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UniProtKB - A0A0H3JRR3 (A0A0H3JRR3_STAAM)

Entry version 35 (10 Feb 2021)
Sequence version 1 (16 Sep 2015)
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Protein

Multifunctional fusion protein

Gene

secF

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, TranslocationUniRule annotationARBA annotation, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		SAUR158878:SAV_RS08790-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multifunctional fusion proteinUniRule annotation
Including the following 2 domains:
Protein translocase subunit SecDUniRule annotation
Protein-export membrane protein SecFUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:secFUniRule annotationImported
Synonyms:secDUniRule annotation
Ordered Locus Names:SAV1637Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri158878 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002481 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei263 – 281HelicalUniRule annotationAdd BLAST19
Transmembranei286 – 306HelicalUniRule annotationAdd BLAST21
Transmembranei312 – 336HelicalUniRule annotationAdd BLAST25
Transmembranei357 – 379HelicalUniRule annotationAdd BLAST23
Transmembranei385 – 409HelicalUniRule annotationAdd BLAST25
Transmembranei460 – 478HelicalUniRule annotationAdd BLAST19
Transmembranei574 – 591HelicalUniRule annotationAdd BLAST18
Transmembranei598 – 619HelicalUniRule annotationAdd BLAST22
Transmembranei625 – 646HelicalUniRule annotationAdd BLAST22
Transmembranei681 – 703HelicalUniRule annotationAdd BLAST23
Transmembranei709 – 731HelicalUniRule annotationAdd BLAST23

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Cell membraneUniRule annotationARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500261290723 – 759Multifunctional fusion proteinSequence analysisAdd BLAST737

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A0A0H3JRR3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.

UniRule annotation

Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.

UniRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SecD/SecF family. SecD subfamily.UniRule annotation
Belongs to the SecD/SecF family. SecF subfamily.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007894_3_0_9

Identification of Orthologs from Complete Genome Data

More...OMAi		RTVNTGM

Database for complete collections of gene phylogenies

More...PhylomeDBi		A0A0H3JRR3

Family and domain databases

HAMAP database of protein families

More...HAMAPi		MF_01463_B, SecD_B, 1 hit
MF_01464_B, SecF_B, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005791, SecD
IPR022813, SecD/SecF_arch_bac
IPR022645, SecD/SecF_bac
IPR022646, SecD/SecF_CS
IPR005665, SecF_bac

The PANTHER Classification System

More...PANTHERi		PTHR30081, PTHR30081, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07549, Sec_GG, 2 hits
PF02355, SecD_SecF, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01755, SECFTRNLCASE

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00916, 2A0604s01, 2 hits
TIGR00966, 3a0501s07, 1 hit
TIGR01129, secD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0H3JRR3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKSSRIIAF LLLVVLLFAG MAATYKSVIK NVNLGLDLQG GFEVLYQVDP 
        60         70         80         90        100
LNKGDKIDKK ALQSTAQTLE NRVNVLGVSE PKIQVEEPNR IRVQLAGVTD 
       110        120        130        140        150
QNEARKILSS QANLTIRDAE DKVKLSGSDI KQGSAKQEFK QETNQPTVTF 
       160        170        180        190        200
KVKDKNKFKK VTEEISKKRD NVMVVWLDFK KGDSYKKEAQ KKNPKFISAA 
       210        220        230        240        250
SVDQPINSDS VEISGGFKGQ EGVKKAKQIA ELLNAGSLPV DLKEIYSNSV 
       260        270        280        290        300
GAQFGQDALD KTVFASFIGV ALIYLFMLGF YRLPGLVAII ALTTYIYLTL 
       310        320        330        340        350
VAFNFISGVL TLPGLAALVL GVGMAVDANI IMYERIKDEL RIGRTIKQAF 
       360        370        380        390        400
SKANKSSFLT IFDSNLTTVI AAAVLFFFGE SSVKGFATML LLGILMIFVT 
       410        420        430        440        450
AVFLSRFLLS LLVSSNIFKN QFWLFGVKKN KRHDINEGVD VHDLKTSFEK 
       460        470        480        490        500
WNFVKLAKPL IGVSILIVVV GLVILYIFKL NLGIDFSSGT RVDFQSKQAI 
       510        520        530        540        550
TQQKVEQVVK DSGLKADQIQ INGKDNKVAT VQFKDDLTRA QDNKLSDNIK 
       560        570        580        590        600
SKFGDTPQIN TVSPIIGQEL AKNAMLALIY ASIGIIIYVS LRFEWRMGLS 
       610        620        630        640        650
SVLALLHDVF IIVAIFSLFR IEVDLTFIAA VLTIVGYSIN DTIVTFDRVR 
       660        670        680        690        700
ENLQKVKVIT TTEQIDDIVN RSIRQTMTRS INTVLTVIVV VVAILFFGAP 
       710        720        730        740        750
TIFNFTLALF IGLISGVFSS IFIAVPLWGI MKKRQLKKSP KHKLVVYKEK 

KSNDEKILV
Length:759
Mass (Da):84,254
Last modified:September 16, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E6B8BAC0D24BF47
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BA000017 Genomic DNA Translation: BAB57799.1

NCBI Reference Sequences

More...RefSeqi		WP_000749795.1, NC_002758.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		BAB57799; BAB57799; SAV1637

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sav:SAV1637

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA Translation: BAB57799.1
RefSeqiWP_000749795.1, NC_002758.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PaxDbiA0A0H3JRR3

Genome annotation databases

EnsemblBacteriaiBAB57799; BAB57799; SAV1637
KEGGisav:SAV1637

Phylogenomic databases

HOGENOMiCLU_007894_3_0_9
OMAiRTVNTGM
PhylomeDBiA0A0H3JRR3

Enzyme and pathway databases

BioCyciSAUR158878:SAV_RS08790-MONOMER

Family and domain databases

HAMAPiMF_01463_B, SecD_B, 1 hit
MF_01464_B, SecF_B, 1 hit
InterProiView protein in InterPro
IPR005791, SecD
IPR022813, SecD/SecF_arch_bac
IPR022645, SecD/SecF_bac
IPR022646, SecD/SecF_CS
IPR005665, SecF_bac
PANTHERiPTHR30081, PTHR30081, 2 hits
PfamiView protein in Pfam
PF07549, Sec_GG, 2 hits
PF02355, SecD_SecF, 2 hits
PRINTSiPR01755, SECFTRNLCASE
TIGRFAMsiTIGR00916, 2A0604s01, 2 hits
TIGR00966, 3a0501s07, 1 hit
TIGR01129, secD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0H3JRR3_STAAM
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0H3JRR3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 16, 2015
Last sequence update: September 16, 2015
Last modified: February 10, 2021
This is version 35 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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