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Protein

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Gene

pgsA

Organism
Brenneria goodwinii
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein catalyzes the committed step to the synthesis of the acidic phospholipids.UniRule annotation

Catalytic activityi

CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.UniRule annotation

Pathwayi: phosphatidylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (pgsA)
  2. Phosphatidylglycerophosphatase A (AWC36_13005)
This subpathway is part of the pathway phosphatidylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol, the pathway phosphatidylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotationImported
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesisUniRule annotationSAAS annotation, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00084; UER00503

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferaseUniRule annotation (EC:2.7.8.5UniRule annotation)
Alternative name(s):
Phosphatidylglycerophosphate synthaseUniRule annotation
Short name:
PGP synthaseUniRule annotation
Gene namesi
Name:pgsAUniRule annotation
ORF Names:AWC36_10000Imported, BN1221_04712cImported
OrganismiBrenneria goodwiniiImported
Taxonomic identifieri1109412 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesPectobacteriaceaeBrenneria
Proteomesi
  • UP000044377 Componenti: Unassembled WGS sequence
  • UP000217214 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicUniRule annotationAdd BLAST12
Transmembranei31 – 52HelicalSequence analysisAdd BLAST22
Topological domaini38 – 60PeriplasmicUniRule annotationAdd BLAST23
Topological domaini82 – 86CytoplasmicUniRule annotation5
Topological domaini108 – 145PeriplasmicUniRule annotationAdd BLAST38
Transmembranei120 – 143HelicalSequence analysisAdd BLAST24
Transmembranei155 – 172HelicalSequence analysisAdd BLAST18
Topological domaini169 – 181CytoplasmicUniRule annotationAdd BLAST13

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the CDP-alcohol phosphatidyltransferase class-I family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

KOiK00995

Family and domain databases

HAMAPiMF_01437 PgsA, 1 hit
InterProiView protein in InterPro
IPR000462 CDP-OH_P_trans
IPR023762 PGP_synthase_bac
IPR004570 Phosphatidylglycerol_P_synth
PfamiView protein in Pfam
PF01066 CDP-OH_P_transf, 1 hit
PIRSFiPIRSF000847 Phos_ph_gly_syn, 1 hit
TIGRFAMsiTIGR00560 pgsA, 1 hit
PROSITEiView protein in PROSITE
PS00379 CDP_ALCOHOL_P_TRANSF, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0G4K204-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFNIPTLLT LFRVALIPFF VLAFYLPFVW APLVCAVIFV FAAVTDWFDG
60 70 80 90 100
FLARRWKQTT RFGAFLDPVA DKVMVAVALV LVAEHYHSWL ITLPAATMIA
110 120 130 140 150
REIIISALRE WMAEIGKRSS VAVSWIGKVK TTAQMLALVA LLWRPERLVE
160 170 180
GAGVIALYVA AVLTFWSMFQ YLNAARHDLL EP
Length:182
Mass (Da):20,560
Last modified:September 16, 2015 - v1
Checksum:iC59A6604A5F9CB50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP014137 Genomic DNA Translation: ATA24422.1
CGIG01000001 Genomic DNA Translation: CPR21136.1
RefSeqiWP_048639349.1, NZ_CP014137.1

Genome annotation databases

EnsemblBacteriaiCPR21136; CPR21136; BN1221_04712c
KEGGibgj:AWC36_10000

Entry informationi

Entry nameiA0A0G4K204_9GAMM
AccessioniPrimary (citable) accession number: A0A0G4K204
Entry historyiIntegrated into UniProtKB/TrEMBL: September 16, 2015
Last sequence update: September 16, 2015
Last modified: March 28, 2018
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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