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Entry version 16 (12 Aug 2020)
Sequence version 1 (14 Oct 2015)
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Protein
Submitted name:

PKD1L-1

Gene

PKD1L-1

Organism
Schmidtea mediterranea (Freshwater planarian flatworm)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
PKD1L-1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PKD1L-1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchmidtea mediterranea (Freshwater planarian flatworm)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri79327 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaPlatyhelminthesRhabditophoraSeriataTricladidaContinenticolaGeoplanoideaDugesiidaeSchmidtea

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2451 – 2471HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500520412120 – 2662Sequence analysisAdd BLAST2643

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini519 – 561PKDInterPro annotationAdd BLAST43
Domaini870 – 923PKDInterPro annotationAdd BLAST54
Domaini2389 – 2436GPSInterPro annotationAdd BLAST48
Domaini2496 – 2615PLATInterPro annotationAdd BLAST120

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the polycystin family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01752, PLAT_polycystin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000203, GPS
IPR013783, Ig-like_fold
IPR022409, PKD/Chitinase_dom
IPR002859, PKD/REJ-like
IPR000601, PKD_dom
IPR035986, PKD_dom_sf
IPR001024, PLAT/LH2_dom
IPR036392, PLAT/LH2_dom_sf
IPR042060, PLAT_polycystin1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01825, GPS, 1 hit
PF01477, PLAT, 1 hit
PF02010, REJ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00303, GPS, 1 hit
SM00308, LH2, 1 hit
SM00089, PKD, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49299, SSF49299, 3 hits
SSF49723, SSF49723, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50221, GPS, 1 hit
PS50093, PKD, 2 hits
PS50095, PLAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0H3YJQ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTIFKLILS ILLIHFSRAE WCIKITLDKV VGIGTYNKDQ VSLDRTLCTD
60 70 80 90 100
ECYYSGFPFT VVWKNTYCFC ANDISAGINV TDFSTCATVD GFYVSASLAS
110 120 130 140 150
SLTVIFQMAM ATTKFIASGN LVSMSPNIYY YAPPGPPPSF KYSYHDKAGI
160 170 180 190 200
WEYSLDSNAI QRVFSISGIY QIRSQVLKPN NQAKISEVST EIMAYQSVTN
210 220 230 240 250
LNITCQPIAI VYIAVNCTVS ISNGSFITGQ IMADGLIIET LTLPDIPWER
260 270 280 290 300
VGAVPNFFNN DFITGQSVSG IYLINGQYQY NGIITSIEFN AFKTGNIDLL
310 320 330 340 350
LLKPSCGTYY CIATGSCAAT PSCSRTLACG NEYCPLSQSC SAICNNRLLN
360 370 380 390 400
KENSSSLPSV SYIINQVQLY PISNTGYQIV TLSVPWPVQA GYRLGFHFGN
410 420 430 440 450
GITDLIAVTS LRSGETPNFF YNSQTVTSGT LIPSTSFTPK YISHQFSAVS
460 470 480 490 500
VQQRNTKFKL MFNTTGIKNV TVNLQSVDNV VASASSSVIV GLNINDTSFA
510 520 530 540 550
NLGYATTNVS YMFIMNPHTG DQLLYYWDFG DNTTLNSTTR FVNHTFTVAG
560 570 580 590 600
VYNSSVYVYN TLVSKVQNYL IYVKDAVKIN FFNSSGVYNP NVFASFILSM
610 620 630 640 650
KSGTGFNCTL SGDGIANQTQ PSNNLLFGWQ WATEGSFNVR IDCYNELTRD
660 670 680 690 700
YKTLVQVIQA NITGLTFVNF GGAAFEQMQL RFSWLTGSNI TFLLLVNNIS
710 720 730 740 750
YSLTQNETAL TGISQNITIS APGVLIGVIR ATNLISDIIL VANLTFSQKI
760 770 780 790 800
SNMNLIADKY YTTNGSAFNF YVNMSTGSGV RSVIQYGDGQ NNTNINYESP
810 820 830 840 850
SVYWPGISVP YTYSNVGTYN VTVNCTNIVN SQTSSVVVYV LTGLGTYEIV
860 870 880 890 900
YNNLFFKKND LIQLSLNRTS GYPASMTNIT INWQNGDITS IPFAAFNESA
910 920 930 940 950
IYNYVYSANG VYNVTLTLQN PLSTVVKSIL LSIIDPIINF RCVNVPANTW
960 970 980 990 1000
NGNQIQLQTL VDQGQNVIYT LNPGDGGALI TKNINISTLN TQYNFNYTYN
1010 1020 1030 1040 1050
TVGNYTSNIW ACNQLGCQNC SNYVQIQYKI QSFDFQVQTN GNIEYLKTNL
1060 1070 1080 1090 1100
ITTISFTGTN FPTALMATFT LSDGSPPSTV YLSLSMMPYN FVKNLSVVGF
1110 1120 1130 1140 1150
GNILVKLENL ANSVNISATY GSFEKFSNFN VSLTWGPTRA LGFGANFNTF
1160 1170 1180 1190 1200
PLNNPVYFRP SAQAKGTVVG YTFLYAPIKN LSAIFQCNAT LVNGEFSYTF
1210 1220 1230 1240 1250
STMGDFNVSF KVYNPIDQAF IENTLTIGSS IQNTQISTRP LTLMPNYFGY
1260 1270 1280 1290 1300
ISIQWSVIST ESCICVDFAN NTKLIYGAMS GCSNCSGYLF ANRKPSNNLL
1310 1320 1330 1340 1350
EILVRFSTEG DYNIKVFIYN DYESAFANRT IPVTYAQCAP PVVSMTYTQF
1360 1370 1380 1390 1400
QNPMTPQKDI RSSQIIVSAV VLDLPCILTK NNMKLWSATL MDPIYLTPIK
1410 1420 1430 1440 1450
AVDMSIIPTS NNTQLIIPPR FLNYGLYKLT FSVTMDKNVT IYTFQSSNFT
1460 1470 1480 1490 1500
YLFIDKSPII VGLSSGGISL IVNGIDQNIC FTPLQYSQDP DLNVQDFSKW
1510 1520 1530 1540 1550
IWTWTCQKTT ESENLTNYVY PKPIGYSFTT PKTGCFGDGP GVVNFTSSPC
1560 1570 1580 1590 1600
FWGGNLEING TYQLGLVGMS SDNRTGSAKI IITVVKGIPP DITVQCLRPL
1610 1620 1630 1640 1650
MCKINNVGAF AFNEVVFNPS DALLLSATCY GNGTICGQGL WNLILLNETT
1660 1670 1680 1690 1700
QIWTPLDSSI ANLYIKGVYS MQISLLPSFF SFYNTIKRFQ ICYNSINLTP
1710 1720 1730 1740 1750
NGKSCIQFYI FPLPSGIICT LDKTTVQQTD TVCVNCTFQP NYQYRMYVNV
1760 1770 1780 1790 1800
TNECSTLGFN STGQFCSIIP YQTVNQTYIV RVTNENGGFI DVIAGIIMVT
1810 1820 1830 1840 1850
QLQLVDLTKI LTNVINGTDQ TLTVAIAKGD FKEMSQVYLK YVSVLTASNQ
1860 1870 1880 1890 1900
ITIRNLFQPL TNNSKENLGG TGYMTTSVNS STMTIESLPK DIRAKYEIDR
1910 1920 1930 1940 1950
DQKSTVINSM TAGLYTMVPG DIQSLHLISS VVNAIGESSD CVNRQSQWQL
1960 1970 1980 1990 2000
STKLASLADN FKELQKTAPR DDVLTIATNL LSANYRSDAA ANIQIDNGIL
2010 2020 2030 2040 2050
RDIKFSKDTY LDYDTNLESG GKNYLNVDDP SAAAYSLTLE TNSNFQSKIA
2060 2070 2080 2090 2100
FGVGSNSLYT IQTISKVLRD ITVLNDVPTD LLTSQMQYYS IKTQINDLSN
2110 2120 2130 2140 2150
KAFTKGRSTI ILPDICAALN SPPGSCSDPN NPIGLEIIAT PNNVRAYAQN
2160 2170 2180 2190 2200
PNKNGLPIPM NSDFVSLSLF LGRQISEKPV QPNGNNNFTI FISRDPVFAV
2210 2220 2230 2240 2250
PDFNFTEPDP QIQPPKSIPG TGTIFTGPQC FEQKLVVYQF KLIGSDQSVH
2260 2270 2280 2290 2300
FQIKSNFSTK CTQYLIVGRL GQPPVLGANP DGSVDSVNFT FWGMIPTHTK
2310 2320 2330 2340 2350
YCNLIPSSDM PDPFTFFVDN SMFKQSKIST KSSMPDYSKT LDTLYFGVRE
2360 2370 2380 2390 2400
LTPAEYDLYT RSNRPPVPYT ISAQINNTFR VRIFSTGCYF NSNNFQGGWG
2410 2420 2430 2440 2450
TAGCVVGPLT TTKVTQCICN HLTSFASGWI VAPNTIDFDY VFSNFDFTKN
2460 2470 2480 2490 2500
LTLFVTEIVV ALVFIAIFIW ARRMDIKDIE KVGVTPLPSN DANDMYLYEV
2510 2520 2530 2540 2550
TIDTSIRANA GTSSNVYFIL SGEQDETDPR HLVDNKRPIL KRGNVDRFLL
2560 2570 2580 2590 2600
AVPRSLGILQ YIRLWHDNSG KGKNASWYCN YFGVTDLQTK EKFHFLVNSW
2610 2620 2630 2640 2650
FAVEENDGQI DRLIAVASVD ELLHFEEVFS RKMKLNLSED HLWLSIMARP
2660
PESRFTRVER VA
Length:2,662
Mass (Da):294,960
Last modified:October 14, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i53CB5020CD056CE6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KT163774 mRNA Translation: AKN21724.1

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KT163774 mRNA Translation: AKN21724.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd01752, PLAT_polycystin, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR000203, GPS
IPR013783, Ig-like_fold
IPR022409, PKD/Chitinase_dom
IPR002859, PKD/REJ-like
IPR000601, PKD_dom
IPR035986, PKD_dom_sf
IPR001024, PLAT/LH2_dom
IPR036392, PLAT/LH2_dom_sf
IPR042060, PLAT_polycystin1
PfamiView protein in Pfam
PF01825, GPS, 1 hit
PF01477, PLAT, 1 hit
PF02010, REJ, 1 hit
SMARTiView protein in SMART
SM00303, GPS, 1 hit
SM00308, LH2, 1 hit
SM00089, PKD, 4 hits
SUPFAMiSSF49299, SSF49299, 3 hits
SSF49723, SSF49723, 1 hit
PROSITEiView protein in PROSITE
PS50221, GPS, 1 hit
PS50093, PKD, 2 hits
PS50095, PLAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0H3YJQ5_SCHMD
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0H3YJQ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2015
Last sequence update: October 14, 2015
Last modified: August 12, 2020
This is version 16 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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