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UniProtKB - A0A0H3W5U9 (A0A0H3W5U9_ACETH)

Entry version 34 (25 May 2022)
Sequence version 1 (14 Oct 2015)
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Protein

Aldehyde-alcohol dehydrogenase

Gene

adhE

Organism
Acetivibrio thermocellus (Hungateiclostridium thermocellum) (Clostridium thermocellum)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseUniRule annotationARBA annotation

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.1.1.71, 1530
1.2.1.10, 1530

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aldehyde-alcohol dehydrogenaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:adhEImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAcetivibrio thermocellus (Hungateiclostridium thermocellum) (Clostridium thermocellum)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1515 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Firmicutes › Clostridia › Eubacteriales › Oscillospiraceae › Acetivibrio

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A0A0H3W5U9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 406AldedhInterPro annotationAdd BLAST393
Domaini463 – 855Fe-ADHInterPro annotationAdd BLAST393

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili7 – 37Sequence analysisAdd BLAST31
Coiled coili793 – 813Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.UniRule annotation
In the N-terminal section; belongs to the aldehyde dehydrogenase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...OMAi		LMMNMPK

Family and domain databases

Conserved Domains Database

More...CDDi		cd08178, AAD_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.309.10, 1 hit
3.40.605.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR034789, AAD_C
IPR001670, ADH_Fe/GldA
IPR018211, ADH_Fe_CS
IPR039697, Alcohol_dehydrogenase_Fe
IPR016161, Ald_DH/histidinol_DH
IPR016163, Ald_DH_C
IPR016162, Ald_DH_N
IPR015590, Aldehyde_DH_dom
IPR012079, Bifunc_Ald-ADH

The PANTHER Classification System

More...PANTHERi		PTHR11496, PTHR11496, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00171, Aldedh, 1 hit
PF00465, Fe-ADH, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000111, ALDH_ADH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53720, SSF53720, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00913, ADH_IRON_1, 1 hit
PS00060, ADH_IRON_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0H3W5U9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTKIANKYEV IDNVEKLEKA LKRLREAQSV YATYTQEQVD KIFFEAAMAA 
        60         70         80         90        100
NKMRIPLAKM AVEETGMGVV EDKVIKNHYA SEYIYNAYKN TKTCGVIEED 
       110        120        130        140        150
PAFGIKKIAE PLGVIAAVIP TTNPTSTAIF KTLIALKTRN AIIISPHPRA 
       160        170        180        190        200
KNSTIEAAKI VLEAAVKAGA PEGIIGWIDV PSLELTNLVM READVILATG 
       210        220        230        240        250
GPGLVKAAYS SGKPAIGVGA GNTPAIIDDS ADIVLAVNSI IHSKTFDNGM 
       260        270        280        290        300
ICASEQSVIV LDGVYKEVKK EFEKRGCYFL NEDETEKVRK TIIINGALNA 
       310        320        330        340        350
KIVGQKAHTI ANLAGFEVPE TTKILIGEVT SVDISEEFAH EKLCPVLAMY 
       360        370        380        390        400
RAKDFDDALD KAERLVADGG FGHTSSLYID TVTQKEKLQK FSERMKTCRI 
       410        420        430        440        450
LVNTPSSQGG IGDLYNFKLA PSLTLGCGSW GGNSVSDNVG VKHLLNIKTV 
       460        470        480        490        500
AERRENMLWF RTPEKIYIKR GCLPVALDEL KNVMGKKKAF IVTDNFLYNN 
       510        520        530        540        550
GYTKPITDKL DEMGIVHKTF FDVSPDPSLA SAKAGAAEML AFQPDTIIAV 
       560        570        580        590        600
GGGSAMDAAK IMWVMYEHPE VDFMDMAMRF MDIRKRVYTF PKMGQKAYFI 
       610        620        630        640        650
AIPTSAGTGS EVTPFAVITD EKTGIKYPLA DYELLPDMAI VDADMMMNAP 
       660        670        680        690        700
KGLTAASGID ALTHALEAYV SMLATDYTDS LALRAIKMIF EYLPRAYENG 
       710        720        730        740        750
ASDPVAREKM ANAATIAGMA FANAFLGVCH SMAHKLGAFY HLPHGVANAL 
       760        770        780        790        800
MINEVIRFNS SEAPTKMGTF PQYDHPRTLE RYAEIADYIG LKGKNNEEKV 
       810        820        830        840        850
ENLIKAIDEL KEKVGIRKTI KDYDIDEKEF LDRLDEMVEQ AFDDQCTGTN 
       860        870 
PRYPLMNEIR QMYLNAYYGG AKK
Length:873
Mass (Da):96,010
Last modified:October 14, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCFF7716A8ACC9D6F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
KR632757 Genomic DNA Translation: AKK25364.1

NCBI Reference Sequences

More...RefSeqi		WP_003519039.1, NZ_SBHL01000029.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KR632757 Genomic DNA Translation: AKK25364.1
RefSeqiWP_003519039.1, NZ_SBHL01000029.1

3D structure databases

SMRiA0A0H3W5U9
ModBaseiSearch...

Phylogenomic databases

OMAiLMMNMPK

Enzyme and pathway databases

BRENDAi1.1.1.71, 1530
1.2.1.10, 1530

Family and domain databases

CDDicd08178, AAD_C, 1 hit
Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
InterProiView protein in InterPro
IPR034789, AAD_C
IPR001670, ADH_Fe/GldA
IPR018211, ADH_Fe_CS
IPR039697, Alcohol_dehydrogenase_Fe
IPR016161, Ald_DH/histidinol_DH
IPR016163, Ald_DH_C
IPR016162, Ald_DH_N
IPR015590, Aldehyde_DH_dom
IPR012079, Bifunc_Ald-ADH
PANTHERiPTHR11496, PTHR11496, 1 hit
PfamiView protein in Pfam
PF00171, Aldedh, 1 hit
PF00465, Fe-ADH, 1 hit
PIRSFiPIRSF000111, ALDH_ADH, 1 hit
SUPFAMiSSF53720, SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00913, ADH_IRON_1, 1 hit
PS00060, ADH_IRON_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0H3W5U9_ACETH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0H3W5U9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2015
Last sequence update: October 14, 2015
Last modified: May 25, 2022
This is version 34 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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