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UniProtKB - A0A0H3MZN1 (A0A0H3MZN1_CLODC)

Entry version 28 (19 Jan 2022)
Sequence version 1 (16 Sep 2015)
Previous versions | rss
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Protein
Submitted name:

Toxin B

Gene

tcdB

Organism
Clostridioides difficile (strain CD196) (Peptoclostridium difficile)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferaseARBA annotation, Hydrolase, Protease, Thiol proteaseARBA annotation, ToxinARBA annotation, Transferase
Biological processVirulenceARBA annotation
LigandLipid-bindingARBA annotation, MagnesiumARBA annotation, ManganeseARBA annotation, Metal-bindingARBA annotation, ZincARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Toxin BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tcdBImported
Ordered Locus Names:CD196_0600Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiClostridioides difficile (strain CD196) (Peptoclostridium difficile)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri645462 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Firmicutes › Clostridia › Eubacteriales › Peptostreptococcaceae › Clostridioides ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002068 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Host cell membraneARBA annotation, Host cytoplasmARBA annotation, Host endosomeARBA annotation, Host membrane, Membrane, SecretedARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Autocatalytic cleavageARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A0A0H3MZN1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini567 – 774Peptidase C80InterPro annotationAdd BLAST208
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1986 – 2005Cell wall-bindingPROSITE-ProRule annotationAdd BLAST20
Repeati2006 – 2025Cell wall-bindingPROSITE-ProRule annotationAdd BLAST20
Repeati2252 – 2271Cell wall-bindingPROSITE-ProRule annotationAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the clostridial glucosylating toxin (LCGT) family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_230825_0_0_9

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.11050, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018337, Cell_wall/Cho-bd_repeat
IPR020974, CPD_dom
IPR038383, CPD_dom_sf
IPR020972, Dermonecrotic/RTX_toxin_MLD
IPR029044, Nucleotide-diphossugar_trans
IPR024770, TcdA/TcdB_cat
IPR024772, TcdA/TcdB_N
IPR024769, TcdA/TcdB_pore_forming

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01473, Choline_bind_1, 2 hits
PF19127, Choline_bind_3, 1 hit
PF11647, MLD, 1 hit
PF11713, Peptidase_C80, 1 hit
PF12919, TcdA_TcdB, 1 hit
PF12920, TcdA_TcdB_pore, 1 hit
PF12918, TcdB_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53448, SSF53448, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51771, CGT_MARTX_CPD, 1 hit
PS51170, CW, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0H3MZN1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLVNRKQLE KMANVRFRVQ EDEYVAILDA LEEYHNMSEN TVVEKYLKLK 
        60         70         80         90        100
DINSLTDIYI DTYKKSGRNK ALKKFKEYLV TEVLELKNNN LTPVEKNLHF 
       110        120        130        140        150
VWIGGQINDT AINYINQWKD VNSDYNVNVF YDSNAFLINT LKKTIVESAT 
       160        170        180        190        200
NDTLESFREN LNDPRFDYNK FYRKRMEIIY DKQKNFINYY KTQREENPDL 
       210        220        230        240        250
IIDDIVKIYL SNEYSKDIDE LNSYIEESLN KVTENSGNDV RNFEEFKGGE 
       260        270        280        290        300
SFKLYEQELV ERWNLAAASD ILRISALKEV GGVYLDVDML PGIQPDLFES 
       310        320        330        340        350
IEKPSSVTVD FWEMVKLEAI MKYKEYIPGY TSEHFDMLDE EVQSSFESVL 
       360        370        380        390        400
ASKSDKSEIF SSLGDMEASP LEVKIAFNSK GIINQGLISV KDSYCSNLIV 
       410        420        430        440        450
KQIENRYKIL NNSLNPAISE DNDFNTTTNA FIDSIMAEAN ADNGRFMMEL 
       460        470        480        490        500
GKYLRVGFFP DVKTTINLSG PEAYAAAYQD LLMFKEGSMN IHLIEADLRN 
       510        520        530        540        550
FEISKTNISQ STEQEMASLW SFDDARAKAQ FEEYKKNYFE GSLGEDDNLD 
       560        570        580        590        600
FSQNTVVDKE YLLEKISSLA RSSERGYIHY IVQLQGDKIS YEAACNLFAK 
       610        620        630        640        650
TPYDSVLFQK NIEDSEIAYY YNPGDGEIQE IDKYKIPSII SDRPKIKLTF 
       660        670        680        690        700
IGHGKDEFNT DIFAGLDVDS LSTEIETAID LAKEDISPKS IEINLLGCNM 
       710        720        730        740        750
FSYSVNVEET YPGKLLLRVK DKVSELMPSI SQDSIIVSAN QYEVRINSEG 
       760        770        780        790        800
RRELLDHSGE WINKEESIIK DISSKEYISF NPKENKIIVK SKNLPELSTL 
       810        820        830        840        850
LQEIRNNSNS SDIELEEKVM LAECEINVIS NIDTQVVEGR IEEAKSLTSD 
       860        870        880        890        900
SINYIKNEFK LIESISDALY DLKQQNELEE SHFISFEDIL ETDEGFSIRF 
       910        920        930        940        950
IDKETGESIF VETEKAIFSE YANHITEEIS KIKGTIFDTV NGKLVKKVNL 
       960        970        980        990       1000
DATHEVNTLN AAFFIQSLIE YNSSKESLSN LSVAMKVQVY AQLFSTGLNT 
      1010       1020       1030       1040       1050
ITDAAKVVEL VSTALDETID LLPTLSEGLP VIATIIDGVS LGAAIKELSE 
      1060       1070       1080       1090       1100
TSDPLLRQEI EAKIGIMAVN LTAATTAIIT SSLGIASGFS ILLVPLAGIS 
      1110       1120       1130       1140       1150
AGIPSLVNNE LILRDKATKV VDYFSHISLA ESEGAFTSLD DKIMMPQDDL 
      1160       1170       1180       1190       1200
VISEIDFNNN SITLGKCEIW RMEGGSGHTV TDDIDHFFSA PSITYREPHL 
      1210       1220       1230       1240       1250
SIYDVLEVQK EELDLSKDLM VLPNAPNRVF AWETGWTPGL RSLENDGTKL 
      1260       1270       1280       1290       1300
LDRIRDNYEG EFYWRYFAFI ADALITTLKP RYEDTNIRIN LDSNTRSFIV 
      1310       1320       1330       1340       1350
PVITTEYIRE KLSYSFYGSG GTYALSLSQY NMNINIELNE NDTWVIDVDN 
      1360       1370       1380       1390       1400
VVRDVTIESD KIKKGDLIEN ILSKLSIEDN KIILDNHEIN FSGTLNGGNG 
      1410       1420       1430       1440       1450
FVSLTFSILE GINAVIEVDL LSKSYKVLIS GELKTLMANS NSVQQKIDYI 
      1460       1470       1480       1490       1500
GLNSELQKNI PYSFMDDKGK ENGFINCSTK EGLFVSELSD VVLISKVYMD 
      1510       1520       1530       1540       1550
NSKPLFGYCS NDLKDVKVIT KDDVIILTGY YLKDDIKISL SFTIQDENTI 
      1560       1570       1580       1590       1600
KLNGVYLDEN GVAEILKFMN KKGSTNTSDS LMSFLESMNI KSIFINSLQS 
      1610       1620       1630       1640       1650
NTKLILDTNF IISGTTSIGQ FEFICDKDNN IQPYFIKFNT LETKYTLYVG 
      1660       1670       1680       1690       1700
NRQNMIVEPN YDLDDSGDIS STVINFSQKY LYGIDSCVNK VIISPNIYTD 
      1710       1720       1730       1740       1750
EINITPIYEA NNTYPEVIVL DTNYISEKIN ININDLSIRY VWSNDGSDFI 
      1760       1770       1780       1790       1800
LMSTDEENKV SQVKIRFTNV FKGNTISDKI SFNFSDKQDV SINKVISTFT 
      1810       1820       1830       1840       1850
PSYYVEGLLN YDLGLISLYN EKFYINNFGM MVSGLVYIND SLYYFKPPIK 
      1860       1870       1880       1890       1900
NLITGFTTIG DDKYYFNPDN GGAASVGETI IDGKNYYFSQ NGVLQTGVFS 
      1910       1920       1930       1940       1950
TEDGFKYFAP ADTLDENLEG EAIDFTGKLT IDENVYYFGD NYRAAIEWQT 
      1960       1970       1980       1990       2000
LDDEVYYFST DTGRAFKGLN QIGDDKFYFN SDGIMQKGFV NINDKTFYFD 
      2010       2020       2030       2040       2050
DSGVMKSGYT EIDGKYFYFA ENGEMQIGVF NTADGFKYFA HHDEDLGNEE 
      2060       2070       2080       2090       2100
GEALSYSGIL NFNNKIYYFD DSFTAVVGWK DLEDGSKYYF DEDTAEAYIG 
      2110       2120       2130       2140       2150
ISIINDGKYY FNDSGIMQIG FVTINNEVFY FSDSGIVESG MQNIDDNYFY 
      2160       2170       2180       2190       2200
IDENGLVQIG VFDTSDGYKY FAPANTVNDN IYGQAVEYSG LVRVGEDVYY 
      2210       2220       2230       2240       2250
FGETYTIETG WIYDMENESD KYYFDPETKK AYKGINVIDD IKYYFDENGI 
      2260       2270       2280       2290       2300
MRTGLITFED NHYYFNEDGI MQYGYLNIED KTFYFSEDGI MQIGVFNTPD 
      2310       2320       2330       2340       2350
GFKYFAHQNT LDENFEGESI NYTGWLDLDE KRYYFTDEYI AATGSVIIDG 
      2360 
EEYYFDPDTA QLVISE
Length:2,366
Mass (Da):269,140
Last modified:September 16, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35BA79A879B2C199
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
FN538970 Genomic DNA Translation: CBA61153.1

NCBI Reference Sequences

More...RefSeqi		WP_009888442.1, NC_013315.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		CBA61153; CBA61153; CD196_0600

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		cdc:CD196_0600

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN538970 Genomic DNA Translation: CBA61153.1
RefSeqiWP_009888442.1, NC_013315.1

3D structure databases

SMRiA0A0H3MZN1
ModBaseiSearch...

Genome annotation databases

EnsemblBacteriaiCBA61153; CBA61153; CD196_0600
KEGGicdc:CD196_0600

Phylogenomic databases

HOGENOMiCLU_230825_0_0_9

Family and domain databases

Gene3Di3.40.50.11050, 1 hit
InterProiView protein in InterPro
IPR018337, Cell_wall/Cho-bd_repeat
IPR020974, CPD_dom
IPR038383, CPD_dom_sf
IPR020972, Dermonecrotic/RTX_toxin_MLD
IPR029044, Nucleotide-diphossugar_trans
IPR024770, TcdA/TcdB_cat
IPR024772, TcdA/TcdB_N
IPR024769, TcdA/TcdB_pore_forming
PfamiView protein in Pfam
PF01473, Choline_bind_1, 2 hits
PF19127, Choline_bind_3, 1 hit
PF11647, MLD, 1 hit
PF11713, Peptidase_C80, 1 hit
PF12919, TcdA_TcdB, 1 hit
PF12920, TcdA_TcdB_pore, 1 hit
PF12918, TcdB_N, 1 hit
SUPFAMiSSF53448, SSF53448, 1 hit
PROSITEiView protein in PROSITE
PS51771, CGT_MARTX_CPD, 1 hit
PS51170, CW, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0H3MZN1_CLODC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0H3MZN1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 16, 2015
Last sequence update: September 16, 2015
Last modified: January 19, 2022
This is version 28 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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