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Entry version 42 (18 Sep 2019)
Sequence version 1 (14 Oct 2015)
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Protein
Submitted name:

Galactoside permease

Gene

lacY_2

Organism
Escherichia coli
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Galactoside permeaseImported
Submitted name:
H+ symporter family proteinImported
Submitted name:
Lactose-proton symportImported
Submitted name:
MFS transporterImported
Submitted name:
Sucrose transport proteinImported
Submitted name:
Sucrose transporterImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lacY_2Imported
Synonyms:lacY_1Imported, lacY_4Imported
ORF Names:AM446_09010Imported, APT94_13165Imported, BIQ87_13860Imported, BK373_06715Imported, BK375_00040Imported, BK383_24015Imported, BMT49_15390Imported, BON66_23575Imported, BON81_07445Imported, BON96_22005Imported, C3449_01145Imported, C7B08_04575Imported, CA593_15035Imported, CPA47_07690Imported, CRT46_14390Imported, CY655_15295Imported, D0X26_20220Imported, D9D31_15280Imported, D9D43_01980Imported, D9E34_17420Imported, D9E49_01610Imported, D9N32_08725Imported, DM102_06570Imported, DTM10_00450Imported, E0E06_06345Imported, EC3426_03458Imported, ELT41_08075Imported, ELV26_03700Imported, EQ820_18395Imported, EQ823_19335Imported, ERS085406_02057Imported, EVY14_15280Imported, HmCmsJML074_02214Imported, HmCmsJML204_01867Imported, MJ49_19070Imported, NCTC11112_06981Imported, NCTC9050_04810Imported, SAMEA3472090_01400Imported, SAMEA3484434_05339Imported, SAMEA3752620_00219Imported, SAMEA3753164_00785Imported, YDC107_892Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coliImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri562 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 36HelicalSequence analysisAdd BLAST25
Transmembranei48 – 67HelicalSequence analysisAdd BLAST20
Transmembranei79 – 98HelicalSequence analysisAdd BLAST20
Transmembranei110 – 128HelicalSequence analysisAdd BLAST19
Transmembranei148 – 167HelicalSequence analysisAdd BLAST20
Transmembranei173 – 190HelicalSequence analysisAdd BLAST18
Transmembranei219 – 236HelicalSequence analysisAdd BLAST18
Transmembranei258 – 281HelicalSequence analysisAdd BLAST24
Transmembranei288 – 312HelicalSequence analysisAdd BLAST25
Transmembranei318 – 336HelicalSequence analysisAdd BLAST19
Transmembranei348 – 371HelicalSequence analysisAdd BLAST24
Transmembranei377 – 398HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini223 – 415MFSInterPro annotationAdd BLAST193

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
791272at2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000576 LacY/RafB_perm_fam
IPR018457 LacY/RafB_perm_fam_CS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01306 LacY_symp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00174 LACYSMPORT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473 SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00882 2A0105, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00896 LACY_1, 1 hit
PS00897 LACY_2, 1 hit
PS50850 MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0J2GGZ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALNIPFRNA YYRFASSYSF LFFISWSLWW SLYAIWLKGH LGLTGTELGT
60 70 80 90 100
LYSVNQFTSI LFMMFYGIVQ DKLGLKKPLI WCMSFILVLT GPFMIYVYEP
110 120 130 140 150
LLQSNFSVGL ILGALFFGLG YLAGCGLLDS FTEKMARNFH FEYGTARAWG
160 170 180 190 200
SFGYAIGAFF AGIFFSISPH INFWLVSLFG AVFMMINMRF KDKDHQCIAA
210 220 230 240 250
DAGGVKKEDF IAVFKDRNFW VFVIFIVGTW SFYNIFDQQL FPVFYAGLFE
260 270 280 290 300
SHDVGTRLYG YLNSFQVVLE ALCMAIIPFF VNRVGPKNAL LIGVVIMALR
310 320 330 340 350
ILSCALFVNP WIISLVKLLH AIEVPLCVIS VFKYSVANFD KRLSSTIFLI
360 370 380 390 400
GFQIASSLGI VLLSTPTGIL FDHAGYQTVF FAISGIVCLM LLFGIFFLSK
410
KREQIVMETP VPSAI
Length:415
Mass (Da):46,924
Last modified:October 14, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD05BBD305B61AC22
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP013025 Genomic DNA Translation: ALL89559.1
CP021175 Genomic DNA Translation: ARR34318.1
CP025707 Genomic DNA Translation: AUO33120.1
CP032261 Genomic DNA Translation: AXZ85300.1
CP032879 Genomic DNA Translation: AYL09628.1
CP023820 Genomic DNA Translation: AZH34678.1
CP025573 Genomic DNA Translation: AZZ27327.1
CYBW01000009 Genomic DNA Translation: CTU54116.1
BFOO01000078 Genomic DNA Translation: GCW88717.1
BFSV01000046 Genomic DNA Translation: GDD78198.1
LNHR01000183 Genomic DNA Translation: KSX86380.1
RNLZ01000002 Genomic DNA Translation: MGE12371.1
RNRL01000036 Genomic DNA Translation: MHP36119.1
RNZZ01000047 Genomic DNA Translation: MIA39619.1
ROAL01000001 Genomic DNA Translation: MIB59139.1
MOJX01000009 Genomic DNA Translation: OJR05960.1
MOKA01000001 Genomic DNA Translation: OJR19790.1
MOKI01000055 Genomic DNA Translation: OJR51126.1
MPGQ01000001 Genomic DNA Translation: OKB79600.1
NACG01000044 Genomic DNA Translation: OWX82197.1
PYQU01000003 Genomic DNA Translation: PSY96124.1
CP020495 Genomic DNA Translation: QBR66164.1
QOGI01000001 Genomic DNA Translation: RCZ53359.1
QVOP01000024 Genomic DNA Translation: RFT86968.1
PQTE01000001 Genomic DNA Translation: RQN58501.1
SCGD01000031 Genomic DNA Translation: RWZ95150.1
SCGC01000022 Genomic DNA Translation: RXA01615.1
SEJY01000068 Genomic DNA Translation: RZA89690.1
QKMW01000004 Genomic DNA Translation: RZB27117.1
UDGK01000071 Genomic DNA Translation: SQY93010.1
UEJU01000003 Genomic DNA Translation: SRY15643.1
UGBX01000001 Genomic DNA Translation: STH89700.1
UGAW01000002 Genomic DNA Translation: STI47762.1
UINR01000001 Genomic DNA Translation: SVF56595.1
UINS01000002 Genomic DNA Translation: SVF61864.1
LS992185 Genomic DNA Translation: SYX36780.1
SJSV01000005 Genomic DNA Translation: TCD38310.1
MTWZ01000098 Genomic DNA Translation: TEZ12505.1
MTXO01000033 Genomic DNA Translation: TFA01473.1
MTYD01000061 Genomic DNA Translation: TFA65137.1
RZCP01000002 Genomic DNA Translation: TFQ10588.1
RZAX01000010 Genomic DNA Translation: TFS16644.1

NCBI Reference Sequences

More...
RefSeqi
WP_001197021.1, NZ_UWWW01000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ALL89559; ALL89559; MJ49_19070
CTU54116; CTU54116; ERS085406_02057
KLX58978; KLX58978; SK78_01510
KLX83237; KLX83237; SK83_04431
KME69305; KME69305; SM09_02516
KNY74027; KNY74027; AGA26_15985
KSX86380; KSX86380; APT94_13165
ODH25259; ODH25259; A6804_00360

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|562.6961.peg.3258

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP013025 Genomic DNA Translation: ALL89559.1
CP021175 Genomic DNA Translation: ARR34318.1
CP025707 Genomic DNA Translation: AUO33120.1
CP032261 Genomic DNA Translation: AXZ85300.1
CP032879 Genomic DNA Translation: AYL09628.1
CP023820 Genomic DNA Translation: AZH34678.1
CP025573 Genomic DNA Translation: AZZ27327.1
CYBW01000009 Genomic DNA Translation: CTU54116.1
BFOO01000078 Genomic DNA Translation: GCW88717.1
BFSV01000046 Genomic DNA Translation: GDD78198.1
LNHR01000183 Genomic DNA Translation: KSX86380.1
RNLZ01000002 Genomic DNA Translation: MGE12371.1
RNRL01000036 Genomic DNA Translation: MHP36119.1
RNZZ01000047 Genomic DNA Translation: MIA39619.1
ROAL01000001 Genomic DNA Translation: MIB59139.1
MOJX01000009 Genomic DNA Translation: OJR05960.1
MOKA01000001 Genomic DNA Translation: OJR19790.1
MOKI01000055 Genomic DNA Translation: OJR51126.1
MPGQ01000001 Genomic DNA Translation: OKB79600.1
NACG01000044 Genomic DNA Translation: OWX82197.1
PYQU01000003 Genomic DNA Translation: PSY96124.1
CP020495 Genomic DNA Translation: QBR66164.1
QOGI01000001 Genomic DNA Translation: RCZ53359.1
QVOP01000024 Genomic DNA Translation: RFT86968.1
PQTE01000001 Genomic DNA Translation: RQN58501.1
SCGD01000031 Genomic DNA Translation: RWZ95150.1
SCGC01000022 Genomic DNA Translation: RXA01615.1
SEJY01000068 Genomic DNA Translation: RZA89690.1
QKMW01000004 Genomic DNA Translation: RZB27117.1
UDGK01000071 Genomic DNA Translation: SQY93010.1
UEJU01000003 Genomic DNA Translation: SRY15643.1
UGBX01000001 Genomic DNA Translation: STH89700.1
UGAW01000002 Genomic DNA Translation: STI47762.1
UINR01000001 Genomic DNA Translation: SVF56595.1
UINS01000002 Genomic DNA Translation: SVF61864.1
LS992185 Genomic DNA Translation: SYX36780.1
SJSV01000005 Genomic DNA Translation: TCD38310.1
MTWZ01000098 Genomic DNA Translation: TEZ12505.1
MTXO01000033 Genomic DNA Translation: TFA01473.1
MTYD01000061 Genomic DNA Translation: TFA65137.1
RZCP01000002 Genomic DNA Translation: TFQ10588.1
RZAX01000010 Genomic DNA Translation: TFS16644.1
RefSeqiWP_001197021.1, NZ_UWWW01000001.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiALL89559; ALL89559; MJ49_19070
CTU54116; CTU54116; ERS085406_02057
KLX58978; KLX58978; SK78_01510
KLX83237; KLX83237; SK83_04431
KME69305; KME69305; SM09_02516
KNY74027; KNY74027; AGA26_15985
KSX86380; KSX86380; APT94_13165
ODH25259; ODH25259; A6804_00360
PATRICifig|562.6961.peg.3258

Phylogenomic databases

OrthoDBi791272at2

Family and domain databases

InterProiView protein in InterPro
IPR000576 LacY/RafB_perm_fam
IPR018457 LacY/RafB_perm_fam_CS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF01306 LacY_symp, 1 hit
PRINTSiPR00174 LACYSMPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00882 2A0105, 1 hit
PROSITEiView protein in PROSITE
PS00896 LACY_1, 1 hit
PS00897 LACY_2, 1 hit
PS50850 MFS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0J2GGZ7_ECOLX
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0J2GGZ7
Secondary accession number(s): A0A0J3YSQ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2015
Last sequence update: October 14, 2015
Last modified: September 18, 2019
This is version 42 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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