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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Dermacoccus sp. PE3
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).SAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseImported, IsomeraseUniRule annotationSAAS annotation, Transferase
Biological processPorphyrin biosynthesisUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayi
UPA00251;UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
ORF Names:AA983_11680Imported
OrganismiDermacoccus sp. PE3Imported
Taxonomic identifieri1641401 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesDermacoccaceaeDermacoccus
Proteomesi
  • UP000036330 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei273N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0I9VYL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGSTSKSAE LLAHARTVTP GGVNSPVRAF RAVGGTPRFI REAKGPWLTD
60 70 80 90 100
VDGNRYVDLI CSWGPMILGH AHPDVMTAVQ DAASRGFSFG TPSENEVALA
110 120 130 140 150
TEIVRRVEPV EQVRLVSSGT EATMSAIRLA RGATGRSKIV KFAGCYHGHV
160 170 180 190 200
DALLAAAGSG VATFALPDTA GVPKSSAGET IVLPYNDVSA LEAAFAEHGD
210 220 230 240 250
EIAAVITEAS PGNMGVVPPA PGFTKALRDI TTEHGALLVS DEVMTGFRCS
260 270 280 290 300
GAGWFGHEGQ QGESAPDLFT FGKVMGGGFP AAAFGGRADL MGMLAPDGPV
310 320 330 340 350
YQAGTLAGNP VATAAGLATL QGCTDEVYAH LDSTAHAIAD AASAELTKAG
360 370 380 390 400
VPHTVQWASS MFSIFFRDGA VTNYDDAKDQ DTEAFSRFFN AMLDQGVHLP
410 420 430 440
PSAYESWFVS ASHDDEAVAH VIDALPAAAR AAAASTDSSA TL
Length:442
Mass (Da):45,611
Last modified:October 14, 2015 - v1
Checksum:i348179903A0B957A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LDCM01000004 Genomic DNA Translation: KLO62421.1
RefSeqiWP_047312615.1, NZ_LDCM01000004.1

Genome annotation databases

EnsemblBacteriaiKLO62421; KLO62421; AA983_11680
PATRICifig|1641401.3.peg.2389

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LDCM01000004 Genomic DNA Translation: KLO62421.1
RefSeqiWP_047312615.1, NZ_LDCM01000004.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiKLO62421; KLO62421; AA983_11680
PATRICifig|1641401.3.peg.2389

Enzyme and pathway databases

UniPathwayi
UPA00251;UER00317

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0I9VYL8_9MICO
AccessioniPrimary (citable) accession number: A0A0I9VYL8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2015
Last sequence update: October 14, 2015
Last modified: November 7, 2018
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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