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Protein

Pyruvate kinase

Gene

pyk

Organism
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processGlycolysisUniRule annotation
LigandMagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00188

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Name:pykImported
Ordered Locus Names:SPD_0790Imported
OrganismiStreptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)Imported
Taxonomic identifieri373153 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001452 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi373153.SPD_0790

Structurei

3D structure databases

ProteinModelPortaliA0A0H2ZQE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 370PKInterPro annotationAdd BLAST368
Domaini386 – 497PK_CInterPro annotationAdd BLAST112

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

KOiK00873
OMAiKHEAIEQ

Family and domain databases

Gene3Di2.40.33.10, 1 hit
3.40.1380.20, 1 hit
InterProiView protein in InterPro
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR015793 Pyrv_Knase_brl
IPR015795 Pyrv_Knase_C
IPR036918 Pyrv_Knase_C_sf
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00224 PK, 1 hit
PF02887 PK_C, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 1 hit
SSF52935 SSF52935, 1 hit
TIGRFAMsiTIGR01064 pyruv_kin, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0H2ZQE0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKRVKIVAT LGPAVEIRGG KKFGEDGYWG EKLDVEASAK NIAKLIEAGA
60 70 80 90 100
NTFRFNFSHG DHQEQGERMA TVKLAEKIAG KKVGFLLDTK GPEIRTELFE
110 120 130 140 150
GEAKEYSYKT GEKIRVATKQ GIKSTREVIA LNVAGALDIY DDVEVGRQVL
160 170 180 190 200
VDDGKLGLRV VAKDDATREF EVEVENDGII AKQKGVNIPN TKIPFPALAE
210 220 230 240 250
RDNDDIRFGL EQGINFIAIS FVRTAKDVNE VRAICEETGN GHVQLFAKIE
260 270 280 290 300
NQQGIDNLDE IIEAADGIMI ARGDMGIEVP FEMVPVYQKM IIKKVNAAGK
310 320 330 340 350
VVITATNMLE TMTEKPRATR SEVSDVFNAV IDGTDATMLS GESANGKYPL
360 370 380 390 400
ESVTTMATID KNAQALLNEY GRLDSDSFER NSKTEVMASA VKDATSSMDI
410 420 430 440 450
KLVVTLTKTG HTARLISKYR PNADILALTF DELTERGLML NWGVIPMLTD
460 470 480 490 500
APSSTDDMFE IAERKAVEAG LVESGDDIVI VAGVPVGEAV RTNTMRIRTV

R
Length:501
Mass (Da):54,754
Last modified:September 16, 2015 - v1
Checksum:i9123008C3BE5F6F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000410 Genomic DNA Translation: ABJ55166.1
RefSeqiWP_001042809.1, NC_008533.2

Genome annotation databases

EnsemblBacteriaiABJ55166; ABJ55166; SPD_0790
KEGGispd:SPD_0790

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000410 Genomic DNA Translation: ABJ55166.1
RefSeqiWP_001042809.1, NC_008533.2

3D structure databases

ProteinModelPortaliA0A0H2ZQE0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi373153.SPD_0790

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ55166; ABJ55166; SPD_0790
KEGGispd:SPD_0790

Phylogenomic databases

KOiK00873
OMAiKHEAIEQ

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00188

Family and domain databases

Gene3Di2.40.33.10, 1 hit
3.40.1380.20, 1 hit
InterProiView protein in InterPro
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR015793 Pyrv_Knase_brl
IPR015795 Pyrv_Knase_C
IPR036918 Pyrv_Knase_C_sf
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00224 PK, 1 hit
PF02887 PK_C, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 1 hit
SSF52935 SSF52935, 1 hit
TIGRFAMsiTIGR01064 pyruv_kin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0H2ZQE0_STRP2
AccessioniPrimary (citable) accession number: A0A0H2ZQE0
Entry historyiIntegrated into UniProtKB/TrEMBL: September 16, 2015
Last sequence update: September 16, 2015
Last modified: November 7, 2018
This is version 19 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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