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Protein

Lipoyl-[GcvH]:protein N-lipoyltransferase

Gene

lipL

Organism
Listeria monocytogenes serotype 1/2a (strain 10403S)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the amidotransfer (transamidation) of the lipoyl moiety from lipoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes. Takes part in a pathway for scavenging of lipoic acid.UniRule annotation

Miscellaneous

The reaction proceeds via a thioester-linked acyl-enzyme intermediate.UniRule annotation

Catalytic activityi

[Glycine cleavage system H]-N6-lipoyl-L-lysine + a [lipoyl-carrier protein] = [glycine cleavage system H] + a [lipoyl-carrier protein]-N6-lipoyl-L-lysine.UniRule annotation

Pathwayi: protein lipoylation via exogenous pathway

This protein is involved in the pathway protein lipoylation via exogenous pathway, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway protein lipoylation via exogenous pathway and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei149Acyl-thioester intermediateUniRule annotation1
Sitei161Lowers pKa of active site CysUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

UniPathwayi
UPA00537

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoyl-[GcvH]:protein N-lipoyltransferaseUniRule annotation (EC:2.3.1.200UniRule annotation)
Alternative name(s):
Lipoyl-[GcvH]:E2 amidotransferaseUniRule annotation
Gene namesi
Name:lipLUniRule annotation
Ordered Locus Names:LMRG_02703Imported
OrganismiListeria monocytogenes serotype 1/2a (strain 10403S)Imported
Taxonomic identifieri393133 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000001288 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliA0A0H3GF52
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 229BPL/LPL catalyticInterPro annotationAdd BLAST186

Sequence similaritiesi

Belongs to the octanoyltransferase LipL family.UniRule annotation

Phylogenomic databases

KOiK18821
OMAiVVRTWVH

Family and domain databases

HAMAPiMF_02119 LipL, 1 hit
InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR024897 LipL
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0H3GF52-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNIENTLLKQ DVWRFIDNTT INPAFDAIQS FATDDTLCRS VGARMAPSTV
60 70 80 90 100
RGWVHEKTVS LGIQDSKLPD IDKGIAFLQK QGYRVVVRNS GGLAVVLDSG
110 120 130 140 150
VLNLSMVLPD AERGIAIERG YETMFTLIKD MFVDCNEVIE AKEIEDSYCP
160 170 180 190 200
GSYDLSIQGK KFAGISQRRM AKGVAVQIYL AIDGDQTTRS ELIRDFYTIS
210 220 230 240 250
GKAKQTKYTF PDVNPNVMGS LSDLMKNDIS LNGTLVRLFN SLRHYAGELV
260 270
SGTLTSEELD LFPAYYERLI ARNDKVLT
Length:278
Mass (Da):30,959
Last modified:September 16, 2015 - v1
Checksum:iE09037EFF272C86E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002002 Genomic DNA Translation: AEO07542.1
RefSeqiWP_003723614.1, NC_017544.1

Genome annotation databases

EnsemblBacteriaiAEO07542; AEO07542; LMRG_02703
KEGGilmt:LMRG_02703

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002002 Genomic DNA Translation: AEO07542.1
RefSeqiWP_003723614.1, NC_017544.1

3D structure databases

ProteinModelPortaliA0A0H3GF52
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEO07542; AEO07542; LMRG_02703
KEGGilmt:LMRG_02703

Phylogenomic databases

KOiK18821
OMAiVVRTWVH

Enzyme and pathway databases

UniPathwayi
UPA00537

Family and domain databases

HAMAPiMF_02119 LipL, 1 hit
InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR024897 LipL
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0H3GF52_LISM4
AccessioniPrimary (citable) accession number: A0A0H3GF52
Entry historyiIntegrated into UniProtKB/TrEMBL: September 16, 2015
Last sequence update: September 16, 2015
Last modified: September 27, 2017
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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