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Entry version 29 (02 Dec 2020)
Sequence version 1 (16 Sep 2015)
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Protein

Fibronectin-binding protein B

Gene

fnbB

Organism
Staphylococcus aureus (strain USA300)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Multifunctional protein which promotes bacterial attachment to fibrinogen, elastin and fibronectin (PubMed:15234962, PubMed:21569203, PubMed:27387503). Promotes also the accumulation phase and the primary attachment phase of biofilm formation (PubMed:24628034). In addition, protects against the antimicrobial activity of histones. Mechanistically, captures histones and prevents them from reaching the bacterial membrane and simultaneously binds plasminogen, thereby promoting its conversion to plasmin to destroy the bound histones (PubMed:30622139, PubMed:27387503).5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Virulence

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fibronectin-binding protein B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fnbB
Ordered Locus Names:SAUSA300_2440
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStaphylococcus aureus (strain USA300)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri367830 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001939 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell wall, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi276N → A: Loss of fibrinogen and histone binding; when associated with A-278. 2 Publications1
Mutagenesisi278F → A: Loss of fibrinogen and histone binding; when associated with A-278. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 36Sequence analysisAdd BLAST36
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500260197437 – 940Fibronectin-binding protein BSequence analysisAdd BLAST904
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000447313908 – 940Removed by sortasePROSITE-ProRule annotationAdd BLAST33

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei907Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation1

Keywords - PTMi

Peptidoglycan-anchor

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with host PLG; this interaction provides active plasmin on the surface of bacteria cells (PubMed:27387503).

Interacts with host histones (PubMed:30622139).

2 Publications

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A0H2XKG3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati681 – 718D-1By similarityAdd BLAST38
Repeati719 – 756D-2By similarityAdd BLAST38
Repeati757 – 795D-3By similarityAdd BLAST39
Repeati796 – 814D-4; truncatedBy similarityAdd BLAST19
Repeati815 – 828WR 1By similarityAdd BLAST14
Repeati829 – 842WR 2By similarityAdd BLAST14
Repeati857 – 870WR 3By similarityAdd BLAST14

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni162 – 480Fibrinogen/elastin/tropoelastin-binding1 PublicationAdd BLAST319

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi904 – 908LPXTG sorting signalPROSITE-ProRule annotation5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The fibrinogen- and elastin-binding sites have been localised to the N-terminal region.1 Publication

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009849_1_0_9

Identification of Orthologs from Complete Genome Data

More...
OMAi
WDNGVAF

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.1280, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011266, Adhesin_Fg-bd_dom_2
IPR008966, Adhesion_dom_sf
IPR011252, Fibrogen-bd_dom1
IPR004237, Fibron_repeat-bd
IPR019948, Gram-positive_anchor
IPR019931, LPXTG_anchor
IPR041171, SDR_Ig
IPR005877, YSIRK_signal_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17961, Big_8, 1 hit
PF02986, Fn_bind, 3 hits
PF00746, Gram_pos_anchor, 1 hit
PF10425, SdrG_C_C, 1 hit
PF04650, YSIRK_signal, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49401, SSF49401, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50847, GRAM_POS_ANCHORING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

A0A0H2XKG3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSNLRYGIR KHKLGAASVF LGTMIVVGMG QEKEAAASEQ NNTTVEESGS
60 70 80 90 100
SATESKASET QTTTNNVNTI DETQSYSATS TEQPSQSTQV TTEEAPKTVQ
110 120 130 140 150
APKVETSRVD LPSEKVADKE TTGTQVDIAQ PSNVSEIKPR MKRSTDVTAV
160 170 180 190 200
AEKEVVEETK ATGTDVTNKV EVEEGSEIVG HKQDTNVVNP HNAERVTLKY
210 220 230 240 250
KWKFGEGIKA GDYFDFTLSD NVETHGISTL RKVPEIKSTD GQVMATGEII
260 270 280 290 300
GERKVRYTFK EYVQEKKDLT AELSLNLFID PTTVTQKGNQ NVEVKLGETT
310 320 330 340 350
VSKIFNIQYL GGVRDNWGVT ANGRIDTLNK VDGKFSHFAY MKPNNQSLSS
360 370 380 390 400
VTVTGQVTKG NKPGVNNPTV KVYKHIGSDD LAESVYAKLD DVSKFEDVTD
410 420 430 440 450
NMSLDFDTNG GYSLNFNNLD QSKNYVIKYE GYYDSNASNL EFQTHLFGYY
460 470 480 490 500
NYYYTSNLTW KNGVAFYSNN AQGDGKDKLK EPIIEHSTPI ELEFKSEPPV
510 520 530 540 550
EKHELTGTIE ESNDSKPIDF EYHTAVEGAE GHAEGTIETE EDSIHVDFEE
560 570 580 590 600
STHENSKHHA DVVEYEEDTN PGGGQVTTES NLVEFDEDST KGIVTGAVSD
610 620 630 640 650
HTTIEDTKEY TTESNLIELV DELPEEHGQA QGPIEEITEN NHHISHSGLG
660 670 680 690 700
TENGHGNYGV IEEIEENSHV DIKSELGYEG GQNSGNQSFE EDTEEDKPKY
710 720 730 740 750
EQGGNIVDID FDSVPQIHGQ NNGNQSFEED TEKDKPKYEQ GGNIIDIDFD
760 770 780 790 800
SVPHIHGFNK HTEIIEEDTN KDKPNYQFGG HNSVDFEEDT LPQVSGHNEG
810 820 830 840 850
QQTIEEDTTP PIVPPTPPTP EVPSEPETPT PPTPEVPSEP ETPTPPTPEV
860 870 880 890 900
PTEPGKPIPP AKEEPKKPSK PVEQGKVVTP VIEINEKVKA VVPTKKAQSK
910 920 930 940
KSELPETGGE ESTNNGMLFG GLFSILGLAL LRRNKKNHKA
Length:940
Mass (Da):103,555
Last modified:September 16, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE35FBBCA907AE345
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP000255 Genomic DNA Translation: ABD22827.1

NCBI Reference Sequences

More...
RefSeqi
WP_000841422.1, NZ_CP027476.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ABD22827; ABD22827; SAUSA300_2440

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
45575650

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
saa:SAUSA300_2440

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000255 Genomic DNA Translation: ABD22827.1
RefSeqiWP_000841422.1, NZ_CP027476.1

3D structure databases

SMRiA0A0H2XKG3
ModBaseiSearch...

Genome annotation databases

EnsemblBacteriaiABD22827; ABD22827; SAUSA300_2440
GeneIDi45575650
KEGGisaa:SAUSA300_2440

Phylogenomic databases

HOGENOMiCLU_009849_1_0_9
OMAiWDNGVAF

Family and domain databases

Gene3Di2.60.40.1280, 1 hit
InterProiView protein in InterPro
IPR011266, Adhesin_Fg-bd_dom_2
IPR008966, Adhesion_dom_sf
IPR011252, Fibrogen-bd_dom1
IPR004237, Fibron_repeat-bd
IPR019948, Gram-positive_anchor
IPR019931, LPXTG_anchor
IPR041171, SDR_Ig
IPR005877, YSIRK_signal_dom
PfamiView protein in Pfam
PF17961, Big_8, 1 hit
PF02986, Fn_bind, 3 hits
PF00746, Gram_pos_anchor, 1 hit
PF10425, SdrG_C_C, 1 hit
PF04650, YSIRK_signal, 1 hit
SUPFAMiSSF49401, SSF49401, 2 hits
PROSITEiView protein in PROSITE
PS50847, GRAM_POS_ANCHORING, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFNBB_STAA3
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0H2XKG3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 5, 2019
Last sequence update: September 16, 2015
Last modified: December 2, 2020
This is version 29 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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