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Protein

Argininosuccinate synthase

Gene

argG

Organism
Bacillus smithii
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotationSAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei86CitrullineUniRule annotation1
Binding sitei116ATP; via amide nitrogenUniRule annotation1
Binding sitei118AspartateUniRule annotation1
Binding sitei122AspartateUniRule annotation1
Binding sitei122CitrullineUniRule annotation1
Binding sitei123AspartateUniRule annotation1
Binding sitei126CitrullineUniRule annotation1
Binding sitei174CitrullineUniRule annotation1
Binding sitei183CitrullineUniRule annotation1
Binding sitei259CitrullineUniRule annotation1
Binding sitei271CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 17ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotationSAAS annotation (EC:6.3.4.5UniRule annotationSAAS annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
ORF Names:BSM4216_2877Imported
OrganismiBacillus smithiiImported
Taxonomic identifieri1479 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000036353 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01940

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 1 hit
3.90.1260.10, 1 hit
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0H4P1Y2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGKKVVLAY SGGLDTSVAI QWLKDQGYDV VACCLDVGEG KDLKFIQEKA
60 70 80 90 100
LKVGAVESYV LDVKEEFANE YALLALQAHA LYEGKYPLVS ALSRPLISKK
110 120 130 140 150
LVEIAEKEGA VAVAHGCTGK GNDQVRFELS INALNPDLEV LAPVREWSWS
160 170 180 190 200
REEEIEYAKQ KGIPIPVDLD SPFSIDKNLW GRSNECGILE DPWAAPPEEA
210 220 230 240 250
YELTTSIEFT PDTPEIIEID FEKGVPVALN GKRYALSELI LELNKIAGKH
260 270 280 290 300
GVGRIDHVEN RLVGIKSREV YECPGAMTLI LAHKELEDLT LVKELAHFKP
310 320 330 340 350
VIEKKLTEVI YEGLWFSPIK DALKAFLQET QKFVTGTVRV KLFKGHAIVE
360 370 380 390 400
GRKSNYSLYN EKLATYTVED EFDHQAAVGF IKLFGLPTKV NAMVHQEKEK

VQA
Length:403
Mass (Da):44,946
Last modified:October 14, 2015 - v1
Checksum:i38F0E1763EBE3D72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP012024 Genomic DNA Translation: AKP48111.1
RefSeqiWP_048623822.1, NZ_CP012024.1

Genome annotation databases

EnsemblBacteriaiAKP48111; AKP48111; BSM4216_2877
KEGGibsm:BSM4216_2877

Similar proteinsi

Entry informationi

Entry nameiA0A0H4P1Y2_9BACI
AccessioniPrimary (citable) accession number: A0A0H4P1Y2
Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2015
Last sequence update: October 14, 2015
Last modified: September 27, 2017
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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