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Protein

Beta-hexosaminidase

Gene

nagZ

Organism
Vibrio cholerae
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.UniRule annotationSAAS annotation

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotationSAAS annotation

Pathwayi: peptidoglycan recycling

This protein is involved in the pathway peptidoglycan recycling, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan recycling and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei62SubstrateUniRule annotation1
Binding sitei70SubstrateUniRule annotation1
Binding sitei130SubstrateUniRule annotation1
Sitei171Important for catalytic activityUniRule annotation1
Active sitei173Proton donor/acceptorUniRule annotation1
Active sitei242NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseUniRule annotationSAAS annotationImported, Hydrolase
Biological processCell cycle, Cell divisionUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00544

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidaseUniRule annotationSAAS annotation (EC:3.2.1.52UniRule annotationSAAS annotation)
Alternative name(s):
Beta-N-acetylhexosaminidaseUniRule annotation
N-acetyl-beta-glucosaminidaseUniRule annotation
Gene namesi
Name:nagZUniRule annotationImported
ORF Names:BTY66_13595Imported, EN12_03445Imported, ERS013138_01904Imported, ERS013193_02089Imported, ERS013198_02166Imported, ERS013199_02285Imported, ERS013200_03415Imported, ERS013202_02307Imported, ERS013206_02052Imported
OrganismiVibrio choleraeImported
Taxonomic identifieri666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000043247 Componenti: Unassembled WGS sequence
  • UP000192124 Componenti: Unassembled WGS sequence
  • UP000040416 Componenti: Unassembled WGS sequence
  • UP000045578 Componenti: Unassembled WGS sequence
  • UP000042589 Componenti: Unassembled WGS sequence
  • UP000043560 Componenti: Unassembled WGS sequence
  • UP000043173 Componenti: Unassembled WGS sequence
  • UP000041770 Componenti: Unassembled WGS sequence
  • UP000036184 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 286Glyco_hydro_3InterPro annotationAdd BLAST275

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni160 – 161Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01207

Family and domain databases

Gene3Di3.20.20.300, 1 hit
HAMAPiMF_00364 NagZ, 1 hit
InterProiView protein in InterPro
IPR022956 Beta_hexosaminidase_bac
IPR019800 Glyco_hydro_3_AS
IPR001764 Glyco_hydro_3_N
IPR036962 Glyco_hydro_3_N_sf
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00933 Glyco_hydro_3, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00775 GLYCOSYL_HYDROL_F3, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0H5ZA02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLWLDVAG YELSAEDREI LQHPTVGGVI LFGRNYHDNQ QLLALNKAIR
60 70 80 90 100
QAAKRPILIG VDQEGGRVQR FREGFSRIPP AQYYARAENG VELAEQGGWL
110 120 130 140 150
MAAELIAHDV DLSFAPVLDM GFACKAIGNR AFGEDVQTVL KHSSAFLRGM
160 170 180 190 200
KAVGMATTGK HFPGHGAVIA DSHLETPYDE RETIAQDMAI FRAQIEAGVL
210 220 230 240 250
DAMMPAHVVY PHYDAQPASG SSYWLKQVLR EELGFKGIVF SDDLSMEGAA
260 270 280 290 300
VMGGPVERSH QALVAGCDMI LICNKREAAV EVLDNLPIME VPQAEALLKK
310 320 330
QQFSYSELKR LERWQQASAN MQRLIEQFSE
Length:330
Mass (Da):36,466
Last modified:October 14, 2015 - v1
Checksum:iA737BD82C149D3A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP007653 Genomic DNA Translation: AKO74305.1
CWPV01000009 Genomic DNA Translation: CSC04789.1
CWQA01000011 Genomic DNA Translation: CSC06854.1
CWQG01000009 Genomic DNA Translation: CSC19710.1
CWQD01000010 Genomic DNA Translation: CSC45579.1
CWQX01000029 Genomic DNA Translation: CSC65358.1
CWRC01000036 Genomic DNA Translation: CSC87862.1
CWQY01000033 Genomic DNA Translation: CSD17092.1
MSEO01000013 Genomic DNA Translation: OQM88749.1
RefSeqiWP_000529115.1, NZ_PYCD01000006.1

Genome annotation databases

EnsemblBacteriaiAKO74305; AKO74305; EN12_03445
CSC04789; CSC04789; ERS013193_02089
CSC06854; CSC06854; ERS013198_02166
CSC19710; CSC19710; ERS013202_02307
CSC45579; CSC45579; ERS013206_02052
CSC65358; CSC65358; ERS013199_02285
CSC87862; CSC87862; ERS013138_01904
CSD17092; CSD17092; ERS013200_03415
KEGGivcq:EN18_06865
PATRICifig|666.1969.peg.2619

Similar proteinsi

Entry informationi

Entry nameiA0A0H5ZA02_VIBCL
AccessioniPrimary (citable) accession number: A0A0H5ZA02
Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2015
Last sequence update: October 14, 2015
Last modified: July 18, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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