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Entry version 24 (12 Aug 2020)
Sequence version 1 (16 Sep 2015)
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Protein

Cell division protein DipM

Gene

dipM

Organism
Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for efficient cell division, cell polarity and normal cell morphology (PubMed:20497504, PubMed:20497503, PubMed:20497502). Facilitates remodeling of the peptidoglycan layer and, thus, coordinated constriction of the cell envelope during the division process (PubMed:20497502, PubMed:20497504). Plays a critical role in maintaining proper cell envelope architecture during growth and division (PubMed:20497504). Required for normal envelope invagination during cell division and to establish or maintain outer membrane connections throughout the cell envelope (PubMed:20497504). May serve as a regulatory hub coordinating the activities of multiple peptidoglycan-degrading enzymes during cell constriction. Required to position SdpA and SdpB at midcell (PubMed:28833791).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell division protein DipMCurated
Alternative name(s):
Division and polarity-related metallopeptidase1 Publication
Division involved peptidase carrying LysM domains1 Publication
Division involved protein with LysM domains1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dipM3 Publications
Ordered Locus Names:CCNA_02075Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri565050 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001364 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Deletion mutant exhibits morphological defects, including cell widening and filamentation, and cell division defects (PubMed:20497504, PubMed:20497503, PubMed:20497502). Inactivation causes severe defects in outer membrane invagination, resulting in a significant delay between cytoplasmic compartmentalization and final separation of the daughter cells (PubMed:20497502). Cells lacking the gene also show outer membrane blebbing at the division site, at cell poles and along the cell body (PubMed:20497504).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500260606825 – 609Cell division protein DipMSequence analysisAdd BLAST585

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini121 – 165LysM 1PROSITE-ProRule annotationAdd BLAST45
Domaini171 – 215LysM 2PROSITE-ProRule annotationAdd BLAST45
Domaini295 – 339LysM 3PROSITE-ProRule annotationAdd BLAST45
Domaini345 – 389LysM 4PROSITE-ProRule annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni503 – 603LytM1 PublicationAdd BLAST101

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Composed of four peptidoglycan binding (LysM) domains and a C-terminal lysostaphin-like (LytM) peptidase domain. The LysM domains are the major mediators of the localization to the division site, probably via direct interaction with peptidoglycans. The LytM region is dispensable for localization, but is essential for function.3 Publications

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_029425_0_0_5

Identification of Orthologs from Complete Genome Data

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OMAi
ANGYKGP

Database of Orthologous Groups

More...
OrthoDBi
1891666at2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00118, LysM, 4 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.70.70.10, 1 hit
3.10.350.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011055, Dup_hybrid_motif
IPR018392, LysM_dom
IPR036779, LysM_dom_sf
IPR016047, Peptidase_M23

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01476, LysM, 4 hits
PF01551, Peptidase_M23, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00257, LysM, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51261, SSF51261, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51782, LYSM, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

A0A0H3C9Q9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRQLWTQAAV IALTAGTLGA PAHASGQSGQ RFTPNFPITQ PAAPPPGETI
60 70 80 90 100
QAQPGEAESL PRPTPIPVQS APPIAQAELP PPAPVSTPAP APQPVLRATP
110 120 130 140 150
PRTVVTTTVT GPVVEVAGKP QVRVVESGDA LDAIARGMGS TRAELVKLND
160 170 180 190 200
LEPPYRLKLG QKIKGPATTA KAYVVQTGDT MFAIAKRFNV TAAALAEEND
210 220 230 240 250
LKSGAAIKKG QKLLLPDGYK DKGPIKTTQV IPGTPATMVA EAEPAPATTR
260 270 280 290 300
PATPAATPSR PVRQPVSEET SEPATTSTTT LSVTGSVVTV AGPRQVHTVK
310 320 330 340 350
SGDTLTAIAR KFDMSVSELA EANKLDTEKP LKLGAKIKGP ATTQKAYSVQ
360 370 380 390 400
TGDTLGEIAK RFNVSVKALA AENNLRATAS LKKGQKIALP DGFRDKGPIR
410 420 430 440 450
TTTTTRPATP PANTYARVDS SAAAASTPSS PVPYTPSGAA PRPSAPVAAQ
460 470 480 490 500
PITPPPSSGR TIIETAAAPT EAEIIASGKG KFAWPLRGDI ISSFGVKGTG
510 520 530 540 550
QRNDGLNIRA PQGTPVLSSA DGEIAYAGNQ VPTFGNLVLV KHADGWVTAY
560 570 580 590 600
AHLSSTNVKM RQQVKQGEQL GTVGATGGVN EPQLHFEMRY APTVKDKAKP

VDPALVLPR
Length:609
Mass (Da):63,072
Last modified:September 16, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C6EFA0C426BB3B4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP001340 Genomic DNA Translation: ACL95540.1

NCBI Reference Sequences

More...
RefSeqi
WP_010919862.1, NC_011916.1
YP_002517448.1, NC_011916.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ACL95540; ACL95540; CCNA_02075

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7330381

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ccs:CCNA_02075

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|565050.3.peg.2033

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001340 Genomic DNA Translation: ACL95540.1
RefSeqiWP_010919862.1, NC_011916.1
YP_002517448.1, NC_011916.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiACL95540; ACL95540; CCNA_02075
GeneIDi7330381
KEGGiccs:CCNA_02075
PATRICifig|565050.3.peg.2033

Phylogenomic databases

HOGENOMiCLU_029425_0_0_5
OMAiANGYKGP
OrthoDBi1891666at2

Family and domain databases

CDDicd00118, LysM, 4 hits
Gene3Di2.70.70.10, 1 hit
3.10.350.10, 4 hits
InterProiView protein in InterPro
IPR011055, Dup_hybrid_motif
IPR018392, LysM_dom
IPR036779, LysM_dom_sf
IPR016047, Peptidase_M23
PfamiView protein in Pfam
PF01476, LysM, 4 hits
PF01551, Peptidase_M23, 1 hit
SMARTiView protein in SMART
SM00257, LysM, 4 hits
SUPFAMiSSF51261, SSF51261, 1 hit
PROSITEiView protein in PROSITE
PS51782, LYSM, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDIPM_CAUVN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0H3C9Q9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 12, 2018
Last sequence update: September 16, 2015
Last modified: August 12, 2020
This is version 24 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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