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Protein

Octanoyl-[GcvH]:protein N-octanoyltransferase

Gene

lipL

Organism
Bacillus cereus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes.UniRule annotation

Miscellaneous

The reaction proceeds via a thioester-linked acyl-enzyme intermediate.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

[Glycine cleavage system H]-N6-octanoyl-L-lysine + a [lipoyl-carrier protein] = glycine cleavage system H + a [lipoyl-carrier protein]-N6-octanoyl-L-lysine.UniRule annotation

Pathwayi: protein lipoylation via endogenous pathway

This protein is involved in the subpathway that synthesizes protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein].UniRule annotation This subpathway is part of the pathway protein lipoylation via endogenous pathway, which is itself part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein lipoylation via endogenous pathway and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei149Acyl-thioester intermediateUniRule annotation1
Sitei161Lowers pKa of active site CysUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Octanoyl-[GcvH]:protein N-octanoyltransferaseUniRule annotation (EC:2.3.1.204UniRule annotation)
Alternative name(s):
Octanoyl-[GcvH]:E2 amidotransferaseUniRule annotation
Gene namesi
Name:lipLUniRule annotation
ORF Names:B4077_5636Imported
OrganismiBacillus cereusImported
Taxonomic identifieri1396 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000035214 Componenti: Unassembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Belongs to the octanoyltransferase LipL family.UniRule annotation

Family and domain databases

HAMAPiMF_02119 LipL, 1 hit
InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR024897 LipL
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0G8EVV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNSRSILSQ PEWRIVDQSS LGPTFHALQS FAMDDTLCTS IGNGQSAATM
60 70 80 90 100
RSWVHHNTIV LGIQDSRLPH LEEGISFLQE NNFNVIVRNS GGLAVVLDEG
110 120 130 140 150
VLNVSLLFQE TEKGIDIDLG YDTMWHLIKE MLNDYDVTIE AKEIVGSYCP
160 170 180 190 200
GSYDLSIRNQ KFAGISQRRI RGGVAVQIYL CATGSGSERA ALVRDFYNLA
210 220 230 240 250
IQGEETRFTY PEIVPSTMAS LSELLGETIT VQDLMMRLLK TLQQFAPKLT
260 270 280
PSQLTIDEIP LYETNLQRII DRNNKALGLE K
Length:281
Mass (Da):31,361
Last modified:September 16, 2015 - v1
Checksum:i3B5BB86C8A8F5C1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LCYI01000029 Genomic DNA Translation: KLA28434.1
RefSeqiWP_046955490.1, NZ_LCYI01000029.1

Genome annotation databases

EnsemblBacteriaiKLA28434; KLA28434; B4077_5636
OAK03279; OAK03279; A6280_11025
PATRICifig|1396.428.peg.4991

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LCYI01000029 Genomic DNA Translation: KLA28434.1
RefSeqiWP_046955490.1, NZ_LCYI01000029.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiKLA28434; KLA28434; B4077_5636
OAK03279; OAK03279; A6280_11025
PATRICifig|1396.428.peg.4991

Family and domain databases

HAMAPiMF_02119 LipL, 1 hit
InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR024897 LipL
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0G8EVV4_BACCE
AccessioniPrimary (citable) accession number: A0A0G8EVV4
Entry historyiIntegrated into UniProtKB/TrEMBL: September 16, 2015
Last sequence update: September 16, 2015
Last modified: January 31, 2018
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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