLELKYEPAA VADEAPQAEL KPLSGGKPMA DIAL
Length:544
Mass (Da):60,144
Last modified:October 14, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i34728D175A7CE4CC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
LFBC01000019 Genomic DNA Translation: KMI27575.1
LR588409 Genomic DNA Translation: VTO24947.1

NCBI Reference Sequences

More...RefSeqi		WP_012541003.1, NZ_UGND01000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		KMI27575; KMI27575; SM87_05335
SAU12998; SAU12998; SAMEA2273624_01684

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|573.1489.peg.2985

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LFBC01000019 Genomic DNA Translation: KMI27575.1
LR588409 Genomic DNA Translation: VTO24947.1
RefSeqiWP_012541003.1, NZ_UGND01000001.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiKMI27575; KMI27575; SM87_05335
SAU12998; SAU12998; SAMEA2273624_01684
PATRICifig|573.1489.peg.2985

Enzyme and pathway databases

UniPathwayiUPA00223;UER01008

Family and domain databases

Gene3Di3.50.50.60, 1 hit
HAMAPiMF_00212 MQO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR006231 MQO
PfamiView protein in Pfam
PF06039 Mqo, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR01320 mal_quin_oxido, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0J4X558_KLEPN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0J4X558
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2015
Last sequence update: October 14, 2015
Last modified: October 16, 2019
This is version 32 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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