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Protein

Alanine racemase

Gene

ABH38_15235

Organism
Mycobacterium haemophilum
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (ABH38_15235)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei47Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei145SubstrateUniRule annotation1
Active sitei276Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei324Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
ORF Names:ABH38_15235Imported
OrganismiMycobacterium haemophilumImported
Taxonomic identifieri29311 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000036334 Componenti: Unassembled WGS sequence

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47N6-(pyridoxal phosphate)lysineUniRule annotation1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini255 – 384Ala_racemase_CInterPro annotationAdd BLAST130

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0I9V2P0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGVAVTPIS LRPGVLAEAV VDLGAIDHNV RVLREHAGSA QLMVVLKADA
60 70 80 90 100
YGHGATQVAL AALAAGAAEL GVATVDEALA LRADGISAPV LAWLHPPGID
110 120 130 140 150
FGPALAADVQ IAVSSVRQLD EVLDAVRRTG RTATVTVKAD TGLNRNGVAP
160 170 180 190 200
DQYPAMLTAL QRAVAEDAVR LRGLMSHLAY ADQPDNPSND VQGKRFAALL
210 220 230 240 250
AQARQQGVRF EVAHLSNSSA TMSRPDLAYD LVRPGIAVYG LSPVPALGDM
260 270 280 290 300
GLIPAMTVKC AVALVKSIRA GEGVSYGHAW IAQRDTNVAL LPIGYADGVF
310 320 330 340 350
RSLGGRLDVL INGKRRPGVG RICMDQFVVD LGPGPIDVAE GDEAILFGPG
360 370 380 390
ASGEPTAQDW ADLLGTIHYE VVTSPRGRIT RTYREAHTVD R
Length:391
Mass (Da):40,950
Last modified:October 14, 2015 - v1
Checksum:i511C731AF2014E3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LDPR01000013 Genomic DNA Translation: KLO35669.1
RefSeqiWP_047315547.1, NZ_LDPT01000016.1

Genome annotation databases

EnsemblBacteriaiKLO35669; KLO35669; ABH38_15235
PATRICifig|29311.18.peg.1169

Similar proteinsi

Entry informationi

Entry nameiA0A0I9V2P0_9MYCO
AccessioniPrimary (citable) accession number: A0A0I9V2P0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2015
Last sequence update: October 14, 2015
Last modified: February 28, 2018
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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